The Korean Journal of Mycology (한국균학회지)

The Korean Society of Mycology (한국균학회)
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Screening of Anti-gout Xanthine Oxidase Inhibitor from Mushrooms

버섯류로부터 항통풍성 Xanthine oxidase 저해물질의 탐색

  • Zanabaatar, Bolormaa (Department of Life Science and Genetic Engineering, Paichai University) ;
  • Song, Jung-Hwa (Department of Life Science and Genetic Engineering, Paichai University) ;
  • Seo, Geon-Sik (Korea National College of Agriculture and Fisheries) ;
  • Noh, Hyung-Jun (National Institute of Horticultural & Herbal Science) ;
  • Yoo, Young-Bok (National Institute of Horticultural & Herbal Science) ;
  • Lee, Jong-Soo (Department of Life Science and Genetic Engineering, Paichai University)
  • Received : 2010.06.16
  • Accepted : 2010.06.19
  • Published : 2010.06.30
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Abstract

Anti-gout xanthine oxidase inhibitory activity of water extracts from various mushrooms were determined. The highest xanthine oxidase inhibitory activity was 72.9% in the water extract from fruiting body of Agaricus brazillensis and also were high in the extract from fruiting bodies of Pleurotus salmoneostramineus(60.1%), Phellinus baumii(57.7%), Agaricus bisporus(56.7%) and Hericium erinaceum(53.4%). The xanthine oxidase inhibitor was maximally extracted when Agaricus brazillensis fruiting body was treated with water at $30^{\circ}C$ for 24 h.

버섯으로부터 새로운 항통풍성 소재를 개발하여 이를 대체의약의 소재나 건강 기능성 제품 개발에 응용할 수 있는 자료를 얻고자 12종의 국내 버섯 자실체들의 물 추출물을 제조하여 이들의 항통풍성 xanthine oxidase 저해 활성을 측정하였다. 시료 버섯 가운데 신령 버섯 자실체의 물 추출물이 가장 높은 72.9%의 저해 활성을 보였고 이 저해 물질은$30^{\circ}C$에서 24시간 추출하였을 때 가장 많이 용출 되었다.

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References

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