Journal of Acupuncture Research

Korean Acupuncture & Moxibustion Medicine Society (대한침구의학회)
권호 표지

Clinical Study of Acupuncture Theraphy of Gastrointestinal Side Effect of Levodopa: Focused on Idiopathic Pakinson's Disease Patients

레보도파제제의 위장관계 부작용에 대한 침치료 효과 연구－특발성 파킨슨병 환자를 대상으로－

  • Yang, Dong-Ho (Department of Acupuncture & Moxibustion, Dongsuwon Oriental Medical Hospital) ;
  • Lee, Kyung-Yun (Department of Acupuncture & Moxibustion, Dongsuwon Oriental Medical Hospital) ;
  • Shin, Hyun-Seung (Department of Acupuncture & Moxibustion, Dongsuwon Oriental Medical Hospital) ;
  • Jo, Song-Hyun (Department of Acupuncture & Moxibustion, Dongsuwon Oriental Medical Hospital) ;
  • Lim, Chang-Sun (Department of Oriental Rehabilitation Medicine, Dongsuwon Oriental Medical Hospital) ;
  • Lim, Jun-Hyuk (Department of Oriental Rehabilitation Medicine, Dongsuwon Oriental Medical Hospital) ;
  • Yun, Suk-Hoon (Department of Oriental Rehabilitation Medicine, Dongsuwon Oriental Medical Hospital) ;
  • Lee, Han (Department of Acupuncture & Moxibustion, Seoul Ja-saeng Oriental Medical Hospital) ;
  • Kang, Myoung-Jin (Department of Oriental Rehabilitation Medicine, Buchon Ja-Saeng Oriental Medical Hospital)
  • 양동호 (동수원한방병원 한방침구과) ;
  • 이경윤 (동수원한방병원 한방침구과) ;
  • 신현승 (동수원한방병원 한방침구과) ;
  • 조송현 (동수원한방병원 한방침구과) ;
  • 임창선 (동수원한방병원 한방재활의학과) ;
  • 임준혁 (동수원한방병원 한방재활의학과) ;
  • 윤석훈 (동수원한방병원 한방재활의학과) ;
  • 이한 (서울자생한방병원 침구과) ;
  • 강명진 (부천자생한방병원 한방재활의학과)
  • Received : 2010.09.09
  • Accepted : 2010.10.25
  • Published : 2010.12.20
Download PDF
⟨ Previous Next ⟩

Abstract

Objective : This study was aimed at investigating the therapeutic effects of acupuncture on gastrointestinal side effect of Levodopa on idiopathic Pakinson's disease patients. Methods : The subjects of this study were 42 patients with idiopathic Parkinson's disease. We divided them into two groups; acupuncture treatment group, no treatment group. We treated the former group with acupuncture therapy focusing on gastrointestinal side effect of Levodopa while administering Levodopa as well. And the latter group was also dosed up with Levodopa without acupuncture therapy. To see the effect of acupuncture treatment clearly, we used gastrointestinal syndrome rating scale (GSRS) and visual analog scale (VAS) and compared the GSRS grade and VAS score of two groups statistically, after 1, 2, 3, 4 weeks since they have been under the treatment. Results : This study suggests that the group who has been treated with acupuncture on gastrointestinal side effect of Levodopa on idiopathic pakinson's disease patients showed higher GSRS grade and VAS score than the one that has not. But, We could't find statistical significance between the two groups on improvement of GSRS grade and VAS score. Conclusions : These results proved that acupucture theraphy might be available for re lieving symptoms related with gastrointestinal side effect of Levodopa than the one that has not. But further studies are necessary.

Keywords

References

  1. Hoehn MM, Yahr MD. Parkinsonism : onset, progress, and mortality. Neurology. 1967 ; 17 : 427-42. https://doi.org/10.1212/WNL.17.5.427
  2. 김진구, 최경규, 이명식. 최신 신경학. 서울 : (주) 과학서적쎈터. 2000 : 331, 365.
  3. 박상민, 이상훈, 인창식, 강미경, 장대일, 강성길, 이윤호. 파킨슨병의 한의학적 고찰. 대한침구학회지. 2004 ; 21(1) : 202-10.
  4. Raymond D. Adams, Maurice Victor, Allan H Ropper. Principles of neurology. 서울 : 도서출판 정담. 1998 : 980-7.
  5. 하지영, 이상훈, 인창식, 박상민, 강중원, 장대일, 이윤호. 특발성 파킨슨병 환자의 증상에 대한 침치료 효과. 대한한의학회지. 2003 ; 24(3) : 172- 83.
  6. 김진원, 김병철, 우성호, 나유진, 심효주, 이원희, 이지영, 서호석, 김용호, 정병주. 파킨슨병으로 유발된 진전이 한약 치료를 통하여 호전된 치험 1례. 대한한방내과학회지. 2006 ; 27(4) : 954-61.
  7. 박상민, 이상훈, 강미경, 정지철, 박희준, 임사비나, 장대일, 이윤호. 특발성 파킨슨 환자의 뜸 치료 효과. 대한침구학회지. 2005 ; 22(1) : 91-7.
  8. 양재철, 김성근, 이경윤, 김주영, 구범모. 뇌교 경색을 동반한 파킨슨병 환자의 소시호탕(小柴胡湯) 치험 예. 대한한의학회지. 2007 ; 28(2) : 34-43.
  9. Charles D Forbes, William F Jackson. 임상의학. 서울 : 한우리. 1998 : 503-04.
  10. 서울대학교 의과대학 약리학교실. 약리학. 서울 : 고려의학. 1994 : 287-90.
  11. 주강 주편. 임상 중의 뇌병학. 서울 : 북경과학출판사. 1997 : 182-5.
  12. 전국한의과대학 비계 내과학 교수 공저. 비계 내과학. 서울 : 아트동방. 1998 : 83-5, 158.
  13. 왕빙. 황제내경소문. 대만중화서국. 1972 : 370-2.
  14. 안희덕, 안규석. 구토의 병리에 관한 문헌적 고찰. 동의병리학회지. 1993 ; 8(1) : 259-72.
  15. 성일환, 채우석. 구토의 원인․병증․治法 및 침치료혈에 대한 문헌적 고찰. 대한침구학회지. 1995 ; 12(1) : 79-95.
  16. Svedlund J, Sjodin I, Dotevall G․GSRS-a clinical rating scale for gastrointenstinal symptoms in patients with irritable bowel syndrome and peptic ulcer disease. Dig Dis Sci. 1988 ; 33(2) : 129- 34. https://doi.org/10.1007/BF01535722
  17. Dinan TG, O Keane V, O Boyle C, Chua A, Keeling PW. A comparison of the mental status, personality profiles and life events of patients with irritable bowel syndrome and peptic ulcer disease. Acta Psychiatr Scand. 1991 ; 84(1) : 26-8.
  18. Dimenas E, Glise H, Hallerback B, Hernqvist H, Svedhnd J, Wiklund I. Quality of life in patient with uppergaatrointestianal symptoms. An improved evaluation of treatment regimens? Scand J Gastroenterol. 1993 ; 28(8) : 681-7. https://doi.org/10.3109/00365529309098272
  19. 전국한의과대학 침구․경혈학교수 편저. 침구학(하). 서울 : 집문당. 2005 : 1315-9.
  20. Rajendran PR, Thompson RE, Reich SG. The use of alternative therapies by patients with Parkinson's disease. Neurology. 2001 ; 57(5) : 790-4. https://doi.org/10.1212/WNL.57.5.790
  21. 안영기. 경혈학총서. 서울 : 성보사. 2002 : 169, 223, 224, 226, 576, 582, 677.