Korean Journal of Fisheries and Aquatic Sciences (한국수산과학회지)

The Korean Society of Fisheries and Aquatic Science (한국수산과학회)
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Distribution of Fluoroquinolones in the Carp (Cyprinus carpio) and Eel (Anguilla japonica) following their Oral Administration

양식 잉어 및 뱀장어에 경구투 fluoroquinolone계 항생제의 체내 잔류량의 변화

  • 조미라 (국립수산과학원 남서해수산연구소) ;
  • 박큰바위 (국립수산과학원 남서해수산연구소) ;
  • 이희정 (국립수산과학원 남서해수산연구소) ;
  • 김지회 (국립수산과학원 남동해수산연구소) ;
  • 이태식 (국립수산과학원 서해수산연구소) ;
  • 정승희 (국립수산과학원 전략양식연구소) ;
  • 이두석 (국립수산과학원 식품안전과) ;
  • 윤호동 (국립수산과학원 식품안전과) ;
  • 김풍호 (국립수산과학원 식품안전과)
  • Received : 2010.09.06
  • Accepted : 2010.12.03
  • Published : 2010.12.31
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Abstract

The distribution of fluoroquinolones was investigated in the carp (Cyprinus carpio) and eel (Anguilla japonica) after an oral dose of 20 mg/kg body weight/day for 35 days. Blood samples were collected at 5 and 10 hours and 1, 2, 3, 5, 7, 9, 13, 20, 30, and 35 days after treatment. The fluoroquinolone concentrations were determined high- performance liquid chromatography with an ultraviolet detector. The recovery rates of fluoroquinolones in the fish samples ranged from 91.4-96.6, 91.2-96.5, and 90.4-98.6% for concentrations of 0.1, 0.5, and $1.0\;{\mu}g/g$, respectively. In the blood of carp, ciprofloxacin, enrofloxacin, norfloxacin, and sarafloxacin reached maximums level of 11.03, 9.37, 9.10, and $9.81\;{\mu}g/g$ 10 hours, 1 day, 10 hours, and 10 hours after treatment, respectively. In the eel blood, these reached maximum levels of 12.65, 11.18, 11.91, and $8.74\;{\mu}g/g$ all at 10 hours. Carp sample concentrations of ciprofloxacin, enrofloxacin, norfloxacin, and sarafloxacin were not measurable 20, 30, 20, and 20 days after treatment, respectively, in all experiments (

Keywords

References

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