Overview of Diabetic Peripheral Neuropathy and Need for Therapeutic Strategy using Traditional Korean Medicine

당뇨병성 말초 신경병증의 개괄과 한의학적 연구의 필요성

  • Kim, Jin-Mi (Internal Department of Oriental Medicine College, Daejeon University) ;
  • Youn, Sung-Sik (Internal Department of Oriental Medicine College, Daejeon University) ;
  • An, So-Hyun (Internal Department of Oriental Medicine College, Daejeon University) ;
  • Choi, Jeong-Sik (Internal Department of Oriental Medicine College, Daejeon University) ;
  • Cho, Chung-Sik (Internal Department of Oriental Medicine College, Daejeon University) ;
  • Son, Chang-Gue (Internal Department of Oriental Medicine College, Daejeon University) ;
  • Kim, Chul-Jung (Internal Department of Oriental Medicine College, Daejeon University)
  • 김진미 (대전대학교 한의과대학 신계내과학교실) ;
  • 윤성식 (대전대학교 한의과대학 신계내과학교실) ;
  • 안소현 (대전대학교 한의과대학 신계내과학교실) ;
  • 최정식 (대전대학교 한의과대학 신계내과학교실) ;
  • 조충식 (대전대학교 한의과대학 신계내과학교실) ;
  • 손창규 (대전대학교 한의과대학 간장면역학교실) ;
  • 김철중 (대전대학교 한의과대학 신계내과학교실)
  • Published : 2009.09.30

Abstract

Objective: This study aimed to analyze the current status of treatments and patients with diabetic peripheral neuropathy, and then map out of a strategy for development of generalized-treatments for diabetic peripheral neuropathy in Traditional Korean Medicine. Methods: We selected research materials from various databases such as PubMed, Google, KStudy, KoreanTK, OIM, KOMS and books. Also, to understand current tendencies of medical examination and treatment related with diabetic peripheral neuropathy, we requested Health Insurance Review and Assessment Service clinical data from 2003 to 2007. Results: It is reported that the incidence of diabetic peripheral neuropathy is increasing in an aging society. The medical fees of National Health Insurance related with diabetic peripheral neuropathy show a year-on-year increase. There are no particularly effective therapies for diabetic peripheral neuropathy in Western medicine, and in some papers, it was reported that treatment of diabetic peripheral neuropathy using Traditional Korean Medicine was effective. However, patients usually visit on Western medical center rather than seek Traditional Korean Medicine. To take charge of clinical fields related with diabetic peripheral neuropathy by Traditional Korean Medicine, we need more studies and experiments of diabetic peripheral neuropathy using Traditional Korean Medicine and should make a standardized protocol. Conclusion: Various studies related with diabetic peripheral neuropathy using Traditional Korean Medicine will have to be undertaken hereafter. We expect that Traditional Korean Medicine will play a vital role in treating of diabetic peripheral neuropathy.

Keywords

References

  1. Shaw JE, Zimmet PZ. The epidemiology of diabetic neuropathy. Diabetes Rev 1999;7:245-52.
  2. Ziegler D, Rathmann W, Haastert B, Fuchsle-Reiter A, Lowel H, Mielck A. Prevalence of polyneuropathy in impaired glucose tolerance and diabetes. The MONICA/KORA Augsburg Surveys and Myocardial Infarction Registry(KORA-A Study). Diabetologia. 2005;48(suppl 1):A364-5.
  3. Herman WH, Kennedy L. Underdiagnosis of peripheral neuropathy in type 2 diabetes. Diabetes Care. 2005;28:1480-1. https://doi.org/10.2337/diacare.28.6.1480
  4. Daousi C, MacFarlane IA, Woodward A, Nurmikko TJ, Bundred PE, Benbow SJ. Chronic painful peripheral neuropathy in an urban community: a controlled comparison of people with and without diabetes. Diabet Med. 2004;21:976-82. https://doi.org/10.1111/j.1464-5491.2004.01271.x
  5. A society for the research of Neuropathy in Korean Diabetes Association. Clinical practice of diabetic neuropathy. 2nd ed. Seoul:Korean Diabetes Association. 2007:1-48.
  6. Boulton AJ, Malik RA, Arezzo JC, Sosenko JM. Diabetic somatic neuropathies. Diabetes Care. 2004;27:1458-86. https://doi.org/10.2337/diacare.27.6.1458
  7. Boulton AJM. Management of diabetic peripheral neuropathy. Clin Diabetes. 2005;23:9-15. https://doi.org/10.2337/diaclin.23.1.9
  8. Cho JH, Ahn SK, Kim SM, Lee WT, Park KA. The Effects of Soybean Diet on the Diabetic Neuropathy in the Rats. The Korean J. Anat. 2006;39(6):433-41.
  9. Kang SB. 2 case of Diabetic Neuropathy Treatments. J Korean Oriental Med. 1992;13(2):22-5.
  10. Park SW, Kang JK, Moon SK, Ko CN. Two experiences of the treatment for diabetic peripheral neuropathy. The Journal of Korean Oriental Chronic Disease. 1997;3(1):251-8.
  11. Cho KH, Jung S, Lee KJ. A Case of Yukmijihwanghwan’s effect on Diabetic neuropathy. Korean J. Orient. Int. Med. 1999;20(1):286-90.
  12. Kwon YK, Choi KR, Lee JS, Lee BC, Ahn YM, Ahn SY, et al. Two Cases of Diabetic Peripheral Polyneuropathy Improved by Bogan-tang. J Korean Oriental Med. 2002;23(1):170-7.
  13. Park SK, Kwon EH, Shin HC, Kang SB. One Case of Diabetic Peripheral Polyneuropathy Improved by Binsosan-gamibang. J Korean Oriental Med. 2005:26(4):935-40.
  14. Choi HS, Cho CS, Kim CJ. Clinical Study on Two Cases of In patients with Diabetic Peripheral Neuropathy. Daejeon University Institute of korean medicine thesis Collection. 2004;13(2):251-8.
  15. Park KD, Lee SC, Park YG, Moon JH, Lim SH. Sympathetic Skin Response at Big toe in Diabetic polyneuropathy. Journal of the Korean Association EMG-Electrodiagnostic Medicine. 2006;8(1):1-6.
  16. Pirat J. Diabetes mellitus and its degenerative complications: a prospective study of 4,400 patients observed between 1947 and 1973. Diabetes care. 1978;1:168-252.
  17. Bruyn GW, Garland H. Neuropathies of endocrine origin. In: Vinken PJ, Bruyn GW, editors. Handbook of clinical neurology. 8th ed. Amsterdam:North Holland Publishing Co. 1970:29.
  18. Kastenbauer T, Irsigler P, Sauseng S, Grimm A, Prager R. The prevalence of symptoms of sensorimotor and autonomic neuropathy in type 1 and type 2 diabetic subjects. J Diabetes Complications. 2004;18:27-31. https://doi.org/10.1016/S1056-8727(03)00071-0
  19. Partanen J, Niskanen L, Lehtinen J, Mervaala E, Siitonen O, Uusitupa M. Natural history of peripheral neuropathy in patients with non-insulindependent diabetes mellitus. N Engl J Med. 1995;333:89-94. https://doi.org/10.1056/NEJM199507133330203
  20. Lehtinen JM, Uusitupa M, Siitonen O, Pyorala K. Prevalence of neuropathy in newly diagnosed NIDDM and nondiabetic control subjects. Diabetes. 1989;38:1307-13. https://doi.org/10.2337/diabetes.38.10.1307
  21. Faes TJC, Yff GA, DeWeerrdt O, Lanting P, Heimans JJ. Treatment of diabetic autonomic neuropathy with an aldose reductase inhibitor. J Neurol. 1993;240:156-60. https://doi.org/10.1007/BF00857521
  22. Boland OM, Blackwell CC, Clake BF, Ewing DJ. Effects of ponalrestat, an aldose reductase inhibitor, on neutrophil kiling of Escherichia coli and autonomic fuction in patients with diabetes mellitus. Diabetes. 1993;42:336-40. https://doi.org/10.2337/diabetes.42.2.336
  23. Giuglino D, Acampora R, Mafella R, Quatraro A. Tolestat for mild diabetic neuropathy:a 52-week, randomized, placebo controlled trial. Ann Intern Med. 1993;118:7-11. https://doi.org/10.7326/0003-4819-118-1-199301010-00002
  24. Low PA, Nickander KK. Oxygen free radical effects in sciatic nerve in experimental diabetes. Diabetes. 1991;40:873-7. https://doi.org/10.2337/diabetes.40.7.873
  25. Nickander KK, Schmelzer JD, Rohwer DA, Low PA. Effect of $\alpha$-tocoperol deficiency on indices of oxidative stress in normal and diabetic peripheral nerve. J Neurol Sci. 1994;126:6-14. https://doi.org/10.1016/0022-510X(94)90088-4
  26. Cameron NE, Cotter MA. The relationship of vascular change to metabolic factors in diabetes mellitus and their role in the development of peripheral nerve complication. Diab Metab Rev. 1994;10:189-224. https://doi.org/10.1002/dmr.5610100302
  27. Green DA, Stevens MJ, Obrosova I, Feldman EL. Glucose-induced oxidative stress and programmed cell death in diabetic neuropathy. Eur J Pharmacol 375. 1999;217-23. https://doi.org/10.1016/S0014-2999(99)00356-8
  28. Sima AA. New insights into the metabolic and molecular basis for diabetic neuropathy. Cell Mol Life Sci 60. 2003;2445-64. https://doi.org/10.1007/s00018-003-3084-x
  29. Doo HK. Internal medicine of kidney in oriental medicine. Seoul:Institute of oriental medicine. 1991:969-76.
  30. Sima AAF, Cherian PV. Neuropathology of diabetic neuropathy and its correlations with neurophyiology. Clin Neurosci. 1997;4:359-64.
  31. Kwon SB, Kwon KH, Jung S, Oh MS, Hwang SH. Electrophysiological Evidence of Demyelination in Patients with Diabetic Neuropathy. J Korean Neurol Assoc. 2004;22(3):240-8.
  32. Braunwald E, Fauci AS, Kasper DS, Hauser SL, Longo DL, Jameson J. Harrison’s Principles of Internal Medicine. 15th ed. Korean:MIP. 2003:2192.
  33. Diabetes. Available at: URL:http://www.hira.or. kr/common/dummy.jsp?pgmid=HIRAA021100000000. Accessed July 16, 2009.