Obstetrics & gynecology science

Korean Society of Obstetrics and Gynecology (대한산부인과학회)
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The relationship between serum leptin level and metabolic syndrome in postmenopausal women

폐경 후 여성에서 혈청 렙틴 농도와 대사증후군과의 관계

Lee, Suk-Woo;Cho, Hyun-Hee;Kim, Mee-Ran;Kwon, Dong-Jin;Kim, Eun-Jung;You, Young-Oak;Kim, Jang-Heup
이석우;조현희;김미란;권동진;김은중;유영옥;김장흡

  • Published : 20100300
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Abstract

Objective: Menopause status may lead to increases of body fat, abdominal obesity, and the incidence of metabolic syndrome (MS). Leptin is an adipokine that is secreted by adipocytes and plays an important role in regulating energy homeostasis and the reproductive system. This study examined the relationship among obesity, MS, and serum leptin levels in pre- and postmenopausal women. Methods: We divided 168 women who visited St. Vincent Hospital of the Catholic University of Korea in 2006 and 2007 into premenopausal vs. postmenopausal, obese vs. non-obese groups based on their body mass index (BMI) and the presence of MS. We measured serum follicle-stimulating hormone (FSH) level,serum estradiol level, BMI, the waist-hip ratio (WHR) and visceral fat area (VFA), serum fasting glucose, lipid profile, blood pressure, and serum leptin level. Results: Of 56 premenopausal and 112 postmenopausal women, there were 21 (37.5%) premenopausal and 51 (45.5%) postmenopausal women with MS. In the non-obese premenopausal and postmenopausal women, there were positive correlations between FSH, markers of abdominal obesity such as WHR and VFA, and serum leptin after adjusting for BMI in postmenopausal women. In the MS group, only WHR was correlated with the serum leptin level after adjusting for BMI in all groups. Conclusion: Increased serum FSH level and abdominal obesity lead to an increased serum leptin level in postmenopausal women. Further studies are needed to clarify the relationship between leptin and the metabolic syndrome, risk of cardiovascular disease in postmenopausal women.

목적: 폐경이 되면 체지방 및 복부비만의 증가 및 대사증후군의 유병률이 증가하며 심혈관계 질환의 빈도가 증가하는 것으로 보고되고 있다. 렙틴은 지방 세포에서 분비되는 호르몬으로 에너지 대사 조절, 여성 생식 기관 조절 등에 관여한다. 폐경 전후 여성에서 혈청 렙틴과 대사증후군과의 연관성에 대하여 연구를 시행하였다. 연구 방법: 2006년 1월부터 2007년 12월까지 가톨릭대학교 의과대학 성빈센트병원 산부인과를 방문한 폐경 전 여성 56명, 폐경 후 여성 112명을 대상으로 하였으며 각각의 그룹에서 혈청 렙틴, 복부비만도, 대사증후군 위험인자들을 비교하였고 혈청 난포자극호르몬, 에스트라디올 등의 여성 호르몬과 복부비만도, 대사증후군과 렙틴과의 관계를 상관분석, 회귀분석 및 ANCOVA를 이용하여 분석하였다. 결과: 전체 여성 중 대사증후군을 진단받은 여성은 각각 폐경 전에서 37.5%, 폐경 후에서 45.5%이었고, 폐경 후 여성에서 폐경 전보다 혈청 렙틴 농도와 체지방비율이 더 높았다. 체질량 지수를 보정하였을 때 비비만군에서 난포자극호르몬이 높을수록 혈청 렙틴의 농도가 증가하였으며, 폐경 후 여성에서 복부비만도를 나타내는 허리 엉덩이둘레비율 및 내장지방면적과 렙틴은 양의 상관관계를 보였다. 렙틴과 대사증후군 및 위험인자와의 비교에서는 복부비만만이 유의한 양의 상관관계를 보였으며, 체질량지수를 보정하였을 경우 대사증후군 자체와는 연관성이 없었다. 결론: 폐경 후 여성에서 난포 자극 호르몬의 증가 및 복부비만은 혈청 렙틴 농도를 증가시킨다. 렙틴과 대사증후군의 기타 다른 위험인자들, 심혈관 질환의 위험성과의 관련성 규명에 대한 더 깊은 연구가 필요하다.

Keywords

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