YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
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Studies on the Antiinflammatory Compounds from Sorbus Commixta

정공피으로부터 항염증물질의 연구

  • Yun, Young-Gab (Department of Oriental Medical Prescription, School of Oriental Medicine, Wonkwang University) ;
  • Chai, Kyu-Yun (Division of Nanobiochemistry, College of Natural Sciences, Wonkwang University) ;
  • Lee, Kyung-Kwan (Division of Nanobiochemistry, College of Natural Sciences, Wonkwang University) ;
  • Bhatt, Lok Ranjan (Division of Nanobiochemistry, College of Natural Sciences, Wonkwang University) ;
  • Baek, Seung-Hwa (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University)
  • 윤용갑 (원광대학교 한의과대학 방제학교실) ;
  • 채규윤 (원광대학교 자연과학대학 생명나노학부, 한의과대학 방제학교실) ;
  • 이경관 (원광대학교 자연과학대학 생명나노학부, 한의과대학 방제학교실) ;
  • 록란잔밭 (원광대학교 자연과학대학 생명나노학부, 한의과대학 방제학교실) ;
  • 백승화 (원광대학교 한의학전문대학원 한약자원개발학과)
  • Received : 2009.08.13
  • Accepted : 2009.12.27
  • Published : 2009.12.31
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Abstract

Sakuranetin, prunetin and dihydroquercetin were isolated from the methanol extract of Sorbus commixta by 1D/2D-NMR and LC-MASS spectrometry. Medicating these compounds to RAW264.7 cell that was pre-treated by lipopolysaccharide revealed anti-inflammatory effects that greatly inhibited the production of NO (nitric oxide) and PEG2 (prostaglandin E2), which are well known to cause the expression of iNOS (inducible nitric oxide synthase) and COX-2 (Cyclooxygenase-2). These results suggest that these compounds can be used as stable anti-inflammatory materials.

Keywords

References

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