The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
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Thirteen-week repeated-dose oral toxicity study of the Modified Wenpitang-Hab-Wulingsan (WHW$^{(R)}$) in Sprague-Dawley rats

WHW$^{(R)}$의 랫드에서의 반복경구투여 독성에 관한 연구

  • Oh, Tae-Woo (Department of Herbology, College of Oriental Medicine, Dongguk University) ;
  • Sang, Bae-Hyo (Department of Sassang Constitunal Medicine, Dongguk University Ilsan Oriental Hospital) ;
  • Yoon, Cheol-Ho (Department of Internal Medicine, Orient Medical College, Dongguk University Bundang Oriental Hospital) ;
  • Park, Yong-Ki (Department of Herbology, College of Oriental Medicine, Dongguk University)
  • 오태우 (동국대학교 한의과대학 본초학교실) ;
  • 배효상 (동국대학교부속 일산한방병원 사상체질과) ;
  • 윤철호 (동국대학교 분당한방병원) ;
  • 박용기 (동국대학교 한의과대학 본초학교실)
  • Received : 2010.08.06
  • Accepted : 2010.09.13
  • Published : 2010.09.30
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Abstract

Objectives : We investigated the repeated-dose toxicity of Wenpitang-Hab-Wulingsan(WHW), a Korean traditional medicine prescribed with twelve herbs, which has been used for the treatment of renal disease. Methods : WHW extract prepared by GLP company. WHW was supplemented by gavage at 0, 100, 500 and 1000 mg/kg/day for 13-week consecutive days. We recorded the clinical signs of toxicity, body weight, organ weights, hematology, gross and histological changes in target organs rats and clinical chemistry analysis for all rats. Results : WHW extract at all doses was shown no mortality or abnormal clinical signs in rats during at the observation period. Furthermore, there was no difference in body weight and food-take consumption, organ weight, gross pathological findings, and urine analysis among the groups of rats treated with different doses of WHW extract. The hematological analysis and clinical blood chemistry data were revealed no toxic effects from WHW-treated rats. Conclusions : The results suggest that WHW extract in rats is a wide margin of safety on a acute toxicity.

Keywords

References

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