Journal of Nutrition and Health

The Korean Nutrition Society (한국영양학회)
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Antihypertensive Properties of Dried Radish Leaves Powder in Spontaneously Hypertensive Rats

자연발증적 고혈압 흰쥐에서 무청 건조분말의 항고혈압 효과

  • Kim, Bo-Ram (Department of Food & Nutrition, Kookmin University) ;
  • Park, Ji-Ho (Department of Food & Nutrition, Kookmin University) ;
  • Kim, Sun-Hee (Department of Food & Nutrition, Kookmin University) ;
  • Cho, Kang-Jin (Department of Functional Food & Nutrition Division, Rural National Academy of Agricultural Science) ;
  • Chang, Moon-Jeong (Department of Food & Nutrition, Kookmin University)
  • 김보람 (국민대학교 자연과학대학 식품영양학과) ;
  • 박지호 (국민대학교 자연과학대학 식품영양학과) ;
  • 김선희 (국민대학교 자연과학대학 식품영양학과) ;
  • 조강진 (국립농업과학원 기능성식품과) ;
  • 장문정 (국민대학교 자연과학대학 식품영양학과)
  • Received : 2010.11.05
  • Accepted : 2010.11.25
  • Published : 2010.12.31
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Abstract

The study aim was to investigate the antihypertensive effect after oral supplementation of dried radish leaves powder (DRLP). Angiotensin-converting enzyme (ACE) activity was measured by spectrophotometric assay. The systolic blood pressure (SBP) was measured in spontaneously hypertensive (SHR) and normotensive rats (Wistar) by the tail cuff method after a 4-week diet with DRLP at the level of 2.5% or 5%. The supplementation of DRLP decreased SBP of SHR although the 5% supplementation level did not show any more pronounced effect than the 2.5% level did. The decrease in the SBP observed for both 2.5% and 5% DRLP was accompanied by significant increases of the urinary Na and K excretion. The DRLP supplementation showed a potent ACE-inhibitory activity in pulmonary tissue from both hypertensive and normotensive rats. However, the DRLP supplementation did not affect the SBP in normotensive rats. These results indicated that DRLP exerted an antihypertensive effect in SHR due to the decreased ACE activity and increased urinary Na excretion.

Keywords

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