Experimental and Molecular Medicine

Korean Society for Biochemistry and Molecular Biongy (생화학분자생물학회)
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Systemic LPS administration induces brain inflammation but not dopaminergic neuronal death in the substantia nigra

  • Jeong, Hey-Kyeong (Neuroscience Graduate Program Ajou University School of Medicine) ;
  • Jou, Il-O (Neuroscience Graduate Program Ajou University School of Medicine) ;
  • Joe, Eun-Hye (Neuroscience Graduate Program Ajou University School of Medicine)
  • Accepted : 2010.10.18
  • Published : 2010.12.31
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Abstract

It has been suggested that brain inflammation is important in aggravation of brain damage and/or that inflammation causes neurodegenerative diseases including Parkinson's disease (PD). Recently, systemic inflammation has also emerged as a risk factor for PD. In the present study, we evaluated how systemic inflammation induced by intravenous (iv) lipopolysaccharides (LPS) injection affected brain inflammation and neuronal damage in the rat. Interestingly, almost all brain inflammatory responses, including morphological activation of microglia, neutrophil infiltration, and mRNA/protein expression of inflammatory mediators, appeared within 4-8 h, and subsided within 1-3 days, in the substantia nigra (SN), where dopaminergic neurons are located. More importantly, however, dopaminergic neuronal loss was not detectable for up to 8 d after iv LPS injection. Together, these results indicate that acute induction of systemic inflammation causes brain inflammation, but this is not sufficiently toxic to induce neuronal injury.

Keywords

Acknowledgement

Supported by : KOSEF, Chronic Inflammatory Disease Research Center (CIDRC) at Ajou University

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  30. Anthocyanins control neuroinflammation and consequent memory dysfunction in mice exposed to lipopolysaccharide vol.54, pp.5, 2010, https://doi.org/10.1007/s12035-016-9900-8
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  35. The Healing Effect of Human Milk Fat Globule-EGF Factor 8 Protein (MFG-E8) in A Rat Model of Parkinson’s Disease vol.8, pp.9, 2010, https://doi.org/10.3390/brainsci8090167
  36. The small molecule CA140 inhibits the neuroinflammatory response in wild-type mice and a mouse model of AD vol.15, pp.None, 2010, https://doi.org/10.1186/s12974-018-1321-3
  37. Colony-stimulating factor 1 receptor inhibition prevents disruption of the blood-retina barrier during chronic inflammation vol.15, pp.None, 2010, https://doi.org/10.1186/s12974-018-1373-4
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  43. Diosgenin Prevents Microglial Activation and Protects Dopaminergic Neurons from Lipopolysaccharide-Induced Neural Damage In Vitro and In Vivo vol.22, pp.19, 2010, https://doi.org/10.3390/ijms221910361
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