Korean Journal of Medicinal Crop Science (한국약용작물학회지)

The Korean Society of Medicinal Crop Science (한국약용작물학회)
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Comparative Effect on Anti-Inflammatory Activity of the Phellinus linteus and Phellinus linteus Grown in Germinated Brown Rice Extracts in Murine Macrophage RAW 264.7 Cells

상황버섯과 발아현미상황버섯 열수추출물의 Murin Macrophage RAW 264.7 세포에서 항염증 반응 비교

  • Jeoung, Young-Jun (Dept. of Life Science, College of Biomedical & Health Science, Konkuk University) ;
  • Choi, Se-Young (Dept. of Life Science, College of Biomedical & Health Science, Konkuk University) ;
  • An, Chi-Sun (Dept. of Life Science, College of Biomedical & Health Science, Konkuk University) ;
  • Jeon, Yun-Hee (Dept. of Life Science, College of Biomedical & Health Science, Konkuk University) ;
  • Park, Dong-Ki (Dept. of Bioscience and Biotechnology, Konkuk University) ;
  • Lim, Beoung-Ou (Dept. of Life Science, College of Biomedical & Health Science, Konkuk University)
  • 정용준 (건국대학교 생명과학부 응용생화학과) ;
  • 최세영 (건국대학교 생명과학부 응용생화학과) ;
  • 안치선 (건국대학교 생명과학부 응용생화학과) ;
  • 전윤희 (건국대학교 생명과학부 응용생화학과) ;
  • 박동기 (건국대학교 특성화학부) ;
  • 임병우 (건국대학교 생명과학부 응용생화학과)
  • Published : 2009.04.30
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Abstract

The present study describes the preliminary evaluation of the anti-inflammatory activities of Phellinus linteus (PL) and Phellinus linteus Grow in Germinated Brown Rice (BRPL). In order to effectively screen for anti-inflammatory agents, we first examined the extracts' inhibitory effects on the expression of pro-inflammatory cytokines activated with lipopolysaccharide. Moreover, we examined the inhibitory effects of the PL and BRPL extracts on pro-inflammatory factors such as NO, iNOS, $TNF-{\alpha}$ and $IFN-{\gamma}$ in murine macrophage RAW 264.7 cells. NO production and iNOS expression was significantly augmented in LPS treated cell, the production of NO and iNOS was greater in the BRPL than in the PL group. In addition, protein and mRNA levels of $TNF-{\alpha}$ and $IFN-{\gamma}$ in BRPL showed relatively more potent pro-inflammatory-activity inhibition compared to that of PL. These results suggest that BRPL may have significant effects on inflammatory factors, and may be a potential anti-inflammatory therapeutic materials.

Keywords

References

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