Journal of Preventive Medicine and Public Health

The Korean Society for Preventive Medicine (대한예방의학회)
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The Association Between Apolipoprotein E Genotype and Lipid Profiles in Healthy Woman Workers

건강한 여성 근로자에서 Apolipoprotein E와 혈중 지질 농도와의 관련성

  • Moon, Gi-Eun (Division of Health Management, Radiation Health Research Institute, Korea Hydro & Nuclear Power Co., LTD.) ;
  • Sung, Sook-Hee (Division of Health Management, Radiation Health Research Institute, Korea Hydro & Nuclear Power Co., LTD.) ;
  • Chang, Youn-Koun (Division of Health Management, Radiation Health Research Institute, Korea Hydro & Nuclear Power Co., LTD.) ;
  • Park, Il-Keun (Division of Health Management, Radiation Health Research Institute, Korea Hydro & Nuclear Power Co., LTD.) ;
  • Paek, Yun-Mi (Division of Health Management, Radiation Health Research Institute, Korea Hydro & Nuclear Power Co., LTD.) ;
  • Kim, Soo-Geun (Department of Occupational Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University, School of Medicine) ;
  • Choi, Tae-In (Division of Health Management, Radiation Health Research Institute, Korea Hydro & Nuclear Power Co., LTD.) ;
  • Jin, Young-Woo (Division of Radiation Effect Research, Radiation Health Research Institute, Korea Hydro )
  • 문기은 (한국수력원자력(주) 방사선보건연구원 건강관리팀) ;
  • 성숙희 (한국수력원자력(주) 방사선보건연구원 건강관리팀) ;
  • 장윤균 (한국수력원자력(주) 방사선보건연구원 건강관리팀) ;
  • 박일근 (한국수력원자력(주) 방사선보건연구원 건강관리팀) ;
  • 백윤미 (한국수력원자력(주) 방사선보건연구원 건강관리팀) ;
  • 김수근 (성균관대학교 의과대학 산업의학교실, 강북삼성병원 산업의학과) ;
  • 최태인 (한국수력원자력(주) 방사선보건연구원 건강관리팀) ;
  • 진영우 (한국수력원자력(주) 방사선보건연구원 방사선영향연구팀)
  • Received : 2009.09.28
  • Accepted : 2009.12.11
  • Published : 2010.05.31
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Abstract

Objectives: Plasma lipid profiles and Apolipoprotein E (ApoE) are established risk factors for cardiovascular disease (CVD). The knowledge of lipid profile may estimate the potential victims of cardiovascular disease before its initiation and progression and offers the opportunity for primary prevention. The most common ApoE polymorphism has been found to influence plasma lipid concentrations and its correlation with CVD has been extensively investigated in the last decade. Methods: The ApoE polymorphism and its influence on plasma lipid were investigated in healthy woman workers. The information on confounding factors was obtained through a self-administered questionnaire and ApoE polymorphism was investigated using PCR. Results: The relative frequencies of alleles E2, E3 and E4 for the study population (n = 305) were 0.127, 0.750 and 0.121, respectively. ApoE polymorphism was associated with variations in plasma HDL-cholesterol lipid profile. In order to estimate the independent effects of alleles E2 and E4, as compared with E3, on lipid profile, multiple regression was performed after adjustment for confounding variables such as age, BMI, blood pressure, education status, insulin, fasting glucose, HOMA-IR, menopause. ApoE2 had a negative association with HDL cholesterol and ApoE4 had a positive association with LDL cholesterol. Conclusions: This study identified that the ApoE and CVD risk factors contribute to the lipid profiles, similar to other studies. The analysis including dietary intake and other gene in further studies may help to identify clear effects on lipid profiles as risk factor for CVD.

Keywords

References

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