Journal of Acupuncture Research

Korean Acupuncture & Moxibustion Medicine Society (대한침구의학회)
권호 표지

Antidepressant Effect of the Subchronic Administration of the Methanolic Extract of Wild-ginseng and Cultivated-ginseng in Mice Tail Suspension Test

산삼과 인삼 메탄올 추출물 아만성 복용의 Mice Tail Suspension Test에서의 항우울 효과에 대한 비교연구

  • Kwon, Sun-Oh (Acupuncture and Meridian Science Research Center, Kyung Hee University) ;
  • Choi, Soo-Min (Acupuncture and Meridian Science Research Center, Kyung Hee University) ;
  • Kim, Myung-Hwan (Acupuncture and Meridian Science Research Center, Kyung Hee University) ;
  • Lee, Bom-Bi (Acupuncture and Meridian Science Research Center, Kyung Hee University) ;
  • Park, Moo-Won (Acupuncture and Meridian Science Research Center, Kyung Hee University) ;
  • Lee, Hye-Jung (Acupuncture and Meridian Science Research Center, Kyung Hee University) ;
  • Park, Hi-Joon (Acupuncture and Meridian Science Research Center, Kyung Hee University) ;
  • Hahm, Dae-Hyun (Acupuncture and Meridian Science Research Center, Kyung Hee University)
  • 권선오 (경희대학교 침구경락과학연구센터) ;
  • 최수민 (경희대학교 침구경락과학연구센터) ;
  • 김명환 (경희대학교 침구경락과학연구센터) ;
  • 이봄비 (경희대학교 침구경락과학연구센터) ;
  • 박무원 (경희대학교 침구경락과학연구센터) ;
  • 이혜정 (경희대학교 침구경락과학연구센터) ;
  • 박히준 (경희대학교 침구경락과학연구센터) ;
  • 함대현 (경희대학교 침구경락과학연구센터)
  • Received : 2009.07.31
  • Accepted : 2009.08.07
  • Published : 2009.08.20
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Abstract

Objectives : The antidepressant effect of the subchronic administration of the methanolic extract of wild ginseng(WG) was investigated compared with that of cultivated ginseng(CG, panax ginseng) extract. Methods : To assess the antidepressant effect of the ginseng extracts, tail suspension test(TST) was executed in mice after daily administration of WG or CG extract for five consecutive days. Results : The WG extract at daily dose of 600mg/kg significantly reduced the total duration of immobility in the TST, whereas there was no significant reduction at daily dose of 300mg/kg WG and 600mg/kg CG. There were no individual differences between experimental groups in open field test (OFT) to evaluate psychostimulant effects of WG or CG extract. In the high performance liquid chromatography(HPLC) analysis of the extracts, it was found that WG included four times more ginsenoside Rg1 and Re, three times more Rf, and six times more Rb1 and Rc than CG. Conclusions : It is suggested that WG extract has stronger antidepressant effect than CG extract, which means it includes more antidepressant compounds than CG.

Keywords

References

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