The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
권호 표지
DOI QR코드

DOI QR Code

Inhibitory Effect of a Decoction of Eucommiae ulmides OLIVER and Dipsacus asperoides C. Y. Cheng et T.M.Ai on Collagen II-induced Arthritis Mice

Collagen II-induced Arthritis 생쥐에 대한 두충(杜仲).속단(續斷) 배합약물의 관절염 억제 효과

  • Lee, Boo-Kyun (Samzon Oriental Clinic) ;
  • Lee, Young-Cheol (Dept. of Herbbology, College of Oriental Medicine, Sangji University) ;
  • Lee, Jang-Cheon (Dept. of Prescriptionology, School of Oriental Medicine, Pusan National University)
  • 이부균 (삼존한의원) ;
  • 이영철 (상지대학교 한의과대학 본초학교실) ;
  • 이장천 (부산대학교 한의학전문대학원 본초방제학교실)
  • Received : 2010.02.19
  • Accepted : 2010.03.22
  • Published : 2010.03.30
Download PDF
⟨ Previous Next ⟩

Abstract

Objectives : The object of this study was to verify the inhibitory effect of a decoction of Eucommiae ulmides OLIVER (EU) and Dipsacus asperoides C. Y. Cheng et T.M.Ai (DA) on Collagen II-induced Arthritis Mice (CIA mice). Methods : DBA/1OlaHsd mice were immunized with bovine type II collagen. Boostnig same collagen 21 days later, arthritis was induced and then administrated orally the extract of EU+DA (200 or 50 mg/kg) once a day for 4 weeks and compared with that of methotrexate (MTX, 0.3 mg/kg) as a positive control. Results : Administration of EU+DA suppressed the inflammatory progression of CIA mice and the results were 1. Arthritis index of CIA mice was decreased. 2. EU+DA decreased the production of TNF-$\alpha$, IL-6, IL-$1{\beta}$ in the serum of CIA mice. 3. EU+DA decreased the level of IgM. 4. EU+DAincreasaed $CD3^+$, $CD4^+$, $CD4^+$/CD25 but decreased $CD19^+$, $CD3^+/CD49b^+$(NKT), $CD3^-/CD49b^+$(NK), $B220^+/CD23^+$ in PBMC of CIA mice. 5. EU+DA decreased $CD3^+$, $CD4^+$, $CD3^+/CD69^+$ of paw joint in CIA mice. 6. EU+DA decreased subsynovial inflammation. Conclusions : This results demonstrated that extract of EU+DA suppressed the inflammatory progression of CIA mice and supported further studies are required to clarify a mechanism of therapeutic role.

Keywords

References

  1. 질병관리본부 만성병조사팀. 2005 건강행태 및 만성질환 통계 자료집. 서울 : 보건복지부. 2006 : 133-4.
  2. 보건복지부. 질병관리본부. 국민건강영양조사 제4기 1차년도(2007). 서울 : 질병관리본부. 2008 : 76.
  3. 대한정형외과학회. 정형외과. 6판. 서울 : 최신의학사. 2006 : 226.
  4. 대한정형외과학회. 정형외과. 6판. 서울 : 최신의학사. 2006 : 229-31.
  5. 李今庸 主編. 新編黃帝內經綱目. 上海 : 上海科學技術出版社. 1988 : 262.
  6. 한의과대학 본초학편집위원회. 본초학. 서울 : 영림사. 2004 : 605.
  7. 한방약리학 교재편찬위원회. 약리학. 서울 : 신일상사. 1992 : 421-2.
  8. 최도영 외. 류마티스 관절염에 대한 한약의 면역학적 연구동향. 대한침구학회지. 2004 ; 21(4) : 177-96.
  9. 임창경. 이묘산의 항류마티즘 효능에 대한 연구. 원광대학교 대학원 한의학과. 2003.
  10. 송인광 외. 쥐의 콜라젠 유도 관절염에 대한 유근피의 효과 및 기전. 대한침구학회지. 2007 ; 24(2) : 83-100.
  11. 김양진. 콜라젠 유도에 의한 CIA 관절염 생쥐에 대한 백개자의 억제 효과. 상지대학교 대학원 한의학과. 2008.
  12. 이승혁 편역. 신편 임상약대론. 서울 : 의성당. 2007 : 292.
  13. 강호영 외 공역. 면역학(Thomas J Kindt. et al. Immunology(vol. 6)). 6판. 서울 : 월드사이언스. 2008 : 411
  14. 김정철 외 공역. 한눈에 알 수 있는 면역학. 8판. 서울 : E pubric. 2006 : 81.
  15. J.M. Dayer et al. Antiinterleukin-1 therapy in rheumatic diseases. Curr Opin Rheumatol. 2001 ; 13 : 170-6. https://doi.org/10.1097/00002281-200105000-00004
  16. 강호영 외 공역. 면역학(Thomas J Kindt. et al. Immunology.(Vol. 6)). 6판. 서울 : 월드사이언스. 2008 : 414.
  17. Choy EH, Panayi GS. Cytokine pathway and joint inflammation in rheumatoid arthritis. N Engl J Med. 2001 ; 344 : 907-16. https://doi.org/10.1056/NEJM200103223441207
  18. 대한정형외과학회. 정형외과. 6판. 서울 : 최신의학사. 2006 : 234-5.
  19. 대한정형외과학회. 정형외과. 6판. 서울 : 최신의학사. 2006 : 253-8.
  20. Ralph Hinton, Col MC, USA et al. Osteoarthritis: Diagnosis and Therapeutic Consideration. American Family Physician. 2002 ; 65(5) : 844.
  21. Altman R et al. The American College of Rheumatology criteria for the classification and reporting of osteoarthritis of the hip. Arthritis Rheum. 1991 ; 34 : 505-14. https://doi.org/10.1002/art.1780340502
  22. Altman R et al. Development of criteria for the classification and reporting of osteoarthritis. Classification of osteoarthritis of the knee. Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Association. Arthritis Rheum. 1986 ; 29 : 1039. https://doi.org/10.1002/art.1780290816
  23. 이연아, 홍승재. 류마티스 관절염의 최신치료 지견. 경희의학. 2007 ; 23(1) : 9-10.
  24. 郭靄春 主編. 黃帝內經素問校注. 北京 : 人民衛生出版社. 1995 : 555-6.
  25. 李克光 主編. 金匱要略. 台北 : 知音出版社. 1994 : 55.
  26. 李克光 主編. 金匱要略. 台北 : 知音出版社. 1994 : 152.
  27. 陈梦雷 等 编. 古今圖書集成 醫部全錄(第六冊). 北京 : 人民衛生出版社. 1988 : 194.
  28. 娄玉鈴. 中國風濕病學. 北京 : 人民衛生出版社. 2001 : 60-3.
  29. 陳存仁. 圖說 漢方醫藥大事典. 第3卷. 東京 : 講談社. 1982 : 192.
  30. 강병수. 이장천 외. 원색 한약보감. 대구 : 동아문화사. 2008 : 214.
  31. 강병수. 이장천 외. 원색 한약보감. 대구 : 동아문화사. 2008 : 482.
  32. 陳存仁. 圖說 漢方醫藥大事典 第3卷. 東京 : 講談社. 1982 : 378.
  33. William N Kelly et al Rheumatoid factors. in Tighe, H and Carson D.A. Textbook of Rheumatology. Ontario : Saunders. 1997 : 241-9.
  34. Coppieters K, Dewint P, Van Beneden K et al. NKT cells : manipulable managers of joint inflammation. Rheumatology. 2007 ; 46 : 565-71.
  35. Kong YY et al. Activated T cells regulate bone loss and joint dectruction in adjuvant arthritis through osteoprotegerin ligand. Nature. 1999 ; 402 : 304-9. https://doi.org/10.1038/46303
  36. Mori L et al Attenuation of collagen-induced arthritis in 55-kDa TNF receptor type 1 (TNFR1)-IgG1-treated and TNFR1-deficient mice. J Immunol. 1996 ; 157 : 3178-82.
  37. Guo-Min Deng, Michael Lenardo. The role of immune cells and cytokines in the pathogenesis of rhuematoid arthritis. Drug discovery Today : Disease Mechanism. 2006 ; 3(2) : 163-8. https://doi.org/10.1016/j.ddmec.2006.06.009