Journal of Preventive Medicine and Public Health

The Korean Society for Preventive Medicine (대한예방의학회)
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Blood Mercury Concentration and Related Factors in an Urban Coastal Area in Korea

  • Jo, Eun-Mi (Department of Preventive Medicine, College of Medicine, Dong-A University) ;
  • Kim, Byoung-Gwon (Department of Preventive Medicine, College of Medicine, Dong-A University) ;
  • Kim, Yu-Mi (Department of Preventive Medicine, College of Medicine, Dong-A University) ;
  • Yu, Seung-Do (Health Risk Research Department, Environmental Epidemiology Division, National Institute of Environmental Research) ;
  • You, Chang-Hun (Department of Preventive Medicine, College of Medicine, Dong-A University) ;
  • Kim, Joon-Youn (Department of Preventive Medicine, College of Medicine, Dong-A University) ;
  • Hong, Young-Seoub (Department of Preventive Medicine, College of Medicine, Dong-A University)
  • Received : 2010.04.09
  • Accepted : 2010.06.29
  • Published : 2010.09.30
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Abstract

Objectives: This study was carried out for the purpose of evaluating the blood mercury concentration of the residents of Busan, Korea, as well as the relationship between the mercury concentration and the pattern of fish consumption along with other epidemiological factors. Methods: Two hundred ninety-three subjects (147 men and 146 women), who were aged 40 years or more, were recruited into this study between June and October 2009. The mean age of the subjects was 54.3 years (with a range of 40-70 years). Mercury concentrations in blood samples were measured using a gold-amalgam collection method. Results: The geometric mean concentration of mercury in the total subjects was $8.63\;{\mu}g/L$ [range: $1.48{\sim}45.71\;{\mu}g/L$]. The blood mercury concentration of the men ($9.55\;{\mu}g/L$) was significantly higher than that of the women ($7.76\;{\mu}g/L$). The blood mercury concentration of those who eat fish more than 4 times per week was higher than others, and was statistically significant (male p = 0.0019, female p = 0.0002). According to the multiple analysis, the blood mercury concentration was significantly affected by the consumed fish but other epidemiological factors were not related. Conclusions: It was found that the subjects who have consumed a large amount of fish may have high blood mercury concentration. It appears that fish consumption can influence blood mercury concentration. Therefore, guidelines for fish consumption that will decrease blood mercury concentration might be necessary in Korea.

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References

  1. Navarro M, Lopez H, Sanchez M, Lopez MC. The effect of industrial pollution on mercury levels in water, soil and sludge in the coastal area of Montril, southeast Spain. Arch Environ Contam Toxicol 1993; 24(1): 11-15 https://doi.org/10.1007/BF01061083
  2. WHO. Environmental Health Criteria 1 : Mercury. Geneva: World Health Organization; 1976, p. 94-131.
  3. Harada M. Minamata disease: methylmercury poisoning in Japan caused by environmental pollution. Crit Rev Toxicol 1995; 25(1): 1-24. https://doi.org/10.3109/10408449509089885
  4. Kim YS, Lee EJ, Bae SH, Ohtsuka R, Suzuki T. Mercury concentrations in pregnant women's hair in the Seoul area. Korean J Environ Health 1992; 18(1): 105-111. (Korean)
  5. Magos L, Clarkson TW, Sparrow S, Hudson AR. Comparison of the protection given by selenite, selenomethionine and biological selenium against the renotoxicity of mercury. Arch Toxicol 1987; 60(6): 422-426. https://doi.org/10.1007/BF00302384
  6. Airey D. Total mercury concentration in human hair from 13 countries in relation to fish consumption and location. Sci Total Environ 1983; 31(2): 157-180. https://doi.org/10.1016/0048-9697(83)90067-0
  7. Apostoli P, Cortesi I, Mangili A, Elia G, Drago I, Gagliardi T, et al. Assessment of reference values for mercury in urine: the results of an Italian polycentric study. Sci Total Environ 2002; 289(1-3): 13-24. https://doi.org/10.1016/S0048-9697(01)01013-0
  8. WHO/IPCS. Methylmercury In Environmental Health Criteria 101. Geneva: World Health Organization; 1990.
  9. Park SB. The Relationship between Amalgam Use and The Concentration of Urine Mercury of Workers in Dental Hospitals[dissertation]. Daegu: Yeungnam University; 2009. (Korean)
  10. Park JT, Kim KJ, Bang SH. A follow up study on the mercury concentration in air and in urine of workers after implementing controls of work environment in mercury vapor exposed industry. J Korean Ind Hyg Assoc 1994; 4(2): 198-207. (Korean)
  11. Ministry of Environment. Survey of Blood Heavy Metal Concentration in Koreans. Seoul: Ministry of Environment; 2005. (Korean)
  12. National Institute of Environmental Research. Secondary Survey of in vivo Hazardous Materials Level in Koreans. Incheon: National Institute of Environmental Research; 2007, p. 157-170. (Korean)
  13. National Institute of Environmental Research. Tertiary Survey of in vivo Hazardous Materials Level in Koreans. Incheon: National Institute of Environmental Research; 2008, p. 240-246. (Korean)
  14. Ho Mk, Lim YW, Lim JH, Yang JY, Shin DC. Association between blood mercury concentration and factor of health/life. Korean J Environ Toxicol 2006; 21(3): 229-238. (Korean)
  15. Sakamoto M, Kaneoka T, Murata K, Nakai K, Satoh H, Akagi H. Correlations between mercury concentrations in umbilical cord tissue and other biomarkers of fetal exposure to methylmercury in the Japanese population. Environ Res 2007; 103(1): 106-111. https://doi.org/10.1016/j.envres.2006.03.004
  16. Mortada WI, Sobh MA, el-Defrawy MM, Farahat SE. Reference intervals of cadmium, lead, and mercury in blood, urine, hair, and nails among residents in Mansoura City, Nile delta, Egypt. Environ Res 2002; 90(2): 104-110. https://doi.org/10.1006/enrs.2002.4396
  17. Hsu CS, Liu PL, Chien LC, Chou SY, Han BC. Mercury concentration and fish consumption in Taiwanese pregnant women. BJOG 2007; 114(1): 81-85.
  18. Schober SE, Sinks TH, Jones RL, Bolger PM, McDowell M, Osterloh J, et al. Blood mercury levels in US children and women of childbearing age, 1999-2000. JAMA 2003; 289(13): 1667-1674. https://doi.org/10.1001/jama.289.13.1667
  19. Vupputuri S, Longnecker MP, Daniels JL, Guo X, Sandler DP. Blood mercury level and pressure among US women: results from the National Health and Nutrition Examination Survey 1999-2000. Environ Res 2005; 97(2): 195-200. https://doi.org/10.1016/j.envres.2004.05.001
  20. Cole DC, Wainman B, Sanin LH, Weber JP, Muggah H, Ibrahim S. Environmental contaminant levels and fecundability among non-smoking couples. Reprod Toxicol 2006; 22(1): 13-19. https://doi.org/10.1016/j.reprotox.2005.12.001
  21. Brune D, Nordberg GF, Vesterberg O, Gerhardsson L, Wester PO. A review of normal concentrations of mercury in human blood. Sci Total Environ 1991; 100: 235-282. https://doi.org/10.1016/0048-9697(91)90380-W
  22. Grandjean P, White RF, Weihe P, Jorgensen PJ. Neurotoxic risk caused by stable and variable exposure to methylmercury from seafood. Ambul Pediatr 2003; 3(1): 18-23. https://doi.org/10.1367/1539-4409(2003)003<0018:NRCBSA>2.0.CO;2
  23. Mahaffey KR, Mergler D. Blood levels of total and organic mercury in residents of the upper St. Lawrence River basin, Quebec: association with age, gender, and fish consumption. Environ Res 1988; 77(2): 104-114
  24. Wennberg M, Lundh T, Bergdahl IA, Hallmans G, Jansson JH, Stegmayr B, et al. Time trends in burdens of cadmium, lead, and mercury in the population of northern Sweden. Environ Res 2006; 100(3): 330-338. https://doi.org/10.1016/j.envres.2005.08.013
  25. Siblerud RL, Kienholz E, Motl J. Evidence that mercury from silver dental fillings may be an etiological factor in smoking. Toxicol Lett 1993; 68(3): 307-310. https://doi.org/10.1016/0378-4274(93)90022-P
  26. Kim NY. Effects of Life-style on the Blood Mercury Levels in Korean [dissertation]. Seoul: Chung-Ang University; 2009. (Korean)
  27. Urieta I, Jalon M, Eguilero I. Food surveillance in the Basque Country(Spain). II. Estimation of the dietary intake of organochlorine pesticides, heavy metals, arsenic, aflatoxin M1, iron and zinc through the Total Diet Study, 1990/91. Food Addit Contam 1996; 13(1): 29-52. https://doi.org/10.1080/02652039609374379
  28. Mahafffery KR, Clicker RP, Bodurow CC. Blood organic mercury and dietary mercury intake: National Health and Nutrition Examination Survey. 1999 and 2000. Environ Health Perspect 2004; 112(5): 562-570.
  29. Falter R, Scholer HF. Determination of methyl-, ethyl-, phenyl and total mercury in Neckar River fish. Chemosphere 1994; 29(6): 1333-1338. https://doi.org/10.1016/0045-6535(94)90263-1
  30. Morgan JN, Berry MR, Graves RL. Effects of commonly used cooking practises on total mercury concentration in fish and their impact on exposure assessments. J Expo Anal Environ Epidemiol 1997; 7(1): 119-133.
  31. Storelli MM, Stuffler RG, Marcotrigiano GO. Total and methylmercury residues in tuna-fish from the Mediterranean sea. Food Addit Contam 2002; 19(8): 715-720. https://doi.org/10.1080/02652030210153569
  32. Passos CJ, Mergler D, Lemire M, Fillion M, Guimaraes JR. Fish consumption and bioindicators of inorganic mercury exposure. Sci Total Environ 2007; 373(1): 68-76. https://doi.org/10.1016/j.scitotenv.2006.11.015
  33. Björnberg KA, Vahter M, Petersson-Grawe K, Glynn A, Cnattingius S, Darnerud PO, et al. Methyl mercury and inorganic mercury in swedish pregnant women and in cord blood: influence of fish consumption. Environ Health Perspect 2003; 111(4): 637-641. https://doi.org/10.1289/ehp.5618
  34. Mahaffey KR, Clickner RP, Bodurow CC. Blood organic mercury and dietary mercury intake: National Health and Nutrition Examination Survey, 1999 and 2000. Environ Health Perspect 2004; 112(5): 562-570.
  35. Yamamura Y, Yoshinaga Y, Arai F, Kishimoto T. Background levels of total mercury concentrations in blood and urine. Sangyo Igaku 1994; 36(2): 66-69. https://doi.org/10.1539/joh1959.36.2_66

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