A Case Study of Herbal Medicine-induced Liver Injury Improved with Taeumjowe-tang (Taiyintiaowei-tang)

태음인(太陰人) 약인성 간손상의 태음조위탕(太陰調胃湯) 치험 1례

  • Park, Se-Jung (Department of Sasang Constitutional Medicine, College of Oriental Medicine, Dongeui University) ;
  • Lee, Hyun-Mi (Department of Sasang Constitutional Medicine, College of Oriental Medicine, Dongeui University) ;
  • Kang, Yeon-Kyeong (Department of Oriental Rehabilitation Medicine, College of Oriental Medicine, Dongeui University) ;
  • Jean, Soo-Hyung (Department of Sasang Constitutional Medicine, College of Oriental Medicine, Dongeui University) ;
  • Kim, Jong-Won (Department of Sasang Constitutional Medicine, College of Oriental Medicine, Dongeui University)
  • 박세정 (동의대학교 한의과대학 사상체질과) ;
  • 이현미 (동의대학교 한의과대학 사상체질과) ;
  • 강연경 (동의대학교 한의과대학 재활의학과) ;
  • 전수형 (동의대학교 한의과대학 사상체질과) ;
  • 김종원 (동의대학교 한의과대학 사상체질과)
  • Received : 2010.05.03
  • Accepted : 2010.05.27
  • Published : 2010.06.30

Abstract

1. Objectives: The purpose of this case is to report that a Tae-eumin patient diagnosed as drug-induced liver injury (DILI) caused by Galgeunhaegi-tang (Gegenjieji-tang) treated with Taeumjowe-tang reduced ephedra to 2g (Taiyintiaowei-tang) and then liver function test Results: improved. 2. Methods: We diagnosed him as Tae-eumin Exterior cold disease induced from the esophagus affected by cold. We made him stop taking Galgeunhaegi-tang (Gegenjieji-tang) and take Taeumjowe-tang reduced ephedra to 2g. (Taiyintiaowei-tang) 3. Results: After our treatment, the symptom and the liver function test Results: improved. 4. Conclusions: The wrong diagnosis of constitution and pathological syndromes can be caused drug-induced liver injury. Taeumjowe-tang reduced ephedra to 2g (Taiyintiaowei-tang) may have an effect on treatment of drug-induced liver injury of Tae- eumin.

Keywords

References

  1. Benichou C. Critera of drug-induced liver disorders. J Hepatol. 1990;11:272-276. https://doi.org/10.1016/0168-8278(90)90124-A
  2. 全國韓醫科大學 肝系內科學敎室. 肝系內科學. 4판. 서울시:東洋醫學硏究院. 2001:801-807.
  3. Choi HS, Jeong TY. One case of drug-induced liver injury treated with Saenggangeonbi-tang. Korean J Orient Int Med. 2004;25(4):207-211. (Korean)
  4. Jeong JS, Jeong UM, Lee JS, Yoon SW, Park JW. A case of repetitive drug-induced liver injury treated with Injinchunggan-tang. Korean J Orient Int Med. 2009; fal(1):246-252. (Korean)
  5. Lee KS, Choi KJ, Lee TG, Koh BH, Song IB, Lee SK. A case study of Soeumin jaundice patient diagnosed as drug-induced hepatitis. J Sasang Constitut Med. 2005;17(2):99-106. (Korean)
  6. Moon BH, Kim JG. A case study of hepatitis on drug metabolism improved with Chungsimyeunjatang. J Sasang Constitut Med. 2003;15(1):129-133. (Korean)
  7. Park SM. The Literatural Study on Herbal Medicineinduced Liver Injury. Master's thesis of Wonkwang University. 2007. (Korean)
  8. Yun YJ, Shin BC, Shin WJ, Jang IS. Suggestion of herbal medicine-induced liver injury investigation forms for improving the research quality of herbal safety. Korean J Orient Int Med. 2009;30(1):181-190. (Korean)
  9. An BM. Diagnosis and treatment of drug-induced liver injury. Korean J of Hepatology. 2001;7(1):45-63. (Korean)
  10. 전국한의과대학 사상의학교실. 四象醫學. 2판. 서울시:집문당. 2006:415-416.
  11. 조황성. 四象醫學의原理와方劑. 1판. 파주시: 집문당. 2005:401-402.
  12. Nardir A, Agarwal S, King PD, Marshall JB. Acute hepatitis associated with the use of a chinese herbal product, Ma-huang. Am J Gastroenterol. 1996;91(7): 1436-1438.
  13. Kim MW, Park SS. Effects of Taeumjowetang on lipid peroxidation by free radicals and oxidative damage of hepatocytes by tert-butyl hydroperoxide. J Sasang Constitut Med. 2001;13(1):51-60. (Korean)
  14. An BM. A case study of herbal medicine-induced liver injury. Korean J of Hepatology. 2001;7(3):99-110. (Korean)
  15. Park HM, Jang IS, Lee SD. Hepatotoxic Events Associated with Herbal Medicinal Products, Folk Remedies and Food Supplements in Korea. J Korean Oriental Med. 2005;26(2):152-165. (Korean)
  16. Lee DY, Lee SG, Lee GS, Yang MB. The distribution of AST, ALT in longterm admitted patients after taking herbal medicine. Korean J Orient Int Med. 2002;aut(2):142-148. (Korean)
  17. Rhee SH, Park JS, Yeo HS, Choi YK, Jun CY, Park CH et al. Relationship between herb-medicine and liver damage. Korean J Orient Int Med. 2006;27(3):573-580. (Korean)
  18. Kim TH, Hong SY, Han DN, Lim EC. The effects of constant use of Yeldahanso-tang on liver function. J Sasang Constitut Med. 2007;19(3):217-226. (Korean)
  19. Kim JC, Park HM, Cho HS, Park JH, Lee JE, Song CH et al. Comparison of liver function test score by herbal medication duration. J Orient Int Med. 2005; aut(1):37-45. (Korean)