The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
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The Screening of Fermented Medicinal Herbs to Identify Those with Anti-inflammatory Properties

  • Shen, Feng-Yan (Division of Allergy, Immune & Respiratory System, Dept. of Internal Medicine College of Oriental Medicine, Kyung-hee University) ;
  • Ra, Je-Hveon (Dept. of Oriental Physiology, College of Pharmacy, Kyung-hee University) ;
  • Kim, Jin-Ju (Dept. of Oriental Physiology, College of Pharmacy, Kyung-hee University) ;
  • Jung, Sung-Ki (Division of Allergy, Immune & Respiratory System, Dept. of Internal Medicine College of Oriental Medicine, Kyung-hee University)
  • Published : 2009.03.31
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Abstract

Objectives : Consumption of fermented foods has been known to alleviate some of the symptoms of atopy and may limit allergy development, while there are also many medicinal herbs proved to be effective for immunologically-mediated diseases. In this study, we introduced modern zymology to ferment some herbs to see if fermentation has the possibility of increasing the anti-inflammatory effects of medicinal herbs. Interleukin-4 (IL-4) and interferon-gamma $(INF-\gamma)$ have been demonstrated to be the main factors in the pathology of allergic diseases. Methods : We measured the levels of IL-4 and $INF-\gamma$ on concanavalin A-induced BALB/c mice spleen cells, which were subsequently treated with fermented and unfermented herbs. We then compared the fermented groups with unfermented groups to see if the anti-inflammatory effects of the herbs were influenced by fermentation. Results and Conclusions : Our results showed that fermentation had the potential to increase the anti-inflammatory effects of some medicinal herbs, and Astragalus membranaceus and Salvia miltiorrhiza would be the most suitable medicinal herbs for fermentation among the herbs in this study.

Keywords

References

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