Journal of Acupuncture Research

Korean Acupuncture & Moxibustion Medicine Society (대한침구의학회)
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Duration Pattern of the Effect of Acupuncture at $HT_7$ in Morphine Self-administration

모르핀 자가투여에서 신문혈 자침효과의 지속 양상

  • Lee, Bong-Hyo (Dept. of Acupuncture, Moxibustion, Meridian, & Acupoint, College of Oriental Medicine, Daegu Haany University) ;
  • Park, Seo-Young (Dept. of Acupuncture, Moxibustion, Meridian, & Acupoint, College of Oriental Medicine, Daegu Haany University) ;
  • Lee, Ji-Hye (Dept. of Acupuncture, Moxibustion, Meridian, & Acupoint, College of Oriental Medicine, Daegu Haany University) ;
  • Lim, Sung-Chul (Dept. of Acupuncture, Moxibustion, Meridian, & Acupoint, College of Oriental Medicine, Daegu Haany University) ;
  • Kim, Jae-Su (Dept. of Acupuncture, Moxibustion, Meridian, & Acupoint, College of Oriental Medicine, Daegu Haany University) ;
  • Lee, Yun-Kyu (Dept. of Acupuncture, Moxibustion, Meridian, & Acupoint, College of Oriental Medicine, Daegu Haany University) ;
  • Jung, Tae-Young (Dept. of Diagnostics, College of Oriental Medicine, Daegu Haany University) ;
  • Yang, Chae-Ha (Dept. of Physiology, College of Oriental Medicine, Daegu Haany University) ;
  • Yoon, Seong-Shoon (Dept. of Physiology, College of Oriental Medicine, Daegu Haany University) ;
  • Lee, Kyung-Min (Dept. of Acupuncture, Moxibustion, Meridian, & Acupoint, College of Oriental Medicine, Daegu Haany University)
  • 이봉효 (대구한의대학교 한의과대학 침구경락경혈학교실) ;
  • 박서영 (대구한의대학교 한의과대학 침구경락경혈학교실) ;
  • 이지혜 (대구한의대학교 한의과대학 침구경락경혈학교실) ;
  • 임성철 (대구한의대학교 한의과대학 침구경락경혈학교실) ;
  • 김재수 (대구한의대학교 한의과대학 침구경락경혈학교실) ;
  • 이윤규 (대구한의대학교 한의과대학 침구경락경혈학교실) ;
  • 정태영 (대구한의대학교 한의과대학 진단학교실) ;
  • 양재하 (대구한의과대학 한의과대학 생리학교실) ;
  • 윤성순 (대구한의과대학 한의과대학 생리학교실) ;
  • 이경민 (대구한의대학교 한의과대학 침구경락경혈학교실)
  • Received : 2010.06.28
  • Accepted : 2010.07.19
  • Published : 2010.08.20
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Abstract

목적 : 기존 연구에서 신문혈 자침은 알코올 및 코카인을 자가섭취하는 동물 모델에서 효과적이라는 점이 밝혀졌으며, 또한 모르핀 자가섭취를 억제할 수 있음이 밝혀졌다. 이러한 결과를 바탕으로 본 연구에서는 자침의 효과가 얼마나 지속될 수 있는지 알아보았다. 재료 및 방법 : 체중 270~300g의 수컷 SD계 흰쥐를 이용하였다. 먹이섭취 훈련을 통과한 후 오른쪽 경정맥에 관을 삽입하는 수술을 거쳐, 0.1mg/kg의 모르핀을 매일 1시간, 총 3주 동안 자가섭취 하도록 하였다. 모르핀을 일정하게 섭취한 동물에게는 다음날 침술을 시행하였다. 두 번째 실험에서는 GABAA 및 GABAB 길항제를 자침 30분 전에 투여하여 침술의 효능과 GABA 수용체계 사이의 관계를 검증하였다. 결과 : 모르핀 자가섭취를 억제하는 신문혈 자침의 효과는 매일 비슷하게 나타나지 않았으며, 4일째에는 유의한 효과가 없는 것으로 나타났다. 그러나 5일째와 6일째에는 다시 유의한 효과가 나타나 뒤집어진 U 자형 곡선을 나타내었다. 또한 GABA 수용체의 길항제들은 자침의 효과가 유의하게 나타났을 때 이를 차단하는 결과를 보였다. 결론 : 모르핀 중독 치료에서 침술의 효과는 항상 비슷하게 발휘되는 것이 아니므로 침 치료는 적어도 1주일에 2회 이상 받을 필요가 있다. 아울러 보다 심도 있는 연구를 위하여 뇌신경 체계에 대한 연구가 이루어질 필요가 있는 것으로 사료된다.

Keywords

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