Tuberculosis and Respiratory Diseases

The Korean Academy of Tuberculosis and Respiratory Diseases (대한결핵및호흡기학회)
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Longitudinal Evaluation of Lung Function Associated with Emphysema in Healthy Smokers

건강한 흡연자에서 폐기종의 유무에 따른 폐기능 변화

  • Sim, Yun-Su (Department of Health Promotion Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea College of Medicine) ;
  • Ham, Eun-Jae (Department of Health Promotion Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea College of Medicine) ;
  • Choi, Kyu-Yong (Department of Health Promotion Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea College of Medicine) ;
  • Lee, Suk-Young (Department of Respiratory and Critical Care Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea College of Medicine) ;
  • Kim, Seok-Chan (Department of Respiratory and Critical Care Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea College of Medicine) ;
  • Kim, Young-Kyoon (Department of Respiratory and Critical Care Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea College of Medicine) ;
  • Park, Sung-Hak (Department of Respiratory and Critical Care Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea College of Medicine)
  • 심윤수 (가톨릭대학교 의과대학 서울성모병원 건강증진의학과) ;
  • 함은재 (가톨릭대학교 의과대학 서울성모병원 건강증진의학과) ;
  • 최규용 (가톨릭대학교 의과대학 서울성모병원 건강증진의학과) ;
  • 이숙영 (가톨릭대학교 의과대학 서울성모병원 내과학교실 호흡기내과) ;
  • 김석찬 (가톨릭대학교 의과대학 서울성모병원 내과학교실 호흡기내과) ;
  • 김영균 (가톨릭대학교 의과대학 서울성모병원 내과학교실 호흡기내과) ;
  • 박성학 (가톨릭대학교 의과대학 서울성모병원 내과학교실 호흡기내과)
  • Received : 2010.05.13
  • Accepted : 2010.08.26
  • Published : 2010.09.30
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Abstract

Background: Smoking reduces pulmonary function and induces various lung diseases. Recently, the rate of emphysema detection has increased due to lung cancer screening with low-dose chest computed tomography (CT). The purpose of this study was to evaluate changes in lung function associated with emphysema in healthy smokers. Methods: One hundred and ninety one healthy smokers, who had undergone a low-dose chest CT (LDCT) scan as part of lung cancer screening and had revisited the health center after a median 23.9 months' time, were recruited into this study. The severity of emphysema was calculated by the direct observation of a radiologist and a pulmonologist indipendently. Longitudinal changes in lung function according to emphysema based on LDCT and type of smoker was analyzed. Results: Of the participants in this study, 25% of healthy smokers had emphysema, which was mild in severity, in older patients (p=0.003) and in heavy smokers (p<0.001). $FEV_1/FVC$ and FEF25-75% were decreased in current smokers with emphysema (p=0.001 and p=0.009, respectively) and without emphysema (p=0.001 and p=0.042). Although lung function was not decreased in ex-smokers without emphysema, $FEV_1/FVC$ and FEF25-75% were decreased in ex-smoker with emphysema (p=0.020 and p=0.010). Conclusion: Upon examination with LDCT, the prevalence of emphysema was higher in healthy smokers was than in non-smokers. Lung function was diminished in smokers with emphysema, in spite of former smoker.

Keywords

References

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