The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
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Effect of Red Ginseng with Processed Sulfur Extracts on Serum Lipids Concentration and Metabolic Variables in Diabetic Rats

홍삼의 법제유황 처리가 당뇨쥐의 혈중지질 및 대사지표물질에 미치는 영향

  • Han, Hyun-Jung (Dept. of Preventive Oriental Medicine, College of Oriental Medicine, Wonkwang University) ;
  • Kim, Hae-Ja (Dept. Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Chong, Myong-Soo (Dept. of Preventive Oriental Medicine, College of Oriental Medicine, Wonkwang University) ;
  • Cho, Hwa-Eun (Dept. Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Choi, Yun-Hee (Dept. Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Lee, Ki-Nam (Dept. of Preventive Oriental Medicine, College of Oriental Medicine, Wonkwang University)
  • 한현정 (원광대학교 한의과대학 예방의학교실) ;
  • 김혜자 (원광대학교 한의학전문대학원 한약자원개발학과) ;
  • 정명수 (원광대학교 한의과대학 예방의학교실) ;
  • 조화은 (원광대학교 한의학전문대학원 한약자원개발학과) ;
  • 최윤희 (원광대학교 한의학전문대학원 한약자원개발학과) ;
  • 이기남 (원광대학교 한의과대학 예방의학교실)
  • Published : 2009.03.30
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Abstract

Objectives : The purpose of this study was to evaluate effects of processed sulfur with red ginseng on streptozotocin(STZ) induced diabetic rats for expansion of processed sulfur internal application. Methods : We prepared red ginseng with non processed sulfur extracts(GS), red ginseng with processed sulfur I extracts(GPS I) and red ginseng with processed sulfur II extracts(GPS II). In the present study, we examined about contents of crdue saponin, antioxidant activity, $\alpha$-glucosidase inhibitory activity, and effects of STZ induced diabetic rats. Results : Contents of crude saponin increased by processed sulfur, and GPS II was shown highest contents in crude saponin and sulfur compared with another groups. Electron donating ability of GPS II was shown highest activity compared with GS and GPS I, SOD-like activity showed same tendency as electron donating ability at 1 $mg/m\ell$ concentration. Inhibitory activity of $\alpha$-glucosidase was approximately same level in acarbose and GPS II. Blood glucose level of GPS II group was decreased 18.34% compared with DC(diabetes control) group and maintained stability range in glucose level. but GS and GPS I showed high level compared to GPS II. Serum triglycerides concentration also showed lowest level in GPS II. The activity of ALT, AST and ALP was shown high level in diabetic induced groups, and lowest level in GPS II. Creatinine was shown non-significantly difference in each groups and GPS II was shown lowest level in BUN. Conclusions : These results suggested that processed sulfur with red ginseng have improvement effects on diabetes and internal application of processed sulfur with red ginseng have no specific toxicity in liver and kidney.

Keywords

References

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