The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
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Effects of Herbal Composition and Fermented Cervi Pantotrichum Cornu on Longitudinal Bone Growth in Adolescent Male Rats

한약혼합제제(韓藥混合製劑)와 녹용발효추출물(鹿茸醱酵抽出物)의 성장기(成長期) 흰쥐 장골(長骨) 길이 성장(成長)에 대한 효과

  • Lee, Se-Na (Department of Herbolog1y College of Oriental Medicine, Semyung University) ;
  • Son, Jae-Bong (Department of Herbolog1y College of Oriental Medicine, Semyung University) ;
  • Sohn, Jong-Hee (Amorepacific Corporation R&D Center) ;
  • Kim, Wan-Ki (Amorepacific Corporation R&D Center) ;
  • Lee, Sang-Jun (Amorepacific Corporation R&D Center) ;
  • Lee, Pyeong-Jae (Department of Natural Medicine Resources, Semyung University) ;
  • Leem, Kang-Hyun (Department of Herbolog1y College of Oriental Medicine, Semyung University)
  • 이세나 (세명대학교 한의과대학 본초학교실) ;
  • 손재봉 (세명대학교 한의과대학 본초학교실) ;
  • 손종희 ((주)아모레퍼시픽 기술연구원) ;
  • 김완기 ((주)아모레퍼시픽 기술연구원) ;
  • 이상준 ((주)아모레퍼시픽 기술연구원) ;
  • 이평재 (세명대학교 자연약재과학과) ;
  • 임강현 (세명대학교 한의과대학 본초학교실)
  • Published : 2009.03.30
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Abstract

Objectives：This study was designed to investigate the effects of herbal composition and fermented Cervi Pantotrichum Cornu on the growth of longitudinal bone in the adolescent male rats. Methods： Longitudinal bone growth was measured by fluorescence microscopy. To examine the effects on the growth plate metabolism, the total height of growth plate and the induction of local insulin-like growth factor-1 (IGF-1) and bone morphogenetic protein-2 (BMP-2) were measured. Results： The herbal composition treatment enhanced longitudinal bone growth and total heght of growth plate and promoted the induction of local IGF-1 and BMP-2 of growth plate. Conclusions： This study showed that the herbal composition have the effect of bone growth in adolescent rats and might be used for the growth delayed adolescent and inherent growth failure patient.

Keywords

References

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