Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Effect of Ginseng-Berry Extract on the Improvement of Blood Microcirculation and Skin Brightness

인삼열매 추출물의 혈행개선과 피부톤 개선에 미치는 영향

  • 김정기 (아모레퍼시픽기술연구원 식품연구소) ;
  • 김병수 (대전대학교 한의학과) ;
  • 박찬웅 (아모레퍼시픽기술연구원 식품연구소) ;
  • 서대방 (아모레퍼시픽기술연구원 식품연구소) ;
  • 유호룡 (대전대학교 한의학과) ;
  • 이상준 (아모레퍼시픽기술연구원 식품연구소)
  • Received : 2010.01.06
  • Accepted : 2010.01.31
  • Published : 2010.02.25
Download PDF
⟨ Previous Next ⟩

Abstract

Several studies have demonstrated that ginseng-berry extract has several beneficial properties, including anti-inflammatory, antioxidant, and vasodilation properties. Ginseng-berry extract has also been shown to have the great potential against skin aging. Its beneficial mechanism against skin aging, however, has not been examined in detail. Also, the effects of ginseng-berry extract on microcirculation and skin cellular responses have not been investigated. Inhibition of skin microcirculation is the primary cause of many adverse biological effects, which is responsible for the skin aging and darkening. We investigated the beneficial effects of ginseng-berry extract on blood circulation, transcutaneous oxygen pressure in vivo model and also on skin microcirculation, cellular response and skin brightening effect in clinical trial. We found that oral administration of ginseng-berry extract markedly increased blood flow rate and transcutaneous $O_2$ pressure, but decreased transcutaneous $CO_2$ pressure. Also, it improved skin tone on cheeks, as is skin brighteness. These results suggest that ginseng-berry extract is a potent candidate for the treatment of skin aging and brightening by improving skin microcirculation.

Keywords

References

  1. 이상준. 피부 미용 효능을 갖는 신규 식이 천연 소재. Food Science and Industry. 40(4):10-18, 2007.
  2. 이숙경. 피부미용과 영양. 서울, 도서출판정담, pp 119-121, 2000.
  3. 黃霏莉. 미용중의학. 북경, 과학출판사, pp 79-89, 1999.
  4. 채윤병, 이승일, 강인정, 이은미. 한방피부미용학 개요. 대한한방피부미용학회, 1(1):145-157, 2005.
  5. 김은주, 안성연, 남개원. 적송엽함유 한방화장품이 인체 피부 노화에 미치는 영향 연구. 대한본초학회지 21(1):25-31, 2006.
  6. Wright, C.I., Croner, C.I., Draijer, R. Non-invasive method and stimuli for evaluating the skin's microcirculation. J. Pharmacol. Toxicol. Methods. 54: 1-25, 2006. https://doi.org/10.1016/j.vascn.2005.09.004
  7. Xie, J.T., Shao, Z.H., Vanden Hoek, T.L., et al. Antioxidant effects of ginsenoside Re in cardiomyocytes. Eur. J. Pharmacol. 532(3):201-207, 2006. https://doi.org/10.1016/j.ejphar.2006.01.001
  8. Attele, A.S., Zhou, Y.P., Xie, J.T., et al. Antidiabetic effects of Panax ginseng berry extract and the identification of an effective component. Diabete. 51(6):1851-1858, 2002. https://doi.org/10.2337/diabetes.51.6.1851
  9. Wang, C.Z., Wu, J.A., McEntee, E., Yuan, C.S. Saponins composition in American ginseng leaf and berry assayed by high-performance liquid chromatography. J. Agric. Food Chem. 54(6):2261-2266, 2006. https://doi.org/10.1021/jf052993w
  10. 김선영, 안덕균, 박성규, 이진영, 김완기, 심영철, 이상준. 한방미용 제재의 hairless mouse model에서의 피부 광노화 억제 및 섬유아세포에서의 UVB 손상 저해 효과. 대한한의학회지 23(3):43-53, 2002.
  11. Katiyar, S.K., Elment, C.A. Green tea polyphenolic antioxidants and skin protection. Int. J. Oncol. 18: 1307-1313, 2001.
  12. Cho, H.S., Kim, S., Lee, S.Y., Park, J.A., Kim, S.J., Chun, H.S. Protective effect of the green tea component, L-theanine on environmental toxins-induced neuronal cell death. Neurotoxicology 29(4):656-662, 2008. https://doi.org/10.1016/j.neuro.2008.03.004
  13. Boldt, J. Clinical review. Hemodynamic monitoring in the intensive care unit. Critical Care, 6: 52-59, 2002. https://doi.org/10.1186/cc1453
  14. Bongard, O., Bounameaux, H. Clinical investigation of skin microcirculation. Dermatology 186: 6-11, 1993. https://doi.org/10.1159/000247295
  15. Yang, W.J., Yang, P.P. Literature survey on biomedical applications of thermography. Biomed. Mat. Engineer. 2: 7-18, 1992.
  16. Van Beekvelt, M.C., Colier, W.N., Wevers, R.A., Van Engelen, B.G. Performance of near-infrared spectroscopy in measuring local O2 consumption and blood flow in skeletal muscle. J. Applied Physiol. 90: 511-519, 2001. https://doi.org/10.1152/jappl.2001.90.2.511
  17. Kalus, U., Koscielny, J., Grigorov, A., Schaefer, E., Peil, H., Kiesewetter, H. Improvement of cutaneous microcirculation and oxygen supply in patients with chronic venous insufficiency by orally administered red vine leaves AS 195: a randomized, double-blind, placebo-controlled, crossover study. Drugs and RD. 5(2):63-71, 2004. https://doi.org/10.2165/00126839-200405020-00001
  18. Jeon, H.Y., Kim, J.K., Kim, W.G., Lee, S.J. Effects of Oral Epigallocatechin Gallate Supplementation on the Minimal Erythema Dose and UV-Induced Skin Damage. Skin Pharmacol Physiol. 22: 137-141, 2009. https://doi.org/10.1159/000201562
  19. Furukawa, F., Kanehara, S., Harano, F., et al. Effects of adenosine 5'-monophosphate on epidermal turnover. Arch Dermatol Res. 300(9):485-493, 2008. https://doi.org/10.1007/s00403-008-0882-x
  20. Karna, E., Miltyk, W., Wolczynski, S., Palka, J.A. The potential mechanism for glutamine-induced collagen biosynthesis in cultured human skin fibroblasts. Comp Biochem Physiol B Biochem Mol Biol. 130(1):23-32, 2001. https://doi.org/10.1016/S1096-4959(01)00400-6
  21. Kang, T.H., Park, H.M., Kim, Y.B., Kim, H., Kim, N., Do, J.H., Kang, C., Cho, Y., Kim, S.Y. Effects of red ginseng extract on UVB irradiation-induced skin aging in hairless mice. J. Ethnopharmacol. 123(3):446-451, 2009. https://doi.org/10.1016/j.jep.2009.03.022