Pediatric Gastroenterology, Hepatology & Nutrition

The Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition (대한소아소화기영양학회)
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Changes in the Prevalence of Biopsy-proven Helicobacter pylori Infection in Korean Children with Functional Recurrent Abdominal Pain Over the Last 18 Years

최근 18년간 한국 소아 Helicobacter pylori 유병률의 변화: 기능성 반복성 복통 소아에서 연도별 내시경 진단 양성률의 감소에 관한 연구

  • Lee, So-Yeon (Department of Pediatrics, Seoul National University College of Medicine) ;
  • Ko, Jae-Sung (Department of Pediatrics, Seoul National University College of Medicine) ;
  • Seo, Jeong-Kee (Department of Pediatrics, Seoul National University College of Medicine)
  • 이소연 (서울대학교 의과대학 소아청소년과학교실) ;
  • 고재성 (서울대학교 의과대학 소아청소년과학교실) ;
  • 서정기 (서울대학교 의과대학 소아청소년과학교실)
  • Received : 2009.08.03
  • Accepted : 2009.08.31
  • Published : 2009.09.30
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Abstract

Purpose: The aim of this study was to evaluate observed changes in the prevalence of biopsy-proven Helicobacter pylori infection in Korean children with functional recurrent abdominal pain during the past 18 years. Methods: Between July 1991 and December 2008, 1,194 children with functional recurrent abdominal pain (499 males and 695 females) 9.2${\pm}$3.1 years of age were included. Upper gastrointestinal endoscopies were performed in all patients. H. pylori infection was assessed by the CLO test. Changes in the prevalence of the endoscopic diagnosis of H. pylori infection during 18 years were analyzed. Results: The prevalence of H. pylori infection between 1991 and 1993, 1994 and 1996, 1997 and 1999, 2000 and 2002, 2003 and 2005, and 2006 and 2008 were 25.1% (56/223), 23.1% (45/195), 19.3% (28/145), 16.1% (39/242), 11.3% (24/213), and 10.8% (19/176), respectively; these serial decreases in the prevalence over 18 years were statistically significant (p<0.001). Regardless of gender and age, the prevalence of H. pylori infection decreased. This decrease was inversely related to socioeconomic improvement as represented by the per capita gross national income growth of Korea. Conclusion: The prevalence of H. pylori infection has decreased significantly for the past 18 years in Korean children. This decrease might be caused by an improvement in socioeconomic status.

목 적: Helicobacter pylori (H. pylori) 감염 유병률은 사회 경제적 수준에 따라 다르게 나타난다. 최근 우리나라가 경제적 성장을 이루면서 H. pylori 유병률에 변화가 있을 것으로 생각되나 소아를 대상으로 한 보고가 없다. 이번 연구에서는 기능성 반복성 복통 환아를 대상으로 지난 18년간의 H. pylori 유병률 변화를 알아보고자 하였다. 방 법: 1991년 7월부터 2008년 12월까지 반복성 복통으로 서울대병원을 찾은 1,194명(남아 499명, 여아 695명)의 환아들을 대상으로 하였으며 평균나이는 9.2${\pm}$3.1세였다. 모든 환아들은 상부위장관 내시경 검사를 시행 받았으며 CLO test로 H. pylori 감염을 판단하였다. 지난 18년간 H. pylori 감염률의 변화와 성별, 연령에 따른 감염률의 변화를 분석하였다. 결 과: 반복성 복통 환아의 H. pylori 감염률은 1991~1993년 25.1%, 1994~1996년 23.1%, 1997~1999년 19.3%, 2000~2002년 16.1%, 2003~2005년 11.3%, 2006~2008년 10.8%로 지난 18년간 유의하게 감소하였으며(p<0.001) 성별, 연령과 상관없이 모두 감소하였다. 결 론: 반복성 복통 환아에서 지난 18년간 H. pylori 감염률은 유의하게 감소하였으며 이는 사회 경제적 발전에 의한 것으로 생각한다.

Keywords

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