Journal of The Korean Ophthalmological Society (대한안과학회지)

The Korean Ophthalmological Society (대한안과학회)
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Correlation Between Multifocal Electroretinography and Visual Acuity After Resolution of Diabetic Macular Edema

당뇨황반부종에서 다국소 망막전위도검사와 치료 후 시력과의 상관관계

Lee, Kwan-Hoon;Chang, Moo-Hwan;Ahn, Jung-Hyun
이관훈;장무환;안정현

  • Published : 20100100
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Abstract

Purpose: To evaluate the prognostic value of multifocal electroretinography (mfERG) after a decrease of retinal thickness in eyes with diabetic macular edema (DME). Methods: Sixty patients (60 eyes) underwent intravitreal injection of triamcinolone acetonide or bevacizumab for diabetic macular edema. Eyes were divided into three groups, according to foveal thickness : Group A (<500 $\mu$m, n=20 eyes), Group B (500 $\mu$m≦<800 $\mu$m, n=20 eyes), and Group C (≧800 $\mu$m, n=20 eyes). Best-corrected visual acuity (BCVA) and mfERG responses from the most central seven hexagons were analyzed both before and after treatment. Results: The pre-injection P1 amplitudes of mfERG correlated significantly with end-point BCVA in Groups A and B (p<0.05), but did not correlate with end-point BCVA (p>0.05) in Group C. Conclusions: The level of P1 amplitudes of mfERG may be a useful tool to predict visual outcomes after a decrease of retinal thickness in patients with diabetic macular edema.

목적: 당뇨황반부종 환자에서 치료 전에 다국소 망막전위도를 측정하여 황반부종을 치료한 후 시력예후를 예측해 보고자 하였다. 대상과 방법: 당뇨황반부종으로 시력저하를 호소하는 환자 60명 60안을 중심와 두께를 기준으로 500 $\mu$m 미만, 500 $\mu$m 이상 800 $\mu$m 미만, 800 $\mu$m 이상을 각각 20안씩 A, B, C군으로 분류하였고, 유리체 내에 triamcinolone acetonide (4 mg/0.1 ml) 또는 bevacizumab (1.25 mg/0.05)을 주사하였다. 주사 전과 황반부종이 치료된 시점에 최대교정시력과 다국소 망막전위도를 검사하여 황반부의 P1진폭을 측정하였다. 결과: 주사 전 황반부의 P1 진폭과 치료종결시점에서의 최대교정시력과의 관계는 A군(r=-0.772, p<0.001)과 B군(r=-0.651, p=0.001) 에서는 통계적으로 유의한 상관관계를 보였으나 C군에서는 유의한 상관관계가 없었다(r=-0.108, p=0.652, Spearman correlation test). 결론: 다국소 망막전위도검사를 통한 황반부 P1 진폭 측정이 당뇨황반부종 환자의 치료 후 시력 예후를 예측하는 데 유용할 것으로 생각된다.

Keywords

References

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