The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
권호 표지
DOI QR코드

DOI QR Code

Concentration of Hazardous Substances of Before/after a Decoction- In Prescription of High Frequency -

전탕 전과 후의 한약재 및 처방에 포함된 위해물질의 농도변화 -다빈도 한약 처방을 중심으로-

  • Seo, Chang-Seob (Division of Standard Research, Korea Institute of Oriental Medicine) ;
  • Huang, Dae-Sun (Division of Standard Research, Korea Institute of Oriental Medicine) ;
  • Lee, Jun-Kyoung (Division of Standard Research, Korea Institute of Oriental Medicine) ;
  • Ha, Hye-Kyoung (Division of Standard Research, Korea Institute of Oriental Medicine) ;
  • Chun, Jin-Mi (Division of Standard Research, Korea Institute of Oriental Medicine) ;
  • Um, Young-Ran (Division of TKM Integrated Research, Korea Institute of Oriental Medicine) ;
  • Jang, Seol (Herbal Quality Control Center, Korea Institute of Oriental Medicine) ;
  • Shin, Hyun-Kyoo (Division of Standard Research, Korea Institute of Oriental Medicine)
  • 서창섭 (한국한의학연구원 표준화연구본부) ;
  • 황대선 (한국한의학연구원 표준화연구본부) ;
  • 이준경 (한국한의학연구원 표준화연구본부) ;
  • 하혜경 (한국한의학연구원 표준화연구본부) ;
  • 천진미 (한국한의학연구원 표준화연구본부) ;
  • 엄영란 (한국한의학연구원 한의융합연구본부) ;
  • 장설 (한국한의학연구원 한약품질관리센터) ;
  • 신현규 (한국한의학연구원 표준화연구본부 한약EBM연구센터)
  • Published : 2009.06.30
Download PDF
⟨ Previous Next ⟩

Abstract

Objectives: To compare the contents of hazardous substances before/after a decoction. Methods : The heavy metal contents before/after a decoction were measured by Inductively Coupled Plasma Atomic Emission Spectrometer (ICP-AES) and mercury analyzer. In order to analyze pesticides in 6 samples we used simultaneous multi-residue analysis of pesticides by GC/ECD, which was followed by GC/MSD analysis to confirm the identity of the detected pesticide in each sample. In addition, the contents of sulfur dioxide (S02) were performed by Monier-Williams distillation method. Results : 1. The mean values of heavy metal contents (mg/kg) for the samples were as follows: Socheongryong-tang (before decoction - Pb; 1.115, Cd; 0.179, As; 0.069 and Hg; 0.028, after decoction - Pb; 0.110, Cd; 0.011, As; 0.005 and Hg; 0.002), Insampaedok-san (before decoction - Pb; 1.207, Cd; 0.148, As; 0.171 and Hg; 0.026, after decoction - Pb; 0.075, Cd; 0.006, As; not detected and Hg; O.OOD, Oryung-san (before decoction - Pb; 1.955, Cd; 0.430, As; 0.063 and Hg; 0.027, after decoction - Pb; 0.083, Cd; 0.013, As; 0.006 and Hg; 0.002), Hwangryunhaedok-tang (before decoction - Pb; 1.825, Cd; 0.210, As; 0.050 and Hg; 0.009, after decoction - Pb; 0.107, Cd; 0.010, As; 0.005 and Hg; O.OOD, Bangpungtongseong-san (before decoction - Pb; 1.740, Cd; 0.162, As; 0.585 and Hg; 0.018, after decoction - Pb; 0.041, Cd; 0.006, As; 0.022 and Hg; not detected) and Oyaksungi-san (before decoction - Pb; 1.199, Cd; 0.183, As; 0.321 and Hg; 0.031, after decoction - Pb; 0.096, Cd; 0.008, As; 0.021 and Hg; 0.0004). 2. Contents (mg/kg) of sulfur dioxide (S0$_2$) before a decoction in Socheongryong-tang, Insampaedok-san, Oryung-san, Hwangryunhaedok-tang, Bangpungtongseong-san and Oyaksungi-san exhibited 3.2, 5.7, 4.5, 49.8, 7.8 and 22.4, respectively. However, contents of sulfur dioxide after a decoction in all samples were not detected. 3. Contents (mg/kg) of residual pesticides before/after a decoction in all samples were not detected. Conclusions : These results will be used to establish a criterion of heavy metals, residual pesticides and sulfur dioxide.

Keywords

References

  1. Oh CS, Seo DW, Yook CS, Lee YJ, Chang SY, Ze KR, Park JY, Lee JP, Seong RS, Park JY, Ko SK, Lee PJ. The variation of residual sulfur dioxide and marker components of herbal medicines during drying process. Kor J Pharmacogn. 2007 ; 38 : 299-304.
  2. Yim OK, Han EJ, Chung JY, Park KS, Kang IH, Kang SJ, Kim YJ. The monitoring of some heavy metals in oriental herbal medicines and their intake rates. Anal Sci Technol. 2009 ; 22 : 129-35.
  3. Massaro EJ. Handbook of human toxicology. New York : Boca Raton Press. 1990 : 149-88.
  4. 이병철. 定量分析法에 依한 國.外産 韓藥材의 無機質成分 含量에 關한 硏究. 경희대학교대학원 석사학위논문. 1995.
  5. WHO. Lead (Environmental Health Criteria 3). WHO. 1997 : 44-54.
  6. Conor Reilly. Metal contamination of food. London : Applied Science Publisher LTD. 1980 : 119-22.
  7. Conor Reilly. Metal contamination of food. 2nd edition. London : Elsevier Science Publishers LTD. 1991 : 95-8.
  8. Codex Alimentarius Commission, Contaminants : Joint FAO/WHO food standards program. Codex Alimentarius. Vol XVII, Rome. 1984 : 1-33.
  9. KFDA. A notice from 2008-2. Seoul Korea : Korea Food and Drug Administration. 2008.
  10. 승정자. 극미량 원소의 영양. (주)민음사. 1984 : 310.
  11. 승정자. 극미량 원소의 영양. (주)민음사. 1984 : 321-2.
  12. 승정자. 극미량 원소의 영양. (주)민음사. 1984 : 54.
  13. 승정자. 극미량 원소의 영양. (주)민음사. 1984 : 225.
  14. 박성수. GC/MS를 이용한 뇨의 유해화학물질 및 유기인계화합물의 대사물에 관한 연구. 건국대학교 대학원 박사학위논문. 1998.
  15. Rogan WJ, Gladen BC, McKinney JD, Carreras N, Hardy P, Thullen J, Tingelstad J, Tully M. Polychlorinated biphenyls (PCBs) and dichlorodiphenyl dichloroethene (DDE) in human milk: effects of maternal factors and previous lactation. Am J Public Health. 1986 ; 76 : 172-7. https://doi.org/10.2105/AJPH.76.2.172
  16. Schecter A, Li L. Dioxins, dibenzofurans, dioxinlike PCBs, and DDE in U.S. Fast Food. Chemosphere. 1995 ; 34 : 1449-57. https://doi.org/10.1016/S0045-6535(97)00441-4
  17. Stevens MF, Ebell GF, Psaila-Savona P. Organochlorine pesticides in Western Australian nur- sing mothers. Med J Aust. 1993 ; 158 : 238-41.
  18. Kutz FW, Wood PH, Bottimore DP. Organochlorine pesticides and polychlorinated biphenyls in human adipose tissue. Rev Environ Contam Tocicol. 1991 ; 120 : 1-82.
  19. KFDA. A notice from 2008-23. Seoul, Korea : Korea Food and Drug Administration. 2008.
  20. KFDA. A notice from 2008-3. Seoul, Korea : Korea Food and Drug Administration. 2008.
  21. Kim HY, Lee YJ, Hong KH, Kwon YK, Ko HS, Lee YK, Lee CW. Studies on the contents of naturally occuring of sulfite in foods. Korean J Food Sci Technol. 2000 ; 32 : 544-9.
  22. Kim HJ, Kim YK, Smith M. Sulfite analysis by ion exclusion chromatography: Application to the food and beverage industries. Food Technol. 1988 ; 11 : 113-5.
  23. Holak W, Patel B. Differential pulse polarographic determination of sulfites in foods. J Assoc Off Anal Chem. 1987 ; 70 : 572-8.
  24. Kim HJ, Conca KR, Richardson MJ. Determination of sulfur dioxide in grapes, comparison of the Monier-Williams method and two ion exclusion chromatographic methods. J Assoc Off Anal Chem. 1990 ; 73 : 983-9.
  25. Kang KJ, Oh GS, Cho JH, Kim HI, Choi YH, Kim YJ, Park SL, Ko KH, Jeoung JH, Chung YC. Naturally occurring of sulfur dioxide and improvement of its cetermination method in medical herbs (crude drug materials). Annual Report of KFDA. 1999 ; 3 : 313-26.
  26. Lawrence JF, Chadha RK. Determination of sulfite in foods by headspace liquid chromatography. J Assoc Off Anal Chem. 1988 ; 71 : 930-3.
  27. Perfetti GA, Joe FL, Diachenko GW. Liquid chromatographic determination of sulfite in grapes and selected grape products. J Assoc Off Anal Chem. 1989 ; 72 : 903-6.
  28. Holak W, Specchio J. Determination of sulfites in foods by simultaneous nitrogen purging and differential pulse polarography. J Assoc Off Anal Chem. 1989 ; 72 : 476-80.
  29. Sullivan JJ, Hollingworth TA, Wekell MM, Newton RT, Larose JE. Determination of sulfite in food by flow injection analysis. J Assoc Off Anal Chem. 1986 ; 69 : 542-6.
  30. Cho JH, Kim DH, Seong RS, Oh MH, Kang IH, Shim YH, Kim EK, Cho CH, Ji SK, Lee CK, Song YS, Oh JS, Won DH, Myung SW, Kim NJ. Studies on monitoring hazardous substances of natural medicines. Annual Report of KFDA. 2000 ; 4 : 567-82.
  31. Kim CM, song BJ, Na HS. Determination of sulfite contents in medicinal herbs. J Korean Soc Food Sci Nutr. 2000 ; 29 : 375-9.
  32. Seo CS, Huang DS, Lee JK, Ha HK, Chun JM, Um YR, Jang S, Shin HK. Concentration of heavy metals, residual pesticides and sulfur dioxide of before/after a decoction. Kor J Herbology. 2008 ; 23 :51-8.
  33. Seo CS, Huang DS, Lee JK, Ha HK, Chun JM, Um YR, Jang S, Shin HK. Concentration of heavy metals, residual pesticides and sulfur dioxide of before/after a decoction - In prescription of digestive system -. Kor J Herbology. 2009 ; 24(1) : 111-9.
  34. 서창섭, 황대선, 이준경, 하혜경, 천진미, 엄영란, 장설, 김종열, 이시우, 신현규. 중금속, 잔류농약 및 잔류이산화황의 전탕 전, 후의 농도 변화 - 다빈도 태음인 사상처방을 중심으로 -. 사상체질의학회지. 2009 ; 21 : 237-46.
  35. Korean Code of Food. Korea Food & Drug Administration. 2005.