Food Science and Biotechnology

Korean Society of Food Science and Technology (한국식품과학회)
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Perilla Leaf Extract Inhibits 3T3-L1 Preadipocytes Differentiation

  • Kim, Mi-Ja (Department of Food and Nutrition, Dongduk Women's University) ;
  • Kim, Hye-Kyung (Department of Food and Biotechnology, Hanseo University)
  • Published : 2009.08.31
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Abstract

Effects of perilla leaf extracts (PLE) on adipocytes differentiation of 3T3-L1 cells were examined. Ethanol extract of PLE treatment significantly decreased lipid accumulation, a marker of adipogenesis, in a dose-dependent manner. Moreover, gene expression levels of peroxisome proliferator-activated receptor ${\gamma}$ ($PPAR{\gamma}$), the key adipogenic transcription factor, were markedly decreased by PLE. PLE also suppressed adipocyte fatty acid binding protein (aP2) and glycerol-3-phosphate dehydrogenase (GPDH), which are adipogenic marker proteins. These results suggest that PLE treatment suppressed differentiation of 3T3-L1 adipocytes, in part by down-regulating expression of adipogenic transcription factor and other specific target genes.

Keywords

References

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