Journal of Applied Biological Chemistry

The Korean Society for Applied Biological Chemistry (한국응용생명화학회)
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Synthesis of Salens and Their Cobalt Complexes from Meso-1,2-Diamine and Their Anti-Cancer Property

메소-1,2-디아민을 이용한 Salen-코발트 착화합물의 합성과 항암효과

  • Koh, Dong-Soo (Department of Applied Chemistry, Dongduk Women's University)
  • 고동수 (동덕여자대학교 응용화학과)
  • Received : 2010.03.22
  • Accepted : 2010.04.21
  • Published : 2010.06.30
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Abstract

New salens (3) and their Cobalt complexes (4) were prepared from meso-1,2-bis(ortho-hydroxyphenyl)-1,2-diaminoethane (1) and substituted salicylic aldehydes (2). In contrast to symmetric structure of salen ligand (3), salen-Co(III) complexes (4) showed dissymmetric molecular structure due to participation of three hydroxyl groups in complex formation. One of the salens (3b) revealed decrease in Cyclin D1 expression, which represents anti-cancer property.

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References

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