References
- Li CP, Li RC. An introductory note to ginseng. Am. J. Chin. Med. 1: 249-61 (1973) https://doi.org/10.1142/S0192415X73000279
- Lee TK, Johnke RM, Allison RR, OBrien KF, Dobbs Jr L.J. Radioprotective potential of ginseng. Mutagenesis. 20: 237-243 (2005) https://doi.org/10.1093/mutage/gei041
- Kennedy DO, Scholey AB. Ginseng: potential for the enhancement of cognitive performance and mood. Pharmacol Biochem Behav. 75: 687-700 (2003) https://doi.org/10.1016/S0091-3057(03)00126-6
- Attele AS, Wu JA, Yuan CS. Ginseng pharmacology: multiple constituents and multiple actions. Biochem. Pharmacol. 58: 1685-93 (1999) https://doi.org/10.1016/S0006-2952(99)00212-9
- Scaglione F, Ferrara F, Dugnani S, Falchi M, Santoro G, Fraschini F. Immunomodulatory effects of two extracts of Panax ginseng C. A. Meyer. Drugs Exp Clin Res. 16: 537-42 (1990)
- See DM, Broumand N, Sahl L, Tilles JG. In vitro effects of echinacea and ginseng on natural killer and antibody-dependent cell cytotoxicity in healthy subjects and chronic fatigue syndrome or acquired immunodeficiency syndrome patients. Immunopharmacol. 35: 229-35 (1997) https://doi.org/10.1016/S0162-3109(96)00125-7
- Singh VK, Agarwhal SS, Gupta BM. Immunomodulatory activity of Panax ginseng extract. Planta Med. 50: 462-65 (1984) https://doi.org/10.1055/s-2007-969773
- Fulder SJ. Ginseng and the hypothalamic-pituitary control of stress. Am J Chin Med. 9: 112-18 (1981) https://doi.org/10.1142/S0192415X81000159
- Hiai S, Yokoyama H, Oura H, Yano S. Stimulation of pituitary-adrenocortical system by ginseng saponin. Endocrinol Jpn 26: 661-65 (1979) https://doi.org/10.1507/endocrj1954.26.661
- Nocerino E, M Amato, Izzo AA. The aphrodisiac and adaptogenic properties of ginseng. Fitoterapia 71(Suppl.): 1S-5S (2000) https://doi.org/10.1016/S0367-326X(00)00170-2
- Shibata S, Tanaka O, Soma K, Ando T, Iida Y, Nakamura H. Studies on saponins and sapogenins of ginseng. The structure of panaxatriol. Tetrahedron Lett. 42: 207-13 (1965)
- Shibata S, Tanaka O, Ando T, Sado M, Tsushima S, Ohsawa T. Chemical studies on oriental plant drugs. XIV. Protopanaxadiol, a genuine sapogenin of ginseng saponins. Chem Pharm. Bull 14: 595-600 (1966) https://doi.org/10.1248/cpb.14.595
- Matsuda H, Namba K, Fukuda S, Tani T, Kubo M. Pharmacological study on Panax ginseng C. A. Meyer. IV. Effects of red ginseng on experimental disseminated intravascular coagulation. (3). Effect of ginsenoside-Ro on the blood coagulative and fibrinolytic system. Chem Pharm Bull. 34: 2100-4 (1986) https://doi.org/10.1248/cpb.34.2100
- Wang X, Sakuma T, Asafu-Adjaye E, Shiu GK. Determination of ginsenosides in plant extracts from Panax ginseng and Panax quinquefolius L. by LC/MS/MS. Anal Chem. 71: 1579-84 (1999) https://doi.org/10.1021/ac980890p
- Kitagawa I, Yoshikawa M, Yoshihara M, Hayashi T, Taniyama T. Chemical studies on crude drug precession. I. On the constituents of ginseng radix rubura (I). Yakugaku Zasshi 103: 612-622 (1983)
- Kown SW, Han SB, Park IH, Kim JM, Park MK, Park JH. Liquid chromatographic determination of less polar ginsenosides in processed ginseng. J Chromatogr. A 921: 335-339 (2001) https://doi.org/10.1016/S0021-9673(01)00869-X
- Kim WY, Kim JM, Han SB, Lee SK, Kim ND, Park MK, Kim CK, Park JH. Steaming of ginseng at high temperature enhances biological activity. J Nat Prod. 63: 1702-4 (2000) https://doi.org/10.1021/np990152b
- Konno C, Sugiyama K, Kano M, Takahashi M, Hikino H. Isolation and hypoglycemic activity of panaxans A, B, C, D and E, glycans of Panax ginseng roots. Planta Med. 50: 434-439 (1984) https://doi.org/10.1055/s-2007-969757
- Li LG. Determination of the polysaccharide content in Jilin red ginseng and Korean ginseng] Zhong Yao Tong Bao. 12: 40-1 (1987)
- Chang YS, Seo EK, Gyllenhaal C, Block KI. Panax ginseng: a role in cancer therapy? Integr Cancer Ther. 2: 13-33 (2003) https://doi.org/10.1177/1534735403251167
- Helms S. Cancer prevention and therapeutics: Panax ginseng. Altern. Med Rev. 9: 259-74 (2004)
- Wakabayashi C, Hasegawa H, Murata J, Saiki I, In vivo antimetastatic action of ginseng protopanaxadiol saponins is based on their intestinal bacterial metabolites after oral administration. Oncol Res1998; 9: 411-7 (1998)
- Xie JT, Mchendale S, Yuan CS. Ginseng and diabetes. Am. J. Chin. Med. 33: 397-404 (2005) https://doi.org/10.1142/S0192415X05003004
- Yokozawa T, Kobayashi T, Oura H, Kawashima Y. Studies on the mechanism of the hypoglycemic activity of ginsenoside-Rb2 in streptozotocin-diabetic rats. Chem Pharm Bull. 33: 869-72 (1985) https://doi.org/10.1248/cpb.33.869
- Park EK, Choo MK, Han MJ, Kim DH. Ginsenoside Rh1 possesses antiallergic and anti-inflammatory activities. Int Arch Allergy Immunol. 133: 113-120 (2004) https://doi.org/10.1159/000076383
- Park EK, Choo MK, Kim EJ, Han MJ, Kim DH. Antiallergic activity of ginsenoside Rh2. Biol. Pharm. Bull 2003; 26:1581-4 (2003) https://doi.org/10.1248/bpb.26.1581
- Choo MK, Park EK, Han MJ, Kim D-H. Antiallergic activity of ginseng and its ginsenosides. Planta Med. 69: 518-522 (2003) https://doi.org/10.1055/s-2003-40653
- Kim ND, Kang SY, Kim MJ, Park JH, Schini-Kerth VB. The ginsenoside Rg3 evokes endothelium-independent relaxation in rat aortic rings: role of K+ channels. Eur J Pharmacol 1999; 367: 51-57 https://doi.org/10.1016/S0014-2999(98)00899-1
- Wu JY, Gardner BH, Murphy CI, Seals JR, Kensil CR. Rec chia, J., Beltz, G.A., Newman, G.W., Newman, M.J., Saponin adjuvant enhancement of antigen-specific immune responses to an experimental HIV-1 vaccine. J Immunol. 148: 1519-1525 (1992)
- Rivera E, Hu S, Concha C. Ginseng and aluminium hydroxide act synergistically as vaccine adjuvants.Vaccine 21:1149-57 (2003) https://doi.org/10.1016/S0264-410X(02)00518-2
- Lee EJ, Ko E, Lee J, Rho S, Ko S, Shin MK, Min BI, Hong MC, Kim SY, Bae H. Ginsenoside Rg1 enhances CD4(+) Tcell activities and modulates Th1/Th2 differentiation. Int. Immunopharmacol. 4: 235-44 (2004) https://doi.org/10.1016/j.intimp.2003.12.007
- Park EK, Choo MK, Oh JK, Ryu JH, Kim DH. Ginsenoside Rh2 reduces ischemic brain injury in rats. Biol. Pharm. Bull. 27: 433-6 (2004) https://doi.org/10.1248/bpb.27.433
-
Shieh PC, Tsao CW, Li JS, Wu HT, Wen YJ, Kou DH, Cheng JT. Role of pituitary adenylate cyclase-activating polypeptide (PACAP) in the action of ginsenoside
$\text Rh_2$ against betaamyloid- induced inhibition of rat brain astrocytes. Neurosci Lett. 434: 1-5 (2008) https://doi.org/10.1016/j.neulet.2007.12.032 - Ahn JY, Song JY, Yun YS, Jeong G, Choi IS. Protection of Staphylococcus aureus-infected septic mice by suppression of early acute inflammation and enhanced antimicrobial activity by ginsan. FEMS Immunol. Med Microbiol. 46: 187-97 (2006)
- Konno C, Sugiyama K, Kano M, Takahashi M, Hikino H. Isolation and hypoglycemic activity of panaxans A, B, C, D and E, glycans of Panax ginseng roots. Planta Med. 50: 434-439 (1984) https://doi.org/10.1055/s-2007-969757
- Ng TB, Yeung HW. Hypoglycemic constituents of Panax ginseng. Gen Pharmacol. 16: 549-52 (1985) https://doi.org/10.1016/0306-3623(85)90140-5
- Shin HJ, Kim YS, Kwak YS, Song YB, Kim YS, Park JD. Enhancement of antitumor effects of paclitaxel (taxol) in combination with red ginseng acidic polysaccharide (RGAP). Planta Med. 70: 1033-38 (2004) https://doi.org/10.1055/s-2004-832643
- Lee YS, Chung IS, Lee IR, Kim KH, Hong WS, Yun YS. Activation of multiple effector pathways of immune system by the antineoplastic immunostimulator acidic polysaccharide ginsan isolated from Panax ginseng. Anticancer Res. 7:323-31 (1987)
- Kobashi K, Kobashi K, Akao T. Relation of intestinal bacteria to pharmacological effects of glycosides. Bioscience Microflora. 16: 1-7 (1997) https://doi.org/10.12938/bifidus1996.16.1
- Kim DH, Kim DH. Herbal medicines are activated by intestinal microflora. Nat Prod Sci. 8: 35-43 (2002)
- Tawab MA, Bahr U, Karas M, Wurglics M. Schubert-Zsilavecz M.Degradation of ginsenosides in humans after oral administration. Drug Metab. Dispos. 31: 1065-71 (2003) https://doi.org/10.1124/dmd.31.8.1065
- Karikura M, Miyase T, Tanizawa H, Taniyama T, Takino Y. Studies on absorption, distribution, excretion and metabolism of ginseng saponins. VII. Comparison of the decomposition modes of ginsenoside-Rb1 and -Rb2 in the digestive tract of rats. Chem Pharm Bull. 39: 2357-61 (1991) https://doi.org/10.1248/cpb.39.2357
- Lee HU, Bae EA, Han MJ, Kim NJ, Kim DH. Hepatoprotective effect of ginsenoside Rb1 and compound K on tert-butyl hydroperoxide-induced liver injury. Liver Int. 25: 1069-73 (2005) https://doi.org/10.1111/j.1478-3231.2005.01068.x
- Akao T, Kida H, Kanaoka M, Hattori M, Kobashi K. Intestinal bacterial hydrolysis is required for the appearance of compound K in rat plasma after oral administration of ginsenoside Rb1 from Panax ginseng. J Pharm Pharmacol. 50: 1155-60 (1998) https://doi.org/10.1111/j.2042-7158.1998.tb03327.x
-
Akao T, Kanaoka M, Kobashi K. Appearance of compound K, a major metabolite of ginsenoside
$\text Rb_1$ by intestinal bacteria, in rat plasma after oral administration--measurement of compound K by enzyme immunoassay. Biol Pharm Bull. 21: 245-9 (1998) https://doi.org/10.1248/bpb.21.245 - Lee SJ, Ko WG, Kim JH, Sung JH, Moon CK, Lee BH. Induction of apoptosis by a novel intestinal metabolite of ginseng saponin via cytochrome c-mediated activation of caspase-3 protease. Biochem Pharmacol. 60: 677-85 (2000) https://doi.org/10.1016/S0006-2952(00)00362-2
- Kim YS, Kim JJ, Cho KH, Jung WS, Moon SK, Park EK, Kim DH. Biotransformation of ginsenoside Rb1, crocin, amygdalin, geniposide, puerarin, ginsenoside Re, hesperidin, poncirin, glycyrrhizin, and baicalin by human fecal microflora and its relation to cytotoxicity against tumor cells. J Microbiol Biotechnol. 18: 1109-14 (2008)
- Tatsuka M, Maeda M, Ota T. Anticarcinogenic effect and enhancement of metastatic potential of BALB/c 3T3 cells by ginsenoside Rh(2). Jpn J Cancer Res. 92: 1184-9 (2001) https://doi.org/10.1111/j.1349-7006.2001.tb02138.x
- Shibata S. Chemistry and cancer preventing activities of ginseng saponins and some related triterpenoid compounds. J Korean Med Sci. 16 Suppl: S28-37 (2001) https://doi.org/10.3346/jkms.2001.16.S.S28
-
Shin JE, Park EK, Kim EJ, Hong YH, Lee KT, Kim DH. Cytotoxicity of compound K and ginsenoside
$\text Rh_2$ , main biotransformants of ginseng saponins by bifidobacteria, against some tumor cells. J Ginseng Res. 27: 129-134. (2003) https://doi.org/10.5142/JGR.2003.27.3.129 - Choo MK, Sakurai H, Kim DH, Saiki I. A ginseng saponin metabolite suppresses tumor necrosis factor-alpha-promoted metastasis by suppressing nuclear factor-kappaB signaling in murine colon cancer cells. Oncol Rep. 19: 595-600 (2008)
- Nakata H, Kikuchi Y, Tode T, Hirata J, Kita T, Ishii K, Kudoh K, Nagata I, Shinomiya N. Inhibitory effects of ginsenoside Rh2 on tumor growth in nude mice bearing human ovarian cancer cells. Jpn J Cancer Res. 89: 733-40 (1998) https://doi.org/10.1111/j.1349-7006.1998.tb03278.x
-
Sato K, Mochizuki M, Saiki I, Yoo YC, Samukawa K, Azuma I. Inhibition of tumor angiogenesis and metastasis by a saponin of Panax ginseng, ginsenoside-
$\text Rb_2$ . Biol Pharm. Bull. 17: 635-9 (1994) https://doi.org/10.1248/bpb.17.635 -
Mochizuki M, Yoo YC, Matsuzawa K, Sato K, Saiki I, Tonooka S, Samukawa K, Azuma I. Inhibitory effect of tumor metastasis in mice by saponins, ginsenoside-
$\text Rb_2$ , 20(R)- and 20(S)-ginsenoside-Rg2, of red ginseng. Biol Pharm Bull. 18: 1197-202 (1995) https://doi.org/10.1248/bpb.18.1197 -
Shin YW, Bae EA, Kim SS, Lee YC, Kim DH. Effect of gin senoside
$\text Rb_1$ and compound K in chronic oxazoloneinduced mouse dermatitis. Int Immunopharmacol. 5: 1183-91 (2005) https://doi.org/10.1016/j.intimp.2005.02.016 - Choo MK, Park EK, Han MJ, Kim DH. Antiallergic activity of ginseng and its ginsenosides. Planta Med. 69: 518-22 (2003) https://doi.org/10.1055/s-2003-40653
-
Bae EA, Park SY, Kim DH. Constitutive beta-glucosidases hydrolyzing ginsenoside
$\text Rb_1$ and$\text Rb_2$ from human intestinal bacteria. Biol Pharm Bull. 23: 1481-5 (2000) https://doi.org/10.1248/bpb.23.1481 -
Bae EA, Han MJ, Kim EJ, Kim DH. Transformation of ginseng saponins to ginsenoside
$\text Rh_2$ by acids and human intestinal bacteria and biological activities of their transformants. Arch Pharm Res. 27: 61-7 (2004) https://doi.org/10.1007/BF02980048 -
Bae EA, Han MJ, Choo MK, Park SY, Kim DH. Metabolism of 20(S)- and 20(R)-ginsenoside
$\text Rg_3$ by human intestinal bacteria and its relation to in vitro biological activities. Biol Pharm Bull 25: 58-63 (2002) https://doi.org/10.1248/bpb.25.58 -
Shin HY, Park SY, Sung JH, Kim DH. Purification and characterization of alpha-L-arabinopyranosidase and alpha-Larabinofuranosidase from Bifidobacterium breve K-110, a human intestinal anaerobic bacterium metabolizing ginsenoside
$\text Rb_2$ and Rc. Appl Environ Microbiol. 69: 7116-23 (2003) https://doi.org/10.1128/AEM.69.12.7116-7123.2003 - Bae EA, Shin JE, Kim DH. Metabolism of ginsenoside Re by human intestinal microflora and its estrogenic effect. Biol Pharm Bull. 28: 1903-8 (2005) https://doi.org/10.1248/bpb.28.1903
-
Park SY, Bae EA, Sung JH, Lee SK, Kim DH. Purification and characterization of ginsenoside
$\text Rb_1$ -metabolizing betaglucosidase from Fusobacterium K-60, a human intestinal anaerobic bacterium. Biosci Biotechnol Biochem. 65: 1163-9 (2001) https://doi.org/10.1271/bbb.65.1163 - Konno C, Sugiyama K, Kano M, Takahashi M, Hikino H. Isolation and hypoglycaemic activity of panaxans A, B, C, D and E, glycans of Panax ginseng roots. Planta Med. 50: 434-6 (1984) https://doi.org/10.1055/s-2007-969757
- Ng TB, Yeung HW. Hypoglycemic constituents of Panax ginseng. Gen Pharmacol. 16: 549-52 (1985) https://doi.org/10.1016/0306-3623(85)90140-5
- Tomoda M, Takeda K, Shimizu N, Gonda R, Ohara N, Takada K, Hirabayashi K. Characterization of two acidic polysaccharides having immunological activities from the root of Panax ginseng. Biol Pharm Bull. 16: 22-5 (1993) https://doi.org/10.1248/bpb.16.22
- Lee SJ, Sung JH, Lee SJ, Moon CK, Lee BH. Antitumor activity of a novel ginseng saponin metabolite in human pulmonary adenocarcinoma cells resistant to cisplatin. Cancer Lett. 144: 39-43 (1999) https://doi.org/10.1016/S0304-3835(99)00188-3
- Kang KA, Kim YW, Kim SU, Chae S, Koh YS, Kim HS, Choo MK, Kim DH, Hyun JW. G1 phase arrest of the cell cycle by a ginseng metabolite, compound K, in U937 human monocytic leukamia cells. Arch Pharm Res. 28: 685-90 (2005) https://doi.org/10.1007/BF02969359
- Kang J, Lee Y, No K, Jung E, Sung J, Kim Y, Nam S. Ginseng intestinal metabolite-I (GIM-I) reduces doxorubicin toxicity in the mouse testis. Reprod Toxicol. 16: 291-8 (2002) https://doi.org/10.1016/S0890-6238(02)00021-7
- Choi K, Kim M, Ryu J, Choi C. Ginsenosides compound K and Rh(2) inhibit tumor necrosis factor-alpha-induced activation of the NF-kappaB and JNK pathways in human astroglial cells. Neurosci Lett. 421: 37-41 (2007) https://doi.org/10.1016/j.neulet.2007.05.017
- Jung SH, Woo MS, Kim SY, Kim WK, Hyun JW, Kim EJ, Kim DH, Kim HS. Ginseng saponin metabolite suppresses phorbol ester-induced matrix metalloproteinase-9 expression through inhibition of activator protein-1 and mitogen-activated protein kinase signaling pathways in human astroglioma cells. Int J Cancer. 118: 490-7 (2006) https://doi.org/10.1002/ijc.21356
-
Park EK, Shin YW, Lee HU, Kim SS, Lee YC, Lee BY, Kim DH. Inhibitory effect of ginsenoside
$\text Rb_1$ and compound K on NO and prostaglandin E2 biosyntheses of RAW264.7 cells induced by lipopolysaccharide. Biol Pharm Bull. 28: 652-6 (2005) https://doi.org/10.1248/bpb.28.652 - Bae EA, Choo MK, Park EK, Park SY, Shin HY, Kim DH. Metabolism of ginsenoside R(c) by human intestinal bacteria and its related antiallergic activity. Biol Pharm Bull. 25: 743-7 (2002) https://doi.org/10.1248/bpb.25.743
-
Shin YW, Kim DH. Antipruritic effect of ginsenoside
$\text Rb_1$ and compound k in scratching behavior mouse models. J Pharmacol Sci. 99: 83-8 (2005) https://doi.org/10.1254/jphs.FP0050260 - Cai BX, Luo D, Lin XF, Gao J. Compound K suppresses ultraviolet radiation-induced apoptosis by inducing DNA repair in human keratinocytes. Arch Pharm Res. 31: 1483-8 (2008) https://doi.org/10.1007/s12272-001-2134-x
- Kim S, Kang BY, Cho SY, Sung DS, Chang HK, Yeom MH, Kim DH, Sim YC, Lee YS. Compound K induces expression of hyaluronan synthase 2 gene in transformed human keratinocytes and increases hyaluronan in hairless mouse skin. Biochem Biophys Res. Commun. 316: 348-55 (2004) https://doi.org/10.1016/j.bbrc.2004.02.046
- Yang CS, Ko SR, Cho BG, Shin DM, Yuk JM, Li S, Kim JM, Evans RM, Jung JS, Song DK, Jo EK. The ginsenoside metabolite compound K, a novel agonist of glucocorticoid receptor, induces tolerance to endotoxin-induced lethal shock. J Cell Mol Med. 12: 1739-53 (2008) https://doi.org/10.1111/j.1582-4934.2007.00181.x
-
Lee HU, Bae EA, Han MJ, Kim NJ, Kim DH. Hepatoprotective effect of ginsenoside
$\text Rb_1$ and compound K on tert-butyl hydroperoxide-induced liver injury. Liver Int. 25: 1069-73 (2005) https://doi.org/10.1111/j.1478-3231.2005.01068.x - Chang TC, Huang SF, Yang TC, Chan FN, Lin HC, Chang WL. Effect of ginsenosides on glucose uptake in human Caco-2 cells is mediated through altered Na+/glucose cotransporter 1 expression. J Agric Food Chem. 55: 1993-8 (2007) https://doi.org/10.1021/jf062714k
- Han GC, Ko SK, Sung JH, Chung SH. Compound K enhances insulin secretion with beneficial metabolic effects in db/db mice. J Agric Food Chem. 55: 10641-8 (2007) https://doi.org/10.1021/jf0722598
- Yoon SH, Han EJ, Sung JH, Chung SH. Anti-diabetic effects of compound K versus metformin versus compound K-metformin combination therapy in diabetic db/db mice. Biol. Pharm Bull. 30: 2196-200 (2007) https://doi.org/10.1248/bpb.30.2196
- Kim DH, Jung JS, Moon YS, Sung JH, Suh HW, Kim YH, Song DK. Inhibition of intracerebroventricular injection stressinduced plasma corticosterone levels by intracerebroventricularly administered compound K, a ginseng saponin metabolite, in mice. Biol Pharm Bull. 26: 1035-8 (2003) https://doi.org/10.1248/bpb.26.1035
- Trinh HT, Han SJ, Kim SW, Lee YC, Kim DH. Bifidus fermentation increases hypolipidemic and hypoglycemic effects of red ginseng. J Microbiol Biotechnol. 17: 1127-33 (2007)
-
Lai DM, Tu YK, Liu IM, Chen PF, Cheng JT. Mediation of beta-endorphin by ginsenoside
$\text Rh_2$ to lower plasma glucose in streptozotocin-induced diabetic rats. Planta Med. 72: 9-13 (2006) https://doi.org/10.1055/s-2005-916177 -
Niu CS, Yeh CH, Yeh MF, Cheng JT. Increase of adipogenesis by ginsenoside (
$\text Rh_2$ ) in 3T3-L1 cell via an activation of glucocorticoid receptor. Horm Metab Res. 41: 271-6 (2009) https://doi.org/10.1055/s-0028-1103277 -
Hwang JT, Kim SH, Lee MS, Kim SH, Yang HJ, Kim MJ, Kim HS, Ha J, Kim MS, Kwon DY. Anti-obesity effects of ginsenoside
$\text Rh_2$ are associated with the activation of AMPK signaling pathway in 3T3-L1 adipocyte. Biochem Biophys Res Commun. 364: 1002-8 (2007) https://doi.org/10.1016/j.bbrc.2007.10.125 -
Lee WK, Kao ST, Liu IM, Cheng JT. Ginsenoside
$\text Rh_2$ is one of the active principles of Panax ginseng root to improve insulin sensitivity in fructose-rich chow-fed rats. Horm Metab Res. 39: 347-54 (2007) https://doi.org/10.1055/s-2007-976537 - Huang J, Tang XH, Ikejima T, Sun XJ, Wang XB, Xi RG, Wu LJ. A new triterpenoid from Panax ginseng exhibits cytotoxicity through p53 and the caspase signaling pathway in the HepG2 cell line. Arch Pharm Res. 31: 323-9 (2008) https://doi.org/10.1007/s12272-001-1159-8
-
Kim YS, Jin SH, Lee YH, Kim SI, Park JD. Ginsenoside
$\text Rh_2$ induces apoptosis independently of Bcl-2, Bcl-xL, or Bax in C6Bu-1 cells. Arch Pharm Res. 22: 448-53 (1999) https://doi.org/10.1007/BF02979151 -
Oh JI, Chun KH, Joo SH, Oh YT, Lee SK. Caspase-3-dependent protein kinase C delta activity is required for the progression of Ginsenoside-
$\text Rh_2$ -induced apoptosis in SK-HEP-1 cells. Cancer Lett. 230: 228-38 (2005) https://doi.org/10.1016/j.canlet.2004.12.043 -
Ham YM, Lim JH, Na HK, Choi JS, Park BD, Yim H, Lee SK. Ginsenoside-
$\text Rh_2$ -induced mitochondrial depolarization and apoptosis are associated with reactive oxygen speciesand Ca2+-mediated c-Jun NH2-terminal kinase 1 activation in HeLa cells. J Pharmacol Exp Ther. 319: 1276-85 (2006) https://doi.org/10.1124/jpet.106.109926 -
Kim SY, Kim DH, Han SJ, Hyun JW, Kim HS. Repression of matrix metalloproteinase gene expression by ginsenoside
$\text Rh_2$ in human astroglioma cells. Biochem Pharmacol. 74: 1642-51 (2007) https://doi.org/10.1016/j.bcp.2007.08.015 -
Kim HS, Lee EH, Ko SR, Choi KJ, Park JH, Im DS. Effects of ginsenosides
$\text Rg_3$ and$\text Rh_2$ on the proliferation of prostate cancer cells. Arch Pharm Res. 27: 429-35 (2004) https://doi.org/10.1007/BF02980085 -
Fei XF, Wang BX, Tashiro S, Li TJ, Ma JS, Ikejima T. Apoptotic effects of ginsenoside
$\text Rh_2$ on human malignant melanoma A375-S2 cells. Acta Pharmacol Sin. 2002: 23: 315-22 -
Xie X, Eberding A, Madera C, Fazli L, Jia W, Goldenberg L, Gleave M, Guns ES.
$\text Rh_2$ synergistically enhances paclitaxel or mitoxantrone in prostate cancer models. J Urol 175: 1926-31 (2006) https://doi.org/10.1016/S0022-5347(05)00891-8 -
Jia WW, Bu X, Philips D, Yan H, Liu G, Chen X, Bush JA, Li G.
$\text Rh_2$ , a compound extracted from ginseng, hypersensitizes multidrug-resistant tumor cells to chemotherapy. Can J Physiol Pharmacol. 82: 431-7 (2004) https://doi.org/10.1139/y04-049 - Bae EA, Hyun YJ, Choo MK, Oh JK, Ryu JH, Kim DH. Protective effect of fermented red ginseng on a transient focal ischemic rats. Arch Pharm Res. 27: 1136-40 (2004) https://doi.org/10.1007/BF02975119
-
Lee E, Kim S, Chung KC, Choo MK, Kim DH, Nam G, Rhim H. 20(S)-ginsenoside
$\text Rh_2$ , a newly identified active ingredient of ginseng, inhibits NMDA receptors in cultured rat hippocampal neurons. Eur J Pharmacol. 536: 69-77 (2006) https://doi.org/10.1016/j.ejphar.2006.02.038 -
Park EK, Choo MK, Kim EJ, Han MJ,. Antiallergic activity of ginsenoside
$\text Rh_2$ . Biol Pharm Bull. 26: 1581-4 (2003) https://doi.org/10.1248/bpb.26.1581 -
Bae EA, Han MJ, Shin YW, Kim DH. Inhibitory effects of Korean red ginseng and its genuine constituents ginsenosides
$\text Rg_3$ , Rf, and$\text Rh_2$ in mouse passive cutaneous anaphylaxis reaction and contact dermatitis models. Biol Pharm Bull. 29: 1862-7 (2006) https://doi.org/10.1248/bpb.29.1862 -
Park YC, Lee CH, Kang HS, Kim KW, Chung HT, Kim HD. Ginsenoside-
$\text Rh_1$ and$\text Rh_2$ inhibit the induction of nitric oxide synthesis in murine peritoneal macrophages. Biochem Mol Biol Int. 40: 751-7 (1996) -
Bae EA, Kim EJ, Park JS, Kim HS, Ryu JH, Kim DH. Ginsenosides
$\text Rg_3$ and$\text Rh_2$ inhibit the activation of AP-1 and protein kinase A pathway in lipopolysaccharide/interferongamma- stimulated BV-2 microglial cells. Planta Med. 72: 627-33 (2006) https://doi.org/10.1055/s-2006-931563 -
Lee HU, Bae EA, Han MJ, Kim DH. Hepatoprotective effect of 20(S)-ginsenosides
$\text Rg_3$ and its metabolite 20(S)- ginsenoside$\text Rh_2$ on tert-butyl hydroperoxide-induced liver injury. Biol. Pharm. Bull. 28: 1992-4 (2005) https://doi.org/10.1248/bpb.28.1992 - Wang Z, Zheng Q, Liu K, Li G, Zheng R. Ginsenoside Rh(2) enhances antitumour activity and decreases genotoxic effect of cyclophosphamide. Basic Clin. Pharmacol. Toxicol. 98: 411-5 (2006) https://doi.org/10.1111/j.1742-7843.2006.pto_348.x
-
Park EK, Choo MK, Han MJ, Kim DH. Ginsenoside
$\text Rh_1$ possesses antiallergic and anti-inflammatory activities. Int Arch Allergy Immunol. 133: 113-20 (2004) https://doi.org/10.1159/000076383 -
Shin YW, Bae EA, Kim SS, Lee YC, Lee BY, Kim DH. The effects of ginsenoside Re and its metabolite, ginsenoside
$\text Rh_1$ , on 12-O-tetradecanoylphorbol 13-acetate- and oxazolone-induced mouse dermatitis models. Planta Med. 72: 376-8 (2006) https://doi.org/10.1055/s-2005-916217 - Byun BH, Shin I, Yoon YS, Kim SI, Joe CO. Modulation of protein kinase C activity in NIH 3T3 cells by plant glycosides from Panax ginseng. Planta Med. 63: 389-92 (1997) https://doi.org/10.1055/s-2006-957719
- Yun TK, Lee YS, Lee YH, Kim SI, Yun HY. Anticarcino genic effect of Panax ginseng C.A. Meyer and identification of active compounds. J. Korean Med Sci. 16 Suppl: S6-18 (2001) https://doi.org/10.3346/jkms.2001.16.S.S6
-
Kim YS, Kim DS, Kim SI. Ginsenoside
$\text Rh_2$ and$\text Rh_3$ induce differentiation of HL-60 cells into granulocytes: modulation of protein kinase C isoforms during differentiation by ginsenoside$\text Rh_2$ . Int J Biochem Cell Biol. 30: 327-38 (1998) https://doi.org/10.1016/S1357-2725(97)00141-6 - Bae EA, Shin JE, Kim DH. Metabolism of ginsenoside Re by human intestinal microflora and its estrogenic effect. Biol Pharm Bull. 28: 1903-8 (2005) https://doi.org/10.1248/bpb.28.1903
-
Lee Y, Jin Y, Lim W, Ji S, Choi S, Jang S, Lee S. A ginsenoside-
$\text Rh_1$ , a component of ginseng saponin, activates estrogen receptor in human breast carcinoma MCF-7 cells. J Steroid Biochem Mol. Biol. 84: 463-8 (2003) https://doi.org/10.1016/S0960-0760(03)00067-0 - Masuno H, Kitao T, Okuda H. Ginsenosides increase secretion of lipoprotein lipase by 3T3-L1 adipocytes. Biosci Biotechnol Biochem. 60: 1962-5 (1996) https://doi.org/10.1271/bbb.60.1962
-
Wang YZ, Chen J, Chu SF, Wang YS, Wang XY, Chen NH, Zhang JT.Improvement of memory in mice and increase of hippocampal excitability in rats by ginsenoside Rg1's metabolites ginsenoside
$\text Rh_1$ and protopanaxatriol. J Pharmacol Sci. 109: 504-10 (2009) https://doi.org/10.1254/jphs.08060FP -
Liu Y, Ma H, Zhang JW, Deng MC, Yang L. Influence of ginsenoside
$\text Rh_1$ and F1 on human cytochrome p450 enzymes. Planta Med. 72: 126-31 (2006) https://doi.org/10.1055/s-2005-873197 - Leung KW, Leung FP, Mak NK, Tombran-Tink J, Huang Y, Wong RN. Protopanaxadiol and protopanaxatriol bind to glucocorticoid and oestrogen receptors in endothelial cells. Br J Pharmacol. 156: 626-37 (2009) https://doi.org/10.1111/j.1476-5381.2008.00066.x
- Sun J, Hu S, Song X. Adjuvant effects of protopanaxadiol and protopanaxatriol saponins from ginseng roots on the immune responses to ovalbumin in mice. Vaccine. 25: 1114-20 (2007) https://doi.org/10.1016/j.vaccine.2006.09.054
- Han KL, Jung MH, Sohn JH, Hwang JK. Ginsenoside 20Sprotopanaxatriol (PPT) activates peroxisome proliferatoractivated receptor gamma (PPARgamma) in 3T3-L1 adipocytes. Biol Pharm Bull. 29: 110-3 (2006) https://doi.org/10.1248/bpb.29.110
- Oh GS, Pae HO, Choi BM, Seo EA, Kim DH, Shin MK, Kim JD, Kim JB, Chung HT. 20(S)-Protopanaxatriol, one of ginsenoside metabolites, inhibits inducible nitric oxide synthase and cyclooxygenase-2 expressions through inactivation of nuclear factor-kappaB in RAW 264.7 macrophages stimulated with lipopolysaccharide. Cancer Lett. 205: 23-9 (2004) https://doi.org/10.1016/j.canlet.2003.09.037
- Usami Y, Liu YN, Lin AS, Shibano M, Akiyama T, Itokawa H, Morris-Natschke SL, Bastow K, Kasai R, Lee KH. Antitumor agents. 261. 20(S)-protopanaxadiol and 20(s)-protopanaxatriol as antiangiogenic agents and total assignment of (1)H NMR spectra. J Nat Prod. 71: 478-81 (2008) https://doi.org/10.1021/np070613q
- Wang M, Guilbert LJ, Ling L, Li J, Wu Y, Xu S, Pang P, Shan JJ. Immunomodulating activity of CVT-E002, a proprietary extract from North American ginseng (Panax quinquefolium). J Pharm Pharmacol. 53: 1515-23 (2001) https://doi.org/10.1211/0022357011777882
- Tomoda M, Hirabayashi K, Shimizu N, Gonda R, Ohara N. The core structure of ginsenan PA, a phagocytosis-activating polysaccharide from the root of Panax ginseng. Biol Pharm Bull. 17: 1287-91 (1994) https://doi.org/10.1248/bpb.17.1287
- Tomoda M, Takeda K, Shimizu N, Gonda R, Ohara N, Takada K, Hirabayashi K. Characterization of two acidic polysaccharides having immunological activities from the root of Panax ginseng. Biol Pharm Bull 16: 22-25 (1993) https://doi.org/10.1248/bpb.16.22
- Jie YH, Cammisuli S, Baggiolini M. Immunomodulatory effects of Panax ginseng C. A. Meyer in the mouse. Agents Actions. 15: 386-91 (1984) https://doi.org/10.1007/BF01972376
- Gao H, Wang F, Lien EJ, Trousdale MD. Immunostimulating polysaccharides from Panax notoginseng. Pharm Res 13: 1196-200 (1996) https://doi.org/10.1023/A:1016060119425
- Hu S, Concha C, Cooray R, Holmberg O. Ginseng enhanced oxidative and phagocytic activities of polymorphonuclear leucocytes from bovine peripheral blood and stripping milk. Vet Res. 26: 155-61 (1995)
- Scaglione F, Ferrara F, Dugnani S, Falchi M, Santoro G, Fraschini F. Immunomodulatory effects of two extracts of Panax ginseng C. A. Meyer. Drugs Exp Clin Res. 16: 537-42 (1990)
- Kim JY, Germolec DR, Luster MI. Panax ginseng as a potential immunomodulator: studies in mice. Immunopharmacol Immunotoxicol. 12: 257-76 (1990) https://doi.org/10.3109/08923979009019672
- Sun XB, Matsumoto T, Kiyohara H, Hirano M, Yamada H. Cytoprotective activity of pectic polysaccharides from the root of panax [sic] ginseng. J Ethnopharmacol. 31: 101-07 (1991) https://doi.org/10.1016/0378-8741(91)90148-7
- Kim KH, Lee YS, Jung IS, Park SY, Chung HY, Lee IR, Yun YS. Acidic polysaccharide from Panax ginseng, ginsan, induces Th1 cell and macrophage cytokines and generates LAK cells in synergy with rIL-2. Planta Med. 64: 110-15 (1998) https://doi.org/10.1055/s-2006-957385
- Lim DS, Bae KG, Jung IS, Kim CH, Yun YS, Song JY. Related Articles, Links Anti-septicaemic effect of polysaccharide from Panax ginseng by macrophage activation. J Infet. 45: 32-38 (2002) https://doi.org/10.1053/jinf.2002.1007
- Ahn JY, Choi IS, Shim JY, Yun EK, Yun YS, Jeong G, Song JY. The immunomodulator ginsan induces resistance to experimental sepsis by inhibiting Toll-like receptor-mediated inflammatory signals. Eur J Immunol. 36: 37-45 (2006) https://doi.org/10.1002/eji.200535138
- Shin HJ, Kim YS, Kwak YS, Song YB, Kim YS, Park JD. Enhancement of antitumor effects of paclitaxel (taxol) in combination with red ginseng acidic polysaccharide (RGAP). Planta Med. 70: 1033-38 (2004) https://doi.org/10.1055/s-2004-832643
- Trinh HT, Han SJ, Kim SW, Lee YC, Kim DH. Bifidus fermentation increases hypolipidemic and hypoglycemic effects of red ginseng. J Microbiol Biotechnol. 17: 1127-33 (2007)
- Bae EA, Kim NY, Han MJ, Choo MK, Kim DH. Transformation of ginsenosides to compound K by lactic acid bacteria of human intestine. J Microbiol Biotechnol. 13: 9-14 (2003)
- Kitaoka K, Uchida K, Okamoto N, Chikahisa S, Miyazaki T, Takeda E, Séi H. Fermented ginseng improves the firstnight effect in humans. Sleep. 32: 413-21 (2009) https://doi.org/10.1093/sleep/32.3.413
-
Dong A, Ye M, Guo H, Zheng J, Guo D. Microbial transformation of ginsenoside
$\text Rb_1$ by Rhizopus stolonifer and Curvularia lunata. Biotechnol Lett. 25: 339-44 (2003) https://doi.org/10.1023/A:1022320824000 - Han Y, Sun B, Hu X, Zhang H, Jiang B, Spranger MI, Zhao Y. Transformation of bioactive compounds by Fusarium sacchari fungus isolated from the soil-cultivated ginseng. J Agric Food Chem. 55: 9373-9 (2007) https://doi.org/10.1021/jf070354a
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