Annals of dermatology

Korean Dermatological Association (대한피부과학회)
권호 표지
DOI QR코드

DOI QR Code

Analysis of MAST-CLA Results as a Diagnostic Tool in Allergic Skin Diseases

Shin, Jung-Won;Jin, Seon-Pil;Lee, Jong-Hee;Cho, So-Yun

  • Published : 20100000
⟨ Previous Next ⟩

Abstract

Background: Urticaria and atopic dermatitis are representative allergic skin diseases that can be mediated by IgE. Measuring levels of specific IgE can be used to confirm causative agents of these skin diseases. Objective: To analyze results from the multiple allergosorbent test chemiluminescent assay (MAST-CLA), which measures specific IgE in the presence of a causative agent/allergen, in IgE-mediated skin diseases. Methods: A total of 404 patients with urticaria, atopic dermatitis or pruritus were enrolled in the present study. Positive rates of specific IgE as well as total serum IgE from the MAST-CLA were compared. Results: Positive rates of specific IgE were highest in atopic dermatitis patients, followed by urticaria, and then pruritus, with 57.0%, 37.1%, and 20.8%, respectively (p<0.05). House dust mite species were the most common allergens in both atopic dermatitis and urticaria skin diseases. There were no differences in the overall MAST-CLA results between acute and chronic urticaria. The relative positive rate of inhalant allergen was significantly higher in adult than in child atopic dermatitis patients. Conclusion: Results from the MAST-CLA showed diversity among the three disease groups, and within each disease group, with different positive rates of specific IgE, a different mean allergen number per patient, and so on. Therefore, we concluded that MAST-CLA could be a useful diagnostic tool for various allergic skin diseases.

Keywords

References

  1. Lee IW, Kim TH, Ahn SK, Choi EH. Comparison of MAST chemiluminescent assay(MAST-CLA) with skin prick, test in patients with atopic dermatitis. Korean J Dermatol 1999;37:297-304
  2. Scolozzi R, Boccafogli A, Vicentini L, Baraldi A, Bagni B. Correlation of MAST chemiluminescent assay (CLA) with RAST and skin prick tests for diagnosis of inhalant allergic disease. Ann Allergy 1989;62:193a-193b
  3. Lee YJ, Park CW, Lee CH. A study of patients with chronic urticaria using the chemiluminescent assay and prick test. Korean J Dermatol 1995;33:260-267
  4. Finnerty JP, Summerell S, Holgate ST. Relationship between skin-prick tests, the multiple allergosorbent test and symptoms of allergic disease. Clin Exp Allergy 1989;19:51-56 https://doi.org/10.1111/j.1365-2222.1989.tb02343.x
  5. Kim HD, Cho MK, Lee SY, Lee JS, Park YL, Whang KU, et al. Evaluation of the MAST CLA allergy system for measuring total and allergen specific IgE in child and adult atopic dermatitis. Korean J Dermatol 2007;45:413-421
  6. Lee EJ, Piao YJ, Kim KH, Suhr KB, Lee JH, Park JK. The relationship among the clinical evaluation, total IgE, and allergen-specific IgE of MAST-CLA in atopic dermatitis. Korean J Dermatol 2003;41:197-206
  7. Lee CS, Tang RB, Chung RL. The evaluation of allergens and allergic diseases in children. J Microbiol Immunol Infect 2000;33:227-232
  8. Park KI, Chun HS, Shin JW, Kim HS, Song KS. Allergen frequencies on MAST CLA by age groups using new Korean panel. J Clin Pathol Qual Control 1999;21:243-249
  9. Cho YW, Park HS, Oh SH, Hong CS. Immediate skin reactivity to 12 inhalant allergens in a general population of Korea. J Korean Med Assoc 1987;30:647-656
  10. Tanei R, Katsuoka K. Clinical analyses of atopic dermatitis in the aged. J Dermatol 2008;35:562-569 https://doi.org/10.1111/j.1346-8138.2008.00524.x
  11. Miyamoto T, Oshima S, Ishizaki T, Sato SH. Allergenic identity between the common floor mite (Dermatophagoides farinae Hughes, 1961) and house dust as a causative antigen in bronchial asthma. J Allergy 1968;42:14-28 https://doi.org/10.1016/0021-8707(68)90128-7
  12. Voorhorst R, Spieksma FTM, Varekamp H, Leupen MJ, Lyklema AW. The house-dust mite (Dermatophagoides pteronyssinus) and the allergens it produces. Identity with the house-dust allergen. J Allergy 1967;39:325-339 https://doi.org/10.1016/0021-8707(67)90045-7
  13. Tang RB, Tsai LC, Hung MW, Hwang B, Wu KG. Detection of house dust mite allergens and immunoblot analysis in asthmatic children. J Asthma 1988;25:83-88 https://doi.org/10.3109/02770908809071358
  14. Tang RB, Chang HN, Lin FM, Chang YF, Chou NS, Lin CY. Serum IgE, skin and radioallergosorbent tests for house dust and mites in asthmatic children. J Asthma 1986;23:245-249 https://doi.org/10.3109/02770908609073168
  15. Teplitsky V, Mumcuoglu KY, Babai I, Dalal I, Cohen R, Tanay A. House dust mites on skin, clothes, and bedding of atopic dermatitis patients. Int J Dermatol 2008;47:790-795 https://doi.org/10.1111/j.1365-4632.2008.03657.x
  16. Kang JS, Lee K, Han SB, Ahn JM, Lee H, Han MH, et al. Induction of atopic eczema/dermatitis syndrome-like skin lesions by repeated topical application of a crude extract of Dermatophagoides pteronyssinus in NC/Nga mice. Int Immunopharmacol 2006;6:1616-1622 https://doi.org/10.1016/j.intimp.2006.06.011
  17. Oshio T, Sasaki Y, Funakoshi-Tago M, Aizu-Yokota E, Sonoda Y, Matsuoka H, et al. Dermatophagoides farinae extract induces severe atopic dermatitis in NC/Nga mice, which is effectively suppressed by the administration of tacrolimus ointment. Int Immunopharmacol 2009;9:403-411 https://doi.org/10.1016/j.intimp.2008.12.013
  18. Kato T, Takai T, Fujimura T, Matsuoka H, Ogawa T, Murayama K, et al. Mite serine protease activates proteaseactivated receptor-2 and induces cytokine release in human keratinocytes. Allergy 2009;64:1366-1374 https://doi.org/10.1111/j.1398-9995.2009.02023.x
  19. Maeda S, Shibata S, Chimura N, Fukata T. House dust mite major allergen Der f 1 enhances proinflammatory cytokine and chemokine gene expression in a cell line of canine epidermal keratinocytes. Vet Immunol Immunopathol 2009;131:298-302 https://doi.org/10.1016/j.vetimm.2009.04.012
  20. Host A. Cow's milk protein allergy and intolerance in infancy. Some clinical, epidemiological and immunological aspects. Pediatr Allergy Immunol 1994;5(5 Suppl):1-36 https://doi.org/10.1111/j.1399-3038.1994.tb00210.x
  21. Chang DS, Seo SJ, Hong CK. Patch test and specific IgE level with food antigens in atopic dermatitis patients. Korean J Dermatol 2002;40:1028-1034
  22. Purohit A, Shao J, Degreef JM, van Leeuwen A, van Ree R, Pauli G, et al. Role of tropomyosin as a cross-reacting allergen in sensitization to cockroach in patients from Martinique (French Caribbean island) with a respiratory allergy to mite and a food allergy to crab and shrimp. Eur Ann Allergy Clin Immunol 2007;39:85-88
  23. Caliskaner Z, Ozturk S, Turan M, Karaayvaz M. Skin test positivity to aeroallergens in the patients with chronic urticaria without allergic respiratory disease. J Investig Allergol Clin Immunol 2004;14:50-54

Cited by

  1. House Dust Mite Allergy in Korea: The Most Important Inhalant Allergen in Current and Future vol.4, pp.6, 2012, https://doi.org/10.4168/aair.2012.4.6.313
  2. Clinical Availability of Component-Resolved Diagnosis Using Microarray Technology in Atopic Dermatitis vol.26, pp.4, 2010, https://doi.org/10.5021/ad.2014.26.4.437
  3. Avoidance Behavior against Positive Allergens Detected with a Multiple Allergen Simultaneous Test Immunoblot Assay in Patients with Urticaria: Factors Associated with Avoidance Success/Failure vol.28, pp.1, 2010, https://doi.org/10.5021/ad.2016.28.1.80
  4. Food Allergy in Korean Patients with Chronic Urticaria vol.28, pp.5, 2016, https://doi.org/10.5021/ad.2016.28.5.562
  5. Filaggrin Mutation in Korean Patients with Atopic Dermatitis vol.58, pp.2, 2010, https://doi.org/10.3349/ymj.2017.58.2.395
  6. Comparison of Intradermal Skin Test and Multiple Allergen Simultaneous Test Results in Canine Atopic Dermatitis vol.38, pp.3, 2010, https://doi.org/10.17555/jvc.2021.38.3.120
  7. Assessment of urticaria using a self‐reported diagnosis tool (SRUD): a multicentre validation study vol.35, pp.10, 2021, https://doi.org/10.1111/jdv.17277