Korean journal of dermatology (대한피부과학회지)

Korean Dermatological Association (대한피부과학회)
권호 표지

Effects of Alcohol Intake on the Skin Physiology

알코올 섭취가 피부 생리에 미치는 영향

  • Jang, Woo-Sun (Department of Dermatology, Chung-Ang University Colleage of Medicine) ;
  • Kim, Chan-Woong (Department of Emergency Medicine, Chung-Ang University Colleage of Medicine) ;
  • Kim, Sung-Eun (Department of Emergency Medicine, Chung-Ang University Colleage of Medicine) ;
  • Kim, Beom-Joon (Department of Dermatology, Chung-Ang University Colleage of Medicine) ;
  • Kim, Myeung-Nam (Department of Dermatology, Chung-Ang University Colleage of Medicine)
  • 장우선 (중앙대학교 의과대학 피부과학교실) ;
  • 김찬웅 (중앙대학교 의과대학 응급의학교실) ;
  • 김성은 (중앙대학교 의과대학 응급의학교실) ;
  • 김범준 (중앙대학교 의과대학 피부과학교실) ;
  • 김명남 (중앙대학교 의과대학 피부과학교실)
  • Received : 2010.07.19
  • Accepted : 2010.10.19
  • Published : 2010.11.30
⟨ Previous Next ⟩

Abstract

Background: Alcohol intake induces complex changes in the human body. However, there has not been much investigation on the interaction between alcohol and human skin. Objective: The aim of this study is to investigate the effects of alcohol intake on the skin's physiology. Methods: A total 16 Korean males was enrolled in this study and they were divided into two groups (group A and group B). Each group included 8 people. Group A drank alcohol (20.1%, 360 ml) for 90 min and Group B drank 360 ml of normal saline. The body temperature, the skin erythema index, the transepidermal water loss (TEWL), the skin hydration, the skin pH and skin sebum were measured before and 30 min and 120 min after alcohol intake. Results: In group A, the skin erythema index, TEWL, skin hydration and skin pH significantly increased 30 min after alcohol intake, while the body temperature and sebum decreased. All the measurements except sebum recovered 120 min after alcohol intake. However, in group B, all the measurements were not significantly changed. Conclusion: Alcohol intake affects thermoregulation, the skin barrier function and the skin pH. This study showing that physiologic changes are induced by alcohol intake may help investigate the interaction between alcohol and skin disease.

Keywords

References

  1. Higgins EM, du Vivier AW. Alcohol and the skin. Alcohol Alcohol 1992;27:595-602
  2. Yoda T, Crawshaw LI, Nakamura M, Saito K, Konishi A, Nagashima K, et al. Effects of alcohol on thermoregulation during mild heat exposure in humans. Alcohol 2005;36:195-200 https://doi.org/10.1016/j.alcohol.2005.09.002
  3. Yoda T, Crawshaw LI, Saito K, Nakamura M, Nagashima K, Kanosue K. Effects of alcohol on autonomic responses and thermal sensation during cold exposure in humans. Alcohol 2008;42:207-212 https://doi.org/10.1016/j.alcohol.2008.01.006
  4. Jacobi U, Bartoll J, Sterry W, Lademann J. Orally administered ethanol: transepidermal pathways and effects on the human skin barrier. Arch Dermatol Res 2005;296:332-338 https://doi.org/10.1007/s00403-004-0526-8
  5. Brand RM, Jendrzejewski JL, Charron AR. Potential mechanisms by which a single drink of alcohol can increase transdermal absorption of topically applied chemicals. Toxicology 2007;235:141-149 https://doi.org/10.1016/j.tox.2007.03.008
  6. Pinnagoda J, Tupker RA, Coenraads PJ, Nater JP. Transepidermal water loss with and without sweat gland inactivation. Contact Dermatitis 1989;21:16-22 https://doi.org/10.1111/j.1600-0536.1989.tb04679.x
  7. Ahn SW, Kim YJ, Kim BJ, Kim MN, Lee DH, Huh CH. Comparative study of 20% aluminum chloride solution and botulinum toxin a injection in the treatment of patients with primary palmar hyperhidrosis. Korean J Dermatol 2008;46:334-340
  8. Schmid-Wendtner MH, Korting HC. The pH of the skin surface and its impact on the barrier function. Skin Pharmacol Physiol 2006;19:296-302 https://doi.org/10.1159/000094670
  9. Parra JL, Paye M. EEMCO guidance for the in vivo assessment of skin surface pH. Skin Pharmacol Appl Skin Physiol 2003;16:188-202 https://doi.org/10.1159/000069756
  10. Higgins E, du Vivier A. Alcohol intake and other skin disorders. Clin Dermatol 1999;17:437-441 https://doi.org/10.1016/S0738-081X(99)00038-3
  11. Freedman DM, Sigurdson A, Doody MM, Mabuchi K, Linet MS. Risk of basal cell carcinoma in relation to alcohol intake and smoking. Cancer Epidemiol Biomarkers Prev 2003;12:1540-1543
  12. Freedman DM, Sigurdson A, Doody MM, Rao RS, Linet MS. Risk of melanoma in relation to smoking, alcohol intake, and other factors in a large occupational cohort. Cancer Causes Control 2003;14:847-857
  13. Brand RM, Jendrzejewski JL. Chronic ethanol ingestion alters xenobiotic absorption through the skin: potential role of oxidative stress. Food Chem Toxicol 2008;46:1940-1948 https://doi.org/10.1016/j.fct.2008.01.034