Psychiatry investigation

Korean Neuropsychiatric Association (대한신경정신의학회)
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Gender-Specific Association of the Brain-Derived Neurotrophic Factor Gene with Attention-Deficit/Hyperactivity Disorder

  • Cho, Soo-Churl (Department of Child and Adolescent Psychiatry, Seoul National University College of Medicine) ;
  • Kim, Hyo-Won (Department of Child and Adolescent Psychiatry, Seoul National University College of Medicine) ;
  • Kim, Boong-Nyun (Department of Child and Adolescent Psychiatry, Seoul National University College of Medicine) ;
  • Kim, Jae-Won (Department of Child and Adolescent Psychiatry, Seoul National University College of Medicine) ;
  • Shin, Min-Sup (Department of Child and Adolescent Psychiatry, Seoul National University College of Medicine) ;
  • Chung, Seock-Hoon (Department of Psychiatry, University of Ulsan College of Medicine, Asan Medical Center) ;
  • Cho, Dae-Yeon (LabGenomics Clinical Research Institute) ;
  • Jung, Sun-Woo (Department of Child and Adolescent Psychiatry, Seoul National University College of Medicine) ;
  • Yoo, Hee-Jeong (Department of Psychiatry, Seoul National University Bundang Hospital) ;
  • Chung, In-Won (Department of Neuropsychiatry, Dongguk University College of Medicine) ;
  • Chung, Un-Sun (Department of Psychiatry, Kyungpook National University College of Medicine) ;
  • Son, Jung-Woo (Department of Psychiatry, Chungbuk National University College of Medicine)
  • Received : 2010.05.10
  • Accepted : 2010.09.15
  • Published : 2010.12.30
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Abstract

Objective Attention-deficit/hyperactivity disorder (ADHD) is a complex neurodevelopmental disorder with a strong genetic component. Brain-derived neurotrophic factor (BDNF), which participates in the differentiation and survival of dopaminergic and noradrenergic neurons, could play a role in ADHD development. We aimed to explore the relationships between ADHD and BDNF gene polymorphism. Methods We conducted a case-control analysis of 202 ADHD subjects and 159 controls, performed a transmission disequilibrium test on 151 trios, and compared the results of a continuous performance test (CPT) according to the genotype of the three single nucleotide polymorphisms (rs11030101, rs6265, rs16917204) in the BDNF gene. Results In the case-control analysis, the AA genotype of the BDNF rs11030101 polymorphism was significantly associated with ADHD only in girls (p=0.024, odds ratio=3.00). The T-G-G haplotype was significantly less frequent (p=0.005) and A-G-G was more frequent (p=0.048) in girls with ADHD than in control girls (global p=0.027). A multivariate analysis of variance for commission errors on the CPT showed a significant main effect for the rs11030101 genotype (p=0.026) and an interaction effect of the rs11030101 genotype and gender (p=0.032) in ADHD probands. Conclusion These results provide preliminary evidence for a gender-specific association between BDNF and ADHD in the Korean population.

Keywords

Acknowledgement

Supported by : Neuropsychiatry Research Foundation

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