Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
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Application of Silver Ion for Clinical Mastitis in Holstein Cows

임상형 유방염을 가진 홀스테인(Holstein) 소에 대한 은 이온의 적용 연구

  • Seol, Jae-Won (Center for Healthcare Technology Development, Bio-Safety Research Institute, College of Veterinary Medicine, Chonbuk National University) ;
  • Hur, Tai-Young (National Institute of Animal Science, Rural Development Administration) ;
  • Jung, Young-Hun (National Institute of Animal Science, Rural Development Administration) ;
  • Park, Sang-Youel (Center for Healthcare Technology Development, Bio-Safety Research Institute, College of Veterinary Medicine, Chonbuk National University) ;
  • Kang, Seog-Jin (National Institute of Animal Science, Rural Development Administration)
  • 설재원 (헬스케어 기술개발 사업단, 전북대학교 수의과대학 생체안전성 연구소) ;
  • 허태영 (농촌진흥청 국립축산과학원) ;
  • 정영훈 (농촌진흥청 국립축산과학원) ;
  • 박상열 (헬스케어 기술개발 사업단, 전북대학교 수의과대학 생체안전성 연구소) ;
  • 강석진 (농촌진흥청 국립축산과학원)
  • Accepted : 2010.04.12
  • Published : 2010.06.30
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Abstract

Mastitis is an inflammation of the mammary gland that develops as a response to pathogenic microorganisms. Somatic cell count (SCC) and bacteriological analysis are the most accepted tools to determine udder health. This study evaluated the effects of intra-mammary gland infusion of silver ion against clinical mastitis in Holstein cows. Silver ion (20 ${\mu}g$/ml) was infused through the intra-mammary gland in quarters having clinical mastitis and milk was collected to determine SCC, and levels of lactoferrin and bovine serum albumin (BSA). Silver ion infusion decreased udder inflammation, firmness and swelling, and reduced clots, BSA, lactoferrin and SCC in milk. However, milk yield and circulating blood cells remained unchanged. The silver ion-mediated reductions of BSA and SCC indicate reduced inflammation and bacterial activity in silver ion-treated mammary glands in Holsteins with mastitis, which may be exploited in a curative strategy.

유방염은 병원성 미생물들에 의한 유선 내에 염증이 생기는 질환으로, 유방 조직과 우유 내 체세포수 (SCC)와 세균학적 분석이 유방염 진단을 위해서 사용된다. 본 연구에서는 임상형 유방염이 걸린 홀스테인 소의 유선 내로 은 이온(20 ${\mu}g$/ml)을 투입하고, 유방염의 임상 증상의 변화와 우유 내 somatic cell count, 소 혈청 알부민과 lactoferrin 등과 같은 유방염 관련 인자들을 조사하였다. 은 이온의 유선 내 투입은 유방의 부종과 견고함 등의 염증 증상을 완화시켰으며, 우유의 응고와 체세포수를 감소시켰다. 또한, 우유 내 소 혈청 알부민과 lactoferrin의 농도가 은 이온의 투입에 의해 감소되었다, 그러나 임상형 유방염이 걸린 소의 유선 내 은 이온의 투입은 착유된 우유의 양과 혈액 내 백혈구와 적혈구 수를 변화시키지는 않았다. 이러한 결과는 유방염이 걸린 소에 은 이온을 유선 내로 투입 함으로서 염증과 세균의 활성을 감소시킨다는 것을 보여주며, 은 이온을 임상형 유방염의 치료에 적용할 수 있는 가능성을 보여 주는 것이다.

Keywords

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