The Journal of Korean Medicine (대한한의학회지)

The Society of Korean Medicine (대한한의학회)
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A Cross-Sectional Study on Lifestyle and Plasma Homocysteine Concentrations in Patients with Acute Cerebral Infarction

급성기 뇌경색 환자의 생활습관과 혈장 homocysteine 농도에 관한 단면적 연구

  • Min, In-Kyu (Department of Cardiocascular & Neurologic Disease(Stroke center), College of Oriental medicine, Kyunghee University) ;
  • Leem, Jung-Tae (Department of Cardiocascular & Neurologic Disease(Stroke center), College of Oriental medicine, Kyunghee University) ;
  • Kim, Mi-Young (Department of Cardiocascular & Neurologic Disease(Stroke center), College of Oriental medicine, Kyunghee University) ;
  • Choi, Won-Woo (Department of Cardiocascular & Neurologic Disease(Stroke center), College of Oriental medicine, Kyunghee University) ;
  • Jung, Woo-Sang (Department of Cardiocascular & Neurologic Disease(Stroke center), College of Oriental medicine, Kyunghee University) ;
  • Moon, Sang-Kwan (Department of Cardiocascular & Neurologic Disease(Stroke center), College of Oriental medicine, Kyunghee University) ;
  • Cho, Ki-Ho (Department of Cardiocascular & Neurologic Disease(Stroke center), College of Oriental medicine, Kyunghee University) ;
  • Kim, Young-Suk (Department of Cardiocascular & Neurologic Disease(Stroke center), College of Oriental medicine, Kyunghee University)
  • 민인규 (경희대학교 한의과대학 2내과학교실) ;
  • 임정태 (경희대학교 한의과대학 2내과학교실) ;
  • 김미영 (경희대학교 한의과대학 2내과학교실) ;
  • 최원우 (경희대학교 한의과대학 2내과학교실) ;
  • 정우상 (경희대학교 한의과대학 2내과학교실) ;
  • 문상관 (경희대학교 한의과대학 2내과학교실) ;
  • 조기호 (경희대학교 한의과대학 2내과학교실) ;
  • 김영석 (경희대학교 한의과대학 2내과학교실)
  • Published : 2009.03.31
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Abstract

Objectives: We tried to clarify the relationship between lifestyle and plasma homocysteine concentration. We analyzed the data of patients with acute ischemic stroke from the Hanbang stroke registry supported by the Ministry of Science and Technology of Korea. Methods: 458 subjects were recruited from the patients admitted to the Internal Medical Department of Kyunghee University oriental medical center, Dongguk University Ilsan oriental medical center, Kyungwon University Songpa oriental medical center and Kyungwon University Incheon oriental medical center from April 2007 to August 2008. We divided the subjects into four groups by quartiles of plasma homocysteine concentrations and compared the first and last quartile groups. Results: 1. In univariate analysis, the high homocysteine concentration group showed higher rate of older age, male gender, smoking, drinking and lower values in vitamin B12, folic acid, creatinine than the control group with statistical significance. 2. In multivariate analysis, older age, male gender smoking and folic acid showed a close relationship with statistical significance (each OR=3.620, OR=4.218, OR=3.558, OR=0.789). Conclusions: According to the analysis, the relationship between high homocysteine concentration and smoking in patients with acute ischemic stroke were clarified. We hope to standardize and establish criteria on homocysteine in Korea by large epidemiological survey. These study results could be utilized in the future as a basis material.

Keywords

References

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