Investigative and Clinical Urology

The Korean Urological Association (대한비뇨의학회)
권호 표지
DOI QR코드

DOI QR Code

Sarcomatoid Carcinoma of the Urinary Bladder: A Clinicopathological Study of 4 Cases and a Review of the Literature

  • Received : 2010.05.24
  • Accepted : 2010.07.13
  • Published : 2010.10.22
⟨ Previous Next ⟩

Abstract

Sarcomatoid carcinoma (SC) of urinary bladder is a rare tumor exhibiting aggressive behavior. Here we are reviewing the pathologic and clinical characteristics of 4 consecutive cases of this rare tumor. Three out of 4 patients were males and one female. The median age was 72.8 years (range, 60-79 years). Patients underwent transurethral resection of bladder tumor and the diagnosis of bladder SC was established on the pathologic examination of the resected bladder tissue. Despite treatment all patients died within 22 months of the diagnosis of SC. SC of the bladder are true biphasic malignant neoplasm exhibiting morphologic and immunohistochemical evidence of epithelial and mesenchymal differentiation with the presence or absence of heterologous elements. The aggressive of the tumor precludes radical therapy whenever possible, since adjuvant therapy seems to have little effect.

Keywords

References

  1. Eble JN, Sauter G, Epstein JI. World Health Organization Classification of tumors: pathology and genetics of tumors of the urinary system and male genital organs. Lyon: IARC Press; 2004;99-133.
  2. Lopez-Beltran A, Pacelli A, Rothenberg HJ, Wollan PC, Zincke H, Blute ML, et al. Carcinosarcoma and sarcomatoid carcinoma of the bladder: clinicopathological study of 41 cases. J Urol 1998;159:1497-503. https://doi.org/10.1097/00005392-199805000-00023
  3. Wick MR, Swanson PE. Carcinosarcomas: current perspectives and an historical review of nosological concepts. Semin Diagn Pathol 1993;10:118-27.
  4. Young RH. Spindle cell lesions of the urinary bladder. Histol Histopathol 1990;5:505-12.
  5. Holtz F, Fox JE, Abell MR. Carcinosarcoma of the urinary bladder. Cancer 1972;29:294-304. https://doi.org/10.1002/1097-0142(197202)29:2<294::AID-CNCR2820290205>3.0.CO;2-V
  6. Sung MT, Wang M, McLennan GT, Eble JN, Tan PH, Lopez- Beltran A, et al. Histogenesis of sarcomatoid urothelial carcinoma of the urinary bladder: evidence for a common clonal origin with divergent differentiation. J Pathol 2007;211:420-30. https://doi.org/10.1002/path.2129
  7. Hosokawa Y, Kuwada M, Kumamoto H, Hayashi Y, Fujimoto K, Hirao Y. Case of sarcomatoid carcinoma of the urinary bladder. Hinyokika Kiyo 2008;54:561-3.
  8. Kang SG, Yoon CY, Cho JH, Yoon DK, Kim IS. Sarcomatoid carcinoma of the renal pelvis. Korean J Urol 2005;46:651-4.
  9. Jeong YB, Park SC, Park JK, Kim HJ, Moon WS. A case of sarcomatoid carcinoma of the bladder. Korean J Urol 1999;40:252-5.
  10. Onal C, Pehlivan B, Bal N, Topkan E, Kilinc F, Topuk S. Sarcomatoid carcinoma of the urinary bladder treated with adjuvant radiotherapy: a case report. Clin Med 2009;12:39-42.

Cited by

  1. Early Detection and Gemcitabine/Cisplatin Combination Positively Effect Survival in Sarcomatoid Carcinoma of the Urinary Bladder vol.13, pp.11, 2010, https://doi.org/10.7314/apjcp.2012.13.11.5729
  2. Sarcomatoid Carcinoma of Male Urethra with Bone and Lung Metastases Presenting as Urethral Stricture vol.2013, pp.None, 2013, https://doi.org/10.1155/2013/931893
  3. Extensive rhabdomyosarcomatous differentiation in recurrent low-grade urothelial carcinoma of the bladder after transurethral resection: a case report vol.9, pp.1, 2010, https://doi.org/10.1186/s13256-015-0684-7
  4. Characteristics and clinical significance of histological variants of bladder cancer vol.14, pp.11, 2010, https://doi.org/10.1038/nrurol.2017.125
  5. A Case of Early Stage Bladder Carcinosarcoma in Late Recurrence of Urothelial Carcinoma after Transurethral Resection vol.2018, pp.None, 2010, https://doi.org/10.1155/2018/1405108
  6. First report on establishment and characterization of a carcinosarcoma tumour cell line model of the bladder vol.11, pp.1, 2021, https://doi.org/10.1038/s41598-021-85400-5