The Journal of the Acoustical Society of Korea

The Acoustical Society of Korea (한국음향학회)
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High Intensity Focused Ultrasound for Cancer Treatment: Current Agenda and the Latest Technology Trends

HIFU: 현황 및 기술적 동향

  • Seo, Jong-Bum (Department of Biomedical Engineering, Yonsei University)
  • Received : 2010.04.09
  • Accepted : 2010.06.09
  • Published : 2010.06.30
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Abstract

High Intensity Focused Ultrasound (HIFU) is a noninvasive surgical method mainly targeting deeply located cancer tissue. Ultrasound is generated from an extemally located transducer and the beam is focused at the target volume, so that selective damage can be achieved without harm to overlying or surrounding tissues. The mechanism for cell killing can be combination of thermal and cavitational damage. Although cavitation can be an effective means of tissue destruction, the possibility of massive hemorrhage and the unpredictable nature of cavitational events prevent clinical application of cavitation. Hence, thermal damage has been a main focus related to HIFU research. 2D phased array transducer systems allow electronic scanning of focus, multi-foci, and anti-focus with multi-foci, so that HIFU becomes more applicable in clinical use. Currently, lack of noninvasive monitoring means of HIFU is the main factor to limit clinical applications, but development in MRI and Ultrasound Imaging techniques may be able to provide solutions to overcome this problem. With the development of advanced focusing algorithm and monitoring means, complete noninvasive surgery is expected to be implemented in the near future.

Keywords

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