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Inhibitory Effect of PME88 MelonSOD on the Ultraviolet-Induced Photo-aging

PME88 멜론SOD의 자외선으로 인한 피부 광노화 억제 효과

  • Published : 2009.04.30

Abstract

PME88 (gliadin-combined) melon superoxide dismutase (SOD) is known to promote the production of the body‘s own natural antioxidants including superoxide dismutase, catalase and glutathione peroxidase. In this study, we investigated the inhibitory effects of PME88 melonSOD on the ultraviolet-induced photo-aging by the evolution of minimal erythemal dose (MED), erythema quotation and spectrocolorimetric measurements of erythema. The analysis of the evolution of the MED showed a significant increase 28 days after the daily taken of the PME88 melonSOD. The analysis of the erythema quotation showed that on D29, for the dose 1.25 MED, erythema intensity is significantly higher for placebo group than for PME88 melonSOD group. At doses 0.64 MED$_{D14}$, 0.80 MED$_{D14}$ and 1 MED$_{D14}$ the value of parameter $a^*$ (the most sensitive to the colour changes bound to the variations of blood flow. It permits to assess the evolution of erythema) is significantly higher for placebo group. No significant difference has been observed between groups (PME88 melonSOD and placebo) on the evolution of the number and consistency of feces after 4 weeks of treatment. No intolerance has been observed during the 4 weeks of treatment. These results mean that PME88 melonSOD as a dietary supplement could be useful to attenuate ultraviolet-induced skin photo-aging.

PME88 멜론(글리아딘과 결합된 식물 추출물) superoxide dismutase(SOD)의 섭취는 체내에 존재하는 superoxide dismutase, catalase 및 glutathione peroxidase를 포함한 항산화 효소의 활성 및 총량을 증가시키는 것으로 이전 연구에서 확인되었다. 본 연구에서 minimal erythema dose (MED) 값의 변화, 홍반점수의 변화, 분광비색계 측정값을 분석함으로써 자외선으로 인한 피부 광노화 억제 효과를 알아보았다. MED 값의 변화 분석에서는 PME88 멜론SOD 섭취 군에서는 시험 물질을 28일 동안 섭취한 후 MED가 유의하게 증가하였으며, 14일과 28일 사이에 그 유의성은 더욱 증가하였다. 홍반의 심한 정도(홍반점수) 분석에서 28일 동안 섭취 후 위약 군이 PME88 멜론SOD 투여군보다 1.25 MED의 자외선을 조사하였을 경우 홍반이 유의하게 나타났다. 또한 분광비색계 측정값 분석에서 0.64 MED$_{D14}$, 0.80 MED$_{D14}$, 1.0 MED$_{D14}$에서 $a^*$변수(색변화에 가장 민감한 변수, 홍반의 색조 변화를 반영)가 위약 군에서 PME88 멜론 SOD 투여군보다 유의하게 높았다. 4주간의 시험기간 동안 대변에 대한 횟수나 성향의 이상 징후 및 거부반응은 없었다. 이상의 결과들을 종합하면 PME88 멜론SOD의 섭취는 안전하게 UV로 인한 피부의 광노화를 억제하는데 유용하다는 사실을 확인하였다.

Keywords

References

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