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Stability of Paeoniflorin used as Anti-wrinkle Agents in Emulsions

피부 주름 개선 소재인 페오니플로린의 에멀젼 안정성

  • Cho, Wan-Goo (College of Alternative Medicine, Jeonju University) ;
  • Kyung, Kee-Youl (LG H&H Research Institute) ;
  • Yu, Sang-Mun (Cognis Korea R&D Institute, Research Park II, Sung Gyun Gwan University)
  • 조완구 (전주대학교 대체의학대학 기초의과학과) ;
  • 경기열 (엘지 생활건강 기술원) ;
  • 유상문 (코그니스 코리아 연구소)
  • Published : 2009.06.30

Abstract

We have tested the stability of paeoniflorin, a new cosmetic ingredient, extracted from the roots of Paeoniae lactiflora. The stability of aqueous paeoniflorin solution at pH 3, 5 and 7 varied by adding buffer solution was tested at $0^{\circ}C,\;25^{\circ}C,\;40^{\circ}C,\;and\;65^{\circ}C$. The test was performed with or without UV light. The solution of paeoniflorin was stable at pH 3.0, however, the recovery rate of paeoniflorin was 40% at pH 7.0. The stability of paeoniflorin solution was decreased as the pH of paeoniflorin solution was increased by pH 7.0. The effect of storage temperature of paeoniflorin solution shows that the stability of paeoniflorin solution was decreased as the temperature was increased. The stability of paeoniflorin was rather good under UV light than the condition given above $40^{\circ}C$. The stability of paeoniflorin in W/O emulsions shows similar pattern to that of aqueous solution.

Keywords

References

  1. A. M. Klingman and R. M. Laver, Cutaneous aging: The differences between intrinsic aging and photo-aging, J. Cutan. Aging Cosmet. Dermatol., 1, 5 (1988)
  2. W, Meinhard, T.B. Iliana, N. Lale, M. Wenjian, A. S. Lars, R. W. Ziba, S. Jutta and S. K. Karin, Solar UV irritation and dennal photo-aging, J. Photochern. Photobio. B, 63, 41 (2001)
  3. J. M. Lim, M. E. Park, S. H. Lee, S. J. Kang, W. G. Cho and M. J. Rang, The level of UVB-induced DNA damage and chemo-prevention effect of Paeoniflorin in nonnal human epidennal keratinocytes, Mol. Cell. Toxicol., 1(2) 111 (2005)
  4. N. G. Kang, J. M. Lim, M. Y. Chang, S. G. Park, W. G. Cho and S. Y. Choi, Modified Superoxide Dismutase for Cosmeceuticals, IFSCC Magazine, 8(2), 87 (2005)
  5. H. S. Cho, M. H. Lee, J. W. Lee, K. O. No, S. K. Park, H. S. Lee, S. J. Kang, W. G. Cho, H. J. Park, K. W. Oh and J. T. Hong, Anti-wrinkling effects of the mixture of vitamin C, vitamin E, pycnogenol and evening primrose oil and mechanism on hairless mouse skin, J. Photoderm. Photoimmu. & Photomedicine, 23, 155 (2007) https://doi.org/10.1111/j.1600-0781.2007.00298.x
  6. M. H. Jin, M. H. Jung, Y. H. Lim, S. H. Lee, S. J. Kang and W. G. Cho, Effect of Angelica against skin photo-aging, J. Cosmet. Sci. Kor., 31(3), 227 (2005)
  7. W. G. Cho, S. K. Han, J. H. Sin and J.W. Lee, Antioxidant of heating pork and anti-oxidative activities of Rubus coreanus Miq. extracts, J. Korean Soc. Food Sci. Nutr., 37(7), 820 (2008) https://doi.org/10.3746/jkfn.2008.37.7.820
  8. S. Lee, J. M. Lim, M. H. Jin, H. K. Park, E.J. Lee, S, J. Kang, Y. S. Kim and W. G. Cho, Partially purified paeoniflorin exerts protective effects on UV -induced DNA damage and reduces facial wrinkles in human skin, J. Cosmet. Sci., 57, 57 (2006)
  9. K. H. Sung, Phannaceutical Characteristics and analysis of garlic extract, J. Kor. Oil Chern. Soc., 24(3), 301 (2007)
  10. K. H. Sung, A Study on the phannaceutical characteristics & analysis of glycyrrhizin extract, J. Kor. Oil Chern. Soc., 23(3), 215 (2006)
  11. O. K. Kim, Antidiabetic and antioxidative effects of coml fructus in streptozotocin-induced diabetic rats J. Kor Oil Chern. Soc. 22(2), 157 (2005)
  12. N. H. Jeong, Y. J. Mun, H. W. Lee and K. D. Nam, The evaluation for stabilization and application of microemulsion containing isoflavone J. Kor. Oil Chern. Soc. 19(3), 167 (2002)
  13. S. Al-Edresi and S. Baie, Fonnulation and stability of whitening VCO-in-water nano-cream, Int. J. Pharrn., 373(1,2), 174 (2009) https://doi.org/10.1016/j.ijpharm.2009.02.011
  14. P. Piclin, M. Gaperlin and V. Kmetec, Stability of ascorbyl palmitate in topical microemulsions, Int. J. Pharrn., 222(2), 271 (2001) https://doi.org/10.1016/S0378-5173(01)00715-3
  15. A. Akhavan and J. Levitt, Assessing retinol stability in a hydroquinone 4%/retinol 0.3% cream in the presence of antioxidants and sunscreen under simulated-use conditions: a pilot study, Clin. Ther., 30(3), 543 (2008) https://doi.org/10.1016/j.clinthera.2008.03.010
  16. E. M. Paliakov, B. S. Crow, M. J. Bishop, D. Norton, J. George and J. A. Bralley, Rapid quantitative determination of fat-soluble vitamins and coenzyme Q-10 in human serum by reversed phase ultra-high pressure liquid chromatography with UV detection, J. Chromatogr., B, 877(1-2), 89 (2009) https://doi.org/10.1016/j.jchromb.2008.11.012
  17. S. A. Wissing and R. H. Muller, Cosmetic applications for solid lipid nanoparticles (SLN), Int. J. Phann., 254(1), 65 (2003) https://doi.org/10.1016/S0378-5173(02)00684-1