The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
권호 표지
DOI QR코드

DOI QR Code

Effects of Citri Reticulatae Viride Pericarpium on the Changes of Tyrosine Hydroxylase and ACTH in the Forced Swimming Test

청피가 FST에서 TH와 ACTH변화에 미치는 영향

  • Park, Soo-Hyun (Dept. of Formulae Pharmacology, College of Oriental Medicine, Kyungwon University) ;
  • Lee, Tae-Hee (Dept. of Formulae Pharmacology, College of Oriental Medicine, Kyungwon University)
  • 박수현 (경원대학교 한의과대학 방제학교실) ;
  • 이태희 (경원대학교 한의과대학 방제학교실)
  • Published : 2009.03.30
Download PDF
⟨ Previous Next ⟩

Abstract

Objectives : The investigation of the antidepressant effects of Citri Reticulatae Viride Pericarpium (CR) Methods : we performed the forced swimming test. Also the expression of Tyrosine Hydroxylase (TH) was measured with immunohistochemical method at the Ventral Tegmental area (VTA), Locus coeruleus (LC). The Adrenocorticotropic Hormone (ACTH) level was measured in plasma. Results: 1. The duration of immobility in the forced swimming test was significantly decreased in the CR 100 mg/kg, CR 400 mg/kg groups, comparing with the control group (p < 0.05, p < 0.001). 2. TH expressions in the VTA, LC were significantly reduced in the CR 100mg/kg and CR 400mg/kg treated group, comparing with the control group (p < 0.05, p < 0.001). 3. ACTH expression in plama was significantly reduced in the CR 100 mg/kg treated group, comparing with the control group (p < 0.05). Conclusions : According to the above results, it can be considered that Citri Reticulatae Viride Pericarpium has antidepressant effect through the reduction of TH expression at VTA, LC and ACTH level in plasma.

Keywords

References

  1. 대한신경정신의학회. 신경정신과학. 서울 : 하나의학사. 1998 : 361-86.
  2. 김정엽. 우울의 발생요인 및 면역기능과의 관계에 대한 연구. 경기전문대학 논문집 1994 ; 22 : 33-42.
  3. 민성길. 최신정신의학. 서울 : 일조각. 1998 ; 199-219.
  4. Halas RE, Yudofsky SC, Talbott JA. Psychopharmacology and elctroconvulsive therapy, in Textbook of psychiatry. 3rd ed. The American psychiatric press. 1999 : 479-565.
  5. 황의완, 김지혁 편저. 동의정신의학. 현대의학서적사. 1987 : 608-11.
  6. 조홍건 외 편저. 실용한방정신의학. 유진문화사. 2002 : 184-90.
  7. Car H, Wisniewska RJ, Wisniewski K. 2R, 4R-APDC influence on hypoxia-induced impairment of learning and memory processes in passive avoidance test. Pol J Pharmacol. 2004 ; 56(5) : 527-37.
  8. Hickey RW, Akino M, Strausbaugh S, De Courtmn, Myers GM. Use of the Morris water maze and acoustic stratle chamber to evaluate neurologic injury after asphyximal arrest in rats. Pediatry Res. 1996 ; 39(1) : 77-84.
  9. Dawson GR, Tricklebank MD. Use of the elevated plus maze in the search for novel anxiolytic agents. Trends Pharmacol. 1995 ; 16(2) : 33-6. https://doi.org/10.1016/S0165-6147(00)88973-7
  10. Bolhuis JJ, Bijlsma S, Ansmink P. Exponential decay of spatial memory of rats in a radial maze. Behavioural and Neural biology. 1986 ; 46 : 115-22. https://doi.org/10.1016/S0163-1047(86)90584-4
  11. Zacharko RM, Anisman H. Stressor-induced anhedonia and the mesocorticolimbic system. Neurosci Biobehav Rev. 1991 ; 15 : 391-405. https://doi.org/10.1016/S0149-7634(05)80032-6
  12. David DJ, Bourin M, Hascoet M, Colombel MC, Baker GB, Jolliet P. Comparison of antidepressant activity in 4- and 40-week-old male mice in the forced swimming test : involvement of 5-HT1A and 5-HT1b receptors in old mice. Psychopharmacology (Berl). 2001 ; 153(4) : 443-9. https://doi.org/10.1007/s002130000588
  13. 강영건, 이태희. 구속 스트레스로 유발된 기억 손상에 대한 麥門冬의 신경보호 효능. 대한본초학회지. 2006 ; 21(2) : 63-75.
  14. 고동균, 이태희. 지골피가 스트레스로 인한 기억저하와 우울행동에 미치는 영향. 대한본초학회지. 2007 ; 22 : 137-46.
  15. 신화석, 권영모, 박선동. 四逆散의 抗憂鬱效果 및 腦內 monoamine에 미치는 영향. 대한본초학회지. 2004 ; 19(2) : 71-82.
  16. 전국한의과대학 본초학교수 공편저. 본초학. 서울 : 영림사. 1998 : 349-50.
  17. 이금수, 정현우, 이원석. 靑皮가 腦血流力學에 미치는 실험적 연구. 동의생리병리학회지. 2002 ; 16(1) : 104-10.
  18. 정현우, 오찬호, 은재순. 靑皮가 마우스의 免疫細胞에 미치는 影響. 대한동의병리학회지. 1998 ; 12(2) : 55-62.
  19. 권용욱. 靑皮가 FST에서 나타나는 우울행동에 미치는 영향. 경원대학교 대학원. 2008.
  20. G Garcia, P Tagliaferro, A Ferri, AM Evangelista de Duffard, R Duffard, A Brusco. Study of Tyrosine Hydroxylase Immunoreactive Neurons in Neonate Rats Lactationally Exposed to 2, 4-Dichlorophenoxyacetic Acid. Neurotoxicology. 2004 ; 25 : 951-7. https://doi.org/10.1016/j.neuro.2004.05.004
  21. Silja Bellingrath, Brigitte M Kudielka. Effort-reward-imbalance and overcommitment are associated with hypothalamus-pituitary-adrenal (HPA) axis responses to acute psychlocial stress in healthy working schoolteachers. Psychoneuroendocrinology. 2008 ; 33 : 1335-43. https://doi.org/10.1016/j.psyneuen.2008.07.008
  22. 김상효. 동의신경정신과학. 서울 : 행림출판사. 1980 : 72-5, 258-64, 277-84.
  23. 왕현명. 중의내과변증학. 북경 : 인민위생출판사. 1984 : 460-7, 470-85.
  24. 여광영. 중위뇌병증치. 북경 : 과학기술문헌출판사. 1991 : 72-81.
  25. 朱震亨. 丹溪心法附餘. 서울 : 대성문화사. 1982 : 515-27.
  26. 張介賓. 景岳全書. 서울 : 정담. 1999 : 385-6, 692, 1150.
  27. 葉天士. 臨證指南醫案. 서울 : 정담. 1998 : 463-73.
  28. 趙尙華. 張子琳醫療經驗選輯. 太原 : 山西人民出版社. 1986 : 88-91.
  29. 서원희, 이상용. 鬱症과 憂鬱症의 比較考察. 대전대학교 한의학연구소 논문집. 1997 ; 6(1) : 505-14.
  30. Porsolt RD, Bertin A, Jalfre M. Behavioral despair in rats : A new model sensitive to antidepressant treatments. European Journal of Pharmacology. 1978 ; 47(4) : 379-91. https://doi.org/10.1016/0014-2999(78)90118-8
  31. 신경호. 우울증의 실험모델과 항우울제의 선별. 대한정신약물학회지. 2000 ; 11(4) : 291-303.
  32. 권영재. 강제 수영에 의한 행동절망에 있어서 중추성 Monoamines계의 역할에 관한 연구. 부산대학교 대학원. 1990.
  33. Bowden C. Reduced dopamine turnover in the basal ganglia of depression suicides. Brain Res. 1997 ; 769(1) : 135-40. https://doi.org/10.1016/S0006-8993(97)00692-6
  34. Burn DJ. Depression in parkinson's disease. European Journal of Neurology. 2002 ; 9(3) : 44-54. https://doi.org/10.1046/j.1468-1331.9.s3.6.x
  35. Beitner-Johnson D, Guitart X, Nesteler EJ. Neurofilament proteins and the mesolimbic dopamine system : common regulation by chronic morphine and chronic cocaine in the rat ventral tegmental area. J Neurosci. 1992 ; 12(6) : 2165-76.
  36. Crossman AR, Neary D. Neuroanatomy. New York : Churchill Livingstone. 1996 : 65-9, 121-2.
  37. Daniel SM, Amer Karmal, Marten PS, Geert MJ. Modulation of cellular activity and synaptic transmission in the ventral tegmental area. European Journal of Pharmacology. 2003 ; 480 : 97-115. https://doi.org/10.1016/j.ejphar.2003.08.097
  38. Ortiz J, Fitzgerald LW, Lane S, Terwilliger R, Nestler EJ. Biochemical adaptations in the mesolimbic dopamine system in response to repeated stress. Neuropsychopharmacology. 1996 ; 14(6)：443-52. https://doi.org/10.1016/0893-133X(95)00152-4
  39. Nestler EJ, Carelzon Jr. The mesolimbic dopamine reward circuit in depression. Biol Psychiatry. 2006 ; 59(12) : 1151-9. https://doi.org/10.1016/j.biopsych.2005.09.018
  40. 배춘상, 백서용, 조희중, 차중익, 천병훈. 신경해부학. 서울 ; 고문사. 1998 : 102-208.
  41. Meng-Yang Zhu, Violetta Klimek, Ginny E Dilley, John W Haycock, Craig Stockmeier, James C Overholser, Herbert Y Meltzer, Gregory A Ordway. Elevated levels of tyrosine hydroxylase in the locus coeruleus in major depression Biological Psychiatry. November 1999 ; Vol 46, Issue 9, 1 : 1275-86. https://doi.org/10.1016/S0006-3223(99)00135-3
  42. 조충훈. 淸火補心湯이 憂鬱症 模型動物의 絶望行動, 不安 및 腦의 TH와 c-Fos 發顯에 미치는 效果. 경희대학교 대학원. 2003.
  43. 김종찬. 憂鬱症 모델 흰쥐의 水中迷路學習과 VTA의 TH 水準에 對한 古庵心賢丸去朱砂防의 效果. 경희대학교 대학원. 2002.