YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Optimum Concentration of the Cd(II)-Quercetin Complexation Reaction

Quercetin의 카드뮴 착물반응에 대한 최적농도

  • Lee, Jeong-Ho (Department of Natural Health Management, Songho College) ;
  • Shin, Sun-Woo (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Baek, Seung-Hwa (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University)
  • 이정호 (송호대학 자연건강관리과) ;
  • 신선우 (원광대학교 한의학전문대학원 한약자원개발학과) ;
  • 백승화 (원광대학교 한의학전문대학원 한약자원개발학과)
  • Received : 2008.12.23
  • Accepted : 2009.07.01
  • Published : 2009.10.31
Download PDF
⟨ Previous Next ⟩

Abstract

The interaction of cadmium (II) ion with quercetin was investigated in aqueous solution at different pH. The quercetin/cadmium stochiometries for cadmium (II) binding have been determined by UV-vis spectrophotometric method. The complexation of Cd(II) ion with 54.72 ${\mu}M$ quercetin (A=1.00793) was formed in 0.2 M $NH_3-0.2$ M $NH_4Cl$ (pH 8.0) buffer solution. 1:1 Cd(II)-complex had a maximum absorbance and showed the bathochromic shift of the long-wavelength band of the UV-vis spectra in the alkaline pH when interacted with quercetin in buffer solution. These results suggest that Cd(II)-quercetin complex has the optimal condition of chelation in basic buffer solution.

Keywords

References

  1. Jin, T. and Nordberg, G. F. : Acta Pharmacol. ed. Toxicol. In Vitro. pp. 137-149 (1983)
  2. Lee, J. H., Shin, S. W. and Baek, S. H. : Optimum concentration of the Cd(II)-protocatechuic acid complex. J. Phram. Soc. Korea 52, 426 (2008)
  3. Souza, R. F. V. D. and Giovani, W. F. D. : Antioxidant properties of complexes of flavonoids with metal ions. Redox Report 9, 97 (2004) https://doi.org/10.1179/135100004225003897
  4. Cornard, J. P., Dangleterre, L. and Lapouge, C. : Computational and spectroscopic characterization of the molecular and electronic structure of the Pb(II)-quercetin complex. J. Phys. Chem. A 109, 10044 (2005) https://doi.org/10.1021/jp053506i
  5. Cornard, J. P. and Merlin, J. C. : Spectroscopic and structural study of complexes of quercetin with Al(III). J. Inorg. Biochem. 92, 19 (2002) https://doi.org/10.1016/S0162-0134(02)00469-5
  6. Le Nest, G., Caille, O., Woudstra, M., Roche, S., Burlat, B., Guerlesquin, F. and Lexa, D. : Zn-polyphenol chelation: complexes with quercetin, (+)-catechin, and derivatives: I optical and NMR studies. Inorg. Chim. Acta 357, 775 (2004) https://doi.org/10.1016/j.ica.2003.09.014
  7. Le Nest, G., Caille, O., Woudstra, M., Roche, S., Burlat, B., Belle, V., Guerlesquin, B. and Lexa, D. : Zn-polyphenol chelation: complexes with quercetin, (+)-catechin, and derivatives: II Electrochemical and EPR studies. Inorg. Chim. Acta 357, 2027 (2004) https://doi.org/10.1016/j.ica.2003.11.046
  8. Dean, J. A. : Lange's Hadbook of Chemistry. McGraw-Hill Book Company, p. 90 (1985)
  9. Oxtoby, D. W. and Freeman, W. A. : Chemistry Science of Change, 3rd eds. Saunders Golden Sunburst Series, p. 317 (1998)
  10. Skoog, D. A., West, D. and Holler, F. J. : Fundamentals of Analytical Chemistry, 6th. ed, Saunders College Publishing, p. 22 (1992)
  11. Bullatov, M. I. and Kalinkin, I. P. K. : Practical Manual of Photometric Analysis, Chemistry, 5th ed., Leningrad (1986)
  12. Dinya, D. and Hetenyi, E. Y. : Topics in Flavonoid Chemistry and Biochemistry, Elservier Scientific Publishing Comp, p. 589 (1975)
  13. Mabry, T. J., Markharn, K. R. and Thomas, M. B. : The Systematic Identification of Flavonoids, Springer-Verlag, p. 253 (1970)
  14. Choi, J. H. and Rhee, S. J. : Effects of green tea catechin on cadmium accumulation in chronic cadmium poisoned rats. Kor. Nutr. Soc. 34, 384 (2001)
  15. Bernal, M., Garcia-Vazquez, J. A., Romero, J., Gomez, C., Duran, M. L., Sousa, A., Sousa-Pedrares, A., Rose, D. L., Maresca, K. P. and Zubieta, J. : Electrochemical synthesis of cobalt, nickel, copper, zinc and cadmium complex with N[(2-hydroxy phenyl)methylidine]-N-'tosylbenzene-1,2-diamine. The crystal structures of {(1,10-phenanthroline)[N-(2-oxophenyl)-methylidine]-N-tosylbenzene-1,2-diaminato}nickel(II) and{(1,10-phenanthroline)[N-(2-oxophenyl)-methylidine]-Ntosylbenzene-1,2-diaminato}copper(II). Inorg. Chem. Acta 295, 39 (1999) https://doi.org/10.1016/S0020-1693(99)00304-7
  16. Bodini, M. E., Copia, G., Tapia, R., Leighton, F. and Herrera, L. : Iron complexes of quercetin in aprotic medium. Redox chemistry and interaction with superoxide anion radical. Polyhedron 18, 2233 (1999) https://doi.org/10.1016/S0277-5387(99)00124-2