DOI QR코드

DOI QR Code

Concentration of Heavy Metals, Residual Pesticides and Sulfur Dioxide of before/after a Decoction - In Prescription of Digestive System -

전탕 전과 후의 중금속, 잔류농약 및 잔류이산화황의 농도변화 - 소화기계 약을 중심으로 -

  • Seo, Chang-Seob (Center of Herbal EBM Research, Korea Institute of Oriental Medicine) ;
  • Huang, Dae-Sun (Center of Herbal EBM Research, Korea Institute of Oriental Medicine) ;
  • Lee, Jun-Kyoung (Center of Herbal EBM Research, Korea Institute of Oriental Medicine) ;
  • Ha, Hye-Kyoung (Center of Herbal EBM Research, Korea Institute of Oriental Medicine) ;
  • Chun, Jin-Mi (Center of Herbal Resources Research, Korea Institute of Oriental Medicine) ;
  • Um, Young-Ran (Center of Herbal Quality Control, Korea Institute of Oriental Medicine) ;
  • Jang, Seol (Center of Herbal Quality Control, Korea Institute of Oriental Medicine) ;
  • Shin, Hyun-Kyoo (Center of Herbal EBM Research, Korea Institute of Oriental Medicine)
  • 서창섭 (한국한의학연구원 한약EBM연구센터) ;
  • 황대선 (한국한의학연구원 한약EBM연구센터) ;
  • 이준경 (한국한의학연구원 한약EBM연구센터) ;
  • 하혜경 (한국한의학연구원 한약EBM연구센터) ;
  • 천진미 (한국한의학연구원 한약자원연구센터) ;
  • 엄영란 (한국한의학연구원 한약품질관리센터) ;
  • 장설 (한국한의학연구원 한약품질관리센터) ;
  • 신현규 (한국한의학연구원 한약EBM연구센터)
  • Published : 2009.03.30

Abstract

Objectives : To compare the contents of hazardous substances before/after a decoction. Methods : The heavy metal contents before/after a decoction were measured by Inductively Coupled Plasma Atomic Emission Spectrometer (ICP-AES) and mercury analyzer. In order to analyze pesticides in 6 samples we used simultaneous multi-residue analysis of pesticides by GC/ECD, which was followed by GC/MSD analysis to confirm the identity of the detected pesticide in each sample. In addition, the contents of sulfur dioxide (SO2) were performed by Monier-Williams distillation method. Results : 1. The mean values of heavy metal contents (mg/kg) for the samples were as follows: Samchulkunbi-tang (before decoction - Pb; 1.592, Cd; 0.155, As; 0.055 and Hg; 0.014, after decoction - Pb; 0.036, Cd; 0.002, As; not detected and Hg; 0.001), Yijin-tang (before decoction - Pb; 0.830, Cd; 0.077, As; 0.045 and Hg; 0.015, after decoction - Pb; 0.193, Cd; 0.010, As; not detected and Hg; 0.002), Banhabaikchulcheunma-tang (before decoction - Pb; 0.976, Cd; 0.164, As; 0.167 and Hg; 0.019, after decoction - Pb; 0.031, Cd; 0.003, As; 0.006 and Hg; 0.005), Pyungwi-san (before decoction - Pb; 2.162, Cd; 0.128, As; 0.061 and Hg; 0.018, after decoction - Pb; 0.080, Cd; 0.006, As; not detected and Hg; 0.005), Leejung-tang (before decoction - Pb; 1.480, Cd; 0.294, As; 0.034 and Hg; 0.012, after decoction - Pb; 0.064, Cd; 0.007, As; 0.007 and Hg; 0.002) and Kwibi-tang (before decoction - Pb; 0.907, Cd; 0.193, As; 0.085 and Hg; 0.020, after decoction - Pb; 0.072, Cd; 0.006, As; 0.004 and Hg; 0.002). 2. Contents (mg/kg) of sulfur dioxide ($SO_2$) before a decoction in Banhabaikchulcheunma-tang, Pyungwi-san, Leejung-tang and Kwibi-tang exhibited 3.5, 3.4, 3.8 and 12.4, respectively. However, contents of sulfur dioxide after a decoction in all samples were not detected. 3. Contents (mg/kg) of residual pesticides before/after a decoction in all samples were not detected. Conclusions : These results will be used to establish a criterion of heavy metals, residual pesticides and sulfur dioxide.

Keywords

References

  1. Massaro EJ. Handbook of human toxicology. New York : Boca Raton Press. 1990 : 149-88.
  2. Rhee JS. A study on the content of heavy metal in domestic or foreign oriental medicine by means of quantitative analytical method. Seoul, Korea : MS. Thesis, Dept. of Oriental Medicine, Kyung Hee University. 1995.
  3. WHO. Lead (Environmental Health Criteria 3). WHO. 1997 : 44-54.
  4. Conor Reilly. Metal contamination of food.. London : Applied Science Publisher LTD. 1980 : 119-22.
  5. Conor Reilly. Metal contamination of food. 2nd edition. London : Elsevier Science Publishers LTD. 1991 : 95-8.
  6. Codex Alimentarius Commission, Contaminants. Joint FAO/WHO food standards program. Vol XVII, Rome. Codex Alimentarius. 1984 : 1-33.
  7. KFDA. A notice from 2008-2, Korea Food and Drug Administration. Seoul, Korea. 2008.
  8. 박성수. GC/MS를 이용한 요의 유해화학물질 및 유기인계화합물의 대사물에 관한 연구. 건국대학교 대학원 박사학위논문. 1998.
  9. Rogan WJ, Gladen BC, McKinney JD, Carreras N, Hardy P, Thullen J, Tingelstad J, Tully M. Polychlorinated biphenyls (PCBs) and dichlorodipheny dichloroethene (DDE) in human milk: effects of maternal factors and previous lactation. Am J Public Health. 1986 ; 76 : 172-7. https://doi.org/10.2105/AJPH.76.2.172
  10. Schecter A, Li L. Dioxins, dibenzofurans, dioxin-like PCBs, and DDE in US Fast Food. Chemosphere. 1995 ; 34 : 1449-57. https://doi.org/10.1016/S0045-6535(97)00441-4
  11. Stevens MF, Ebell GF, Psaila-Savona P. Organochlorine pesticides in Western Australian nur-sing mothers. Med J Aust. 1993 ; 158 : 238-41.
  12. Kutz FW, Wood PH, Bottimore DP. Organochlorine pesticides and polychlorinated biphenyls in human adipose tissue. Rev Environ Contam Tocicol. 1991 ; 120 : 1-82.
  13. KFDA. A notice from 2008-23, Korea Food and Drug Administration, Seoul, Korea. 2008.
  14. KFDA. A notice from 2008-3, Korea Food and Drug Administration, Seoul, Korea. 2008.
  15. Kim HY, Lee YJ, Hong KH, Kwon YK, Ko HS, Lee YK, Lee CW. Studies on the contents of naturally occuring of sulfite in foods. Korean J Food Sci Technol. 2000 ; 32 : 544-9.
  16. Kim HJ, Kim YK, Smith M. Sulfite analysis by ion exclusion chromatography: Application to the food and beverage industries. Food Technol. 1988 ; 11 : 113-5.
  17. Holak W, Patel B. Differential pulse polarographic determination of sulfites in foods. J Assoc Off Anal Chem. 1987 ; 70 : 572-8.
  18. Lawrence JF, Chadha RK. Determination of sulfite in foods by headspace liquid chromatography. J Assoc Off Anal Chem. 1988 ; 71 : 930-3.
  19. Perfetti GA, Joe FL, Diachenko GW. Liquid chromatographic determination of sulfite in grapes and selected grape products. J Assoc Off Anal Chem. 1989 ; 72 : 903-6.
  20. Holak W, Specchio J. Determination of sulfites in foods by simultaneous nitrogen purging and differential pulse polarography. J Assoc Off Anal Chem. 1989 ; 72 : 476-80.
  21. Sullivan JJ, Hollingworth TA, Wekell MM, Newton RT, Larose JE. Determination of sulfite in food by flow injection analysis. J Assoc Off Anal Chem. 1986 ; 69 : 542-6.
  22. Seo CS, Huang DS, Lee JK, Ha HK, Chun JM, Um YR, Jang S, Shin HK. Concentration of heavy metals, residual pesticides and sulfur dioxide of before/after a decoction. Kor J Herbology. 2008 ; 23 : 51-8.
  23. Korean Code of Food. Korea Food & Drug Administration. 2005.