Journal of Preventive Medicine and Public Health

The Korean Society for Preventive Medicine (대한예방의학회)
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Cigarette Smoking and Mortality in the Korean Multi-center Cancer Cohort (KMCC) Study

한국인의 흡연과 사망 위험에 관한 코호트 연구

  • Lee, Eun-Ha (Department of Preventive Medicine, Seoul National University College of Medicine) ;
  • Park, Sue-K. (Department of Preventive Medicine, Seoul National University College of Medicine) ;
  • Ko, Kwang-Pil (Korea Centers for Disease Control and Prevention) ;
  • Cho, In-Seong (Department of Preventive Medicine, Seoul National University College of Medicine) ;
  • Chang, Soung-Hoon (Department of Preventive Medicine, Konkuk University) ;
  • Shin, Hai-Rim (National Cancer Control Research Institute, National Cancer Center) ;
  • Kang, Dae-Hee (Department of Preventive Medicine, Seoul National University College of Medicine) ;
  • Yoo, Keun-Young (Department of Preventive Medicine, Seoul National University College of Medicine)
  • 이은하 (서울대학교 의과대학 예방의학교실) ;
  • 박수경 (서울대학교 의과대학 예방의학교실) ;
  • 고광필 (질병관리본부) ;
  • 조인성 (서울대학교 의과대학 예방의학교실) ;
  • 장성훈 (건국대학교 의과대학 예방의학교실) ;
  • 신해림 (국립암센터) ;
  • 강대희 (서울대학교 의과대학 예방의학교실) ;
  • 유근영 (서울대학교 의과대학 예방의학교실)
  • Received : 2009.06.30
  • Accepted : 2009.10.29
  • Published : 2010.03.31
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Abstract

Objectives: The aim of this study was to evaluate the association between cigarette smoking and total mortality, cancer mortality and other disease mortalities in Korean adults. Methods: A total of 14 161 subjects of the Korean Multi-center Cancer Cohort who were over 40 years of age and who were cancer-free at baseline enrollment reported their lifestyle factors, including the smoking status. The median follow-up time was 6.6 years. During the follow-up period from 1993 to 2005, we identified 1159 cases of mortality, including 260 cancer mortality cases with a total of 91 987 person-years, by the national death certificate. Cox proportional hazard regression model was used to estimate the hazard ratio (HR) of cigarette smoking for total mortality, cancer mortality and disease-specific mortality, as adjusted for age, gender, the geographic area and year of enrollment, the alcohol consumption status, the education level and the body mass index (BMI). Results: Cigarette smoking was significantly associated with an increased risk of total mortality, all-cancer mortality and lung cancer mortality (p-trend, < 0.01, <0.01, <0.01, respectively). Compared to non-smoking, current smokers were at a higher risk for mortality [HR (95% CI)=1.3 (1.1 - 1.5) for total mortality; HR (95% CI)=1.6 (1.1 -2.2) for all-cancer mortality; HR (95% CI)=3.9 (1.9-7.7) for lung cancer mortality]. Conclusions: This study's results suggest that cigarette smoking might be associated with total mortality, all-cancer mortality and especially lung cancer mortality among Korean adults.

Keywords

References

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