Korean journal of dermatology (대한피부과학회지)

Korean Dermatological Association (대한피부과학회)
권호 표지

The Therapeutic Efficacy of the Moisturizer APDDR-0801 for Patients with Atopic Dermatitis

아토피피부염 환자에서 APDDR-0801 보습 제품의 치료 효능

  • Park, Ju-Hee (Department of Dermatology, Chung-Ang University College of Medicine) ;
  • Lee, Kwang-Hoon (Department of Dermatology, Severance Hospital, Yonsei University College of Medicine) ;
  • Kim, Jin-Wou (Department of Dermatology, Uijeongbu St. Mary's Hospital, The Catholic University of Korea College of Medicine) ;
  • Ro, Young-Suck (Department of Dermatology, Hanyang University College of Medicine) ;
  • Park, Cheon-Wook (Department of Dermatology, Kangnam Sacred Heart Hospital, Hallym University College of Medicine) ;
  • Park, Won-Seok (AmorePacific R&D Center) ;
  • Koh, Hyun-Ju (AmorePacific R&D Center) ;
  • Kim, Jeong-Hwan (AmorePacific R&D Center) ;
  • Seo, Seong-Jun (Department of Dermatology, Chung-Ang University College of Medicine)
  • 박주희 (중앙대학교 의과대학 피부과학교실) ;
  • 이광훈 (연세대학교 의과대학 신촌세브란스병원 피부과학교실) ;
  • 김진우 (가톨릭대학교 의과대학 의정부성모병원 피부과학교실) ;
  • 노영석 (한양대학교 의과대학 피부과학교실) ;
  • 박천욱 (한림대학교 의과대학 강남성심병원 피부과학교실) ;
  • 박원석 (아모레퍼시픽 기술연구원) ;
  • 고현주 (아모레퍼시픽 기술연구원) ;
  • 김정환 (아모레퍼시픽 기술연구원) ;
  • 서성준 (중앙대학교 의과대학 피부과학교실)
  • Received : 2009.12.28
  • Accepted : 2010.01.25
  • Published : 2010.02.28
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Abstract

Background: The patients with atopic dermatitis (AD) show a defective barrier function of the skin and symptoms such as xerosis, pruritus and erythematous lesions with increased transepidermal water loss (TEWL). The choice of topical moisturizer is very significant for AD patients because these symptoms could be relieved by a local moisturizing agent that strengthens the epidermal barrier function. Objective: This study was performed to evaluate the effects of the moisturizer APDDR-0801, which contains physiologic lipid granules ($DermaON^{(R)}$), for relieving the symptoms associated with AD. Methods: 128 patients ($17.8{\pm}12.1$ years) who were suffering from mild to moderate AD topically applied the test moisturizer twice daily for up to 4 weeks. The treatment efficacy was evaluated by the investigator global assessment (IGA) score, the eczema area and severity index (EASI) score, the transepidermal water loss (TEWL), the visual analogue scale (VAS) for pruritus and sleep disturbance, and the level of inflammatory cytokines in the horny layer of the flexural areas. Results: The test moisturizer was well-tolerated and 58.6% of the patients achieved clinical improvements (over moderate) after the application of the test moisturizer for 4 weeks. The significant relief of AD symptoms was observed from 2 week to 4 week in a time-dependent manner. Significant improvements in the signs and symptoms of AD were observed at 4 week, such as the EASI score (37.8% improvement), the TEWL (20.3% improvement in the antecubital fossa lesion), the VAS score for pruritus (26.2% improvement), and VAS score for insomnia (39.7% improvement). Conclusion: The moisturizer APDDR-0801 (Atobarrier $Cream^{(R)}$, which contains physiologic lipid granules, effectively relieved the symptoms associated with AD.

Keywords

References

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