Korean Journal of Medicinal Crop Science (한국약용작물학회지)

The Korean Society of Medicinal Crop Science (한국약용작물학회)
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Enhancement of Anticancer Activities of Ephedra sinica, Angelica gigas by Ultra High Pressure Extraction

초고압 추출 처리에 의한 마황과 당귀의 항암 활성 증진

  • Jeong, Hyang-Suk (College of Bioscience & Biotechnology, Kangwon National Univ.) ;
  • Han, Jae-Gun (College of Bioscience & Biotechnology, Kangwon National Univ.) ;
  • Ha, Ji-Hye (College of Bioscience & Biotechnology, Kangwon National Univ.) ;
  • Kim, Young (College of Bioscience & Biotechnology, Kangwon National Univ.) ;
  • Oh, Sung-Ho (College of Bioscience & Biotechnology, Kangwon National Univ.) ;
  • Kim, Seoung-Seop (College of Bioscience & Biotechnology, Kangwon National Univ.) ;
  • Jeong, Myoung-Hoon (College of Bioscience & Biotechnology, Kangwon National Univ.) ;
  • Choi, Geun-Pyo (Department of Food Processing & Bakery, Gangwon Provincial Univ) ;
  • Park, Uk-Yeon (Department of Food Processing & Bakery, Gangwon Provincial Univ) ;
  • Lee, Hyeon-Yong (College of Bioscience & Biotechnology, Kangwon National Univ.)
  • 정향숙 (강원대학교 BT특성화학부대학) ;
  • 한재건 (강원대학교 BT특성화학부대학) ;
  • 하지혜 (강원대학교 BT특성화학부대학) ;
  • 김영 (강원대학교 BT특성화학부대학) ;
  • 오성호 (강원대학교 BT특성화학부대학) ;
  • 김승섭 (강원대학교 BT특성화학부대학) ;
  • 정명훈 (강원대학교 BT특성화학부대학) ;
  • 최근표 (강원도립대학 식품가공제과제빵과) ;
  • 박욱연 (강원도립대학 식품가공제과제빵과) ;
  • 이현용 (강원대학교 BT특성화학부대학)
  • Published : 2009.04.30
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Abstract

This study was performed to enhance anticancer activities of E. sinica, and A. gigas by ultra high pressure extraction process. The cytotoxicity of E. sinica and A. gigas on human kidney cell (HEK293) was as low as 24.94% and 25.3% in adding 1.0 $mg/m{\ell}$ of the sample extracted at 500 Mpa for 15 minute. Generally, the inhibition of cancer cell growth on A549 and MCF-7 was increased over 20% in the ultra high pressure samples, compared to the conventional extraction process. Under the extracts from ultra high pressure process showed not only the strongest anticancer activities, but also had better stability than normal extracts. It was also found that the extracts of A. gigas reduced the hypertrophy of the internal organs, such as adrenal and spleen caused stresses in several mouse models.

Keywords

References

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