Tuberculosis and Respiratory Diseases

The Korean Academy of Tuberculosis and Respiratory Diseases (대한결핵및호흡기학회)
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Recovery Rate of Nontuberculous Mycobacteria and the Clinical Course of Nontuberculous Mycobacterial Pulmonary Disease at a Secondary Hospital

일개 2차 의료기관에서의 비결핵성 마이코박테리아 분리비율 및 폐질환의 임상 경과

  • Lee, Jae Kwang (Department of Internal Medicine, Daegu Fatima Hospital) ;
  • Kwon, Hwuck Young (Department of Internal Medicine, Daegu Fatima Hospital) ;
  • Kwon, Jong Kyu (Department of Internal Medicine, Daegu Fatima Hospital) ;
  • Lee, Hwa Jeong (Department of Internal Medicine, Daegu Fatima Hospital) ;
  • Lee, Dong Wook (Department of Internal Medicine, Daegu Fatima Hospital) ;
  • Lee, Yu Jin (Department of Internal Medicine, Daegu Fatima Hospital) ;
  • Yoon, Kyung Hwa (Department of Internal Medicine, Daegu Fatima Hospital) ;
  • Song, Do Young (Department of Clinical Pathology, Daegu Fatima Hospital) ;
  • Lee, Byung Ki (Department of Internal Medicine, Daegu Fatima Hospital) ;
  • Kim, Yeon Jae (Department of Internal Medicine, Daegu Fatima Hospital)
  • Received : 2009.05.29
  • Accepted : 2009.07.17
  • Published : 2009.09.30
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Abstract

Background: To examine the recovery rate of nontuberculous mycobacteria (NTM) from respiratory specimens and the clinical course of NTM pulmonary disease at a 700-bed secondary hospital. Methods: This study analyzed the results of 843 acid-fast bacilli (AFB) culture-positive respiratory specimens from 650 subjects collected between May 2003 and April 2008. In addition, the clinical course of NTM pulmonary disease, diagnosed using criteria established by the American Thoracic Society, was examined. Results: There were 67 (7.9%) NTM isolates recovered from 52 (8.0%) subjects. Among the 535 AFB smear-positive specimens, 34 (6.3%) NTM isolates were recovered. There were 33 (10.7%) NTM isolates were recovered from 308 AFB smear-negative specimens. Of 52 subjects with isolated NTM, M. intracellulare was the most common species at 73.1% (n=33), followed by M. kansassi (n=7), M. abscessus (n=2), M. fortuitum (n=2), and M. avium (n=1). Sixteen (30.8%) patients had NTM pulmonary disease and the most common causative organism was M. intracellulare (n=14, 87.5%). Of these, 6 cases attained negative conversion in culture, 4 cases failed to attain negative conversion because of poor cooperation or expiration from complicated underlying lung disease, and 5 cases were transferred to a higher-grade hospital. Conclusion: The recovery rate of NTM from respiratory specimens was relatively low and the most common species was M. intracellulare. Patients with NTM pulmonary disease showed variable clinical outcomes.

Keywords

References

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