Korean Journal of Fisheries and Aquatic Sciences (한국수산과학회지)

The Korean Society of Fisheries and Aquatic Science (한국수산과학회)
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Separation and Purification of Antihypertensive Substances from Edible Seaweeds

해조류로부터 항고혈압성분의 분리정제

  • Lee, Seung-Joo (Department of Food Processing and Distribution, Gangneung-Wonju National University) ;
  • Ha, Wang-Hyun (Department of Food Processing and Distribution, Gangneung-Wonju National University) ;
  • Choi, Hye-Jin (Department of Food Processing and Distribution, Gangneung-Wonju National University) ;
  • Cho, Soon-Yeong (Department of Food Processing and Distribution, Gangneung-Wonju National University) ;
  • Choi, Jong-Won (College of Pharmacy, Kyungsung University)
  • 이승주 (강릉원주대학교 식품가공유통학과) ;
  • 하왕현 (강릉원주대학교 식품가공유통학과) ;
  • 최혜진 (강릉원주대학교 식품가공유통학과) ;
  • 조순영 (강릉원주대학교 식품가공유통학과) ;
  • 최종원 (경성대학교 약학대학)
  • Received : 2010.08.11
  • Accepted : 2010.10.04
  • Published : 2010.10.31
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Abstract

To isolate natural antihypertensive substances from edible seaweeds, we screened for and separated active compounds contained in natural Underia pinnatifida, cultural Underia pinnatifida, Laminaria japonica, Sporophylls and Agarum cribrosum. They were extracted using room temperature water, boiling water, acetone, and methanol in turn or using room temperature water, ether, acetone, methanol and boiling water in order. The in vitro antihypertensive activity was quantified as inhibitory efficacy against angiotensin-I converting enzyme (ACE), which is a factor inducing hypertension. For all of the seaweeds tested, the fractions soluble in room temperature water and in boiling water showed the strongest ACE inhibitory effect among the extracted fractions. Conversely, the methanol-extracted fractions for all of the seaweeds tested showed no antihypertensive activity. While the ether and acetone fractions had slight antihypertensive effects. The compounds in the aqueous extracts that had antihypertensive activity were presumed to be polysaccharides, such as fucoidan and alginate.

Keywords

References

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