Atopy and Sensitization Rates to Aeroallergens in Children and Teenagers in Jeju, Korea

제주 소아 및 청소년의 아토피 및 흡입 알레르기항원에 대한 감작률

  • 전봉희 (제주대학교병원, 제주대학교 의학전문대학원) ;
  • 이재천 (제주대학교병원, 제주대학교 의학전문대학원) ;
  • 김정홍 (제주대학교병원, 제주대학교 의학전문대학원) ;
  • 김재왕 (제주대학교병원, 제주대학교 의학전문대학원) ;
  • 이혜숙 (환경보건센터) ;
  • 이근화 (환경보건센터)
  • Received : 2009.04.04
  • Accepted : 2010.02.07
  • Published : 2010.03.25

Abstract

Background: Atopic sensitization to aeroallergens is an essential preceding factor for atopic disorders. The information on the sensitization rates and their changes is an important tool to cope with increasing atopic disorders; however, it is rarely available in Korea. Objective: We investigated the prevalence of atopy, the sensitization rates to common aeroallergens and their recent changes. Method: With informed consent, skin prick tests were performed on the study population. Atopy was defined as that one or more positive skin prick test responses (wheal, ${\geq}3\;mm$) to the 16 common aeroallergens. The prevalence of atopy and the sensitization rates to each allergen were compared with those of previous reports. Result: Approximately 7% (1,343, mean age of 13 years) of school children in Jeju were enrolled. Skin tests to the 16 aeroallergens were performed on 1,060 subjects (83%). The prevalence of atopy was 51.9%. House dust mites (HDM), Japanese cedar, Tyrophagus putrescentiae and citrus red mites were frequently sensitized aeroallergens. Comparing with previous reports, the prevalence of atopy and the sensitization rates of HDM, cedar and outdoor moulds were higher. Conclusion: Atopy among school children in Jeju is increasing. HDM, Japanese cedar and outdoor moulds are the important aeroallergens which are increasing recently. The increase of atopic disorder may be related to the change of living environment.

Keywords

References

  1. Adkinson NF: In vivo methods for study of allergy: skin tests, techniques, and interpretation, In Middleton's Allergy (ed.): Principles & practice. 6th ed. p 631-43, Mosby, Philadelphia, 2005
  2. Wood RA, Phipatanakul W, Hamilton RG, Eggleston PA. A comparison of skin prick tests, intradermal skin tests, and RASTs in the diagnosis of cat allergy. J Allergy Clin Immunol 1999;103: 773-9 https://doi.org/10.1016/S0091-6749(99)70419-7
  3. Hong CS. Allergic skin test and reading method. J Asthma Allergy Clin Immunol 1993;13:23-32
  4. Beasley R, Crane J, Lai CKW, Pearce N. Prevalence and etiology of asthma. J Allergy Clin Immunol 2000;105:466-72 https://doi.org/10.1016/S0091-6749(00)90044-7
  5. Lee HL, Hong DS, Sohn KC. Survey on allergic diseases in children. J Korean Med Assoc 1983;26:254-62
  6. Korean Academy of Pediatric Allergy and Respiratory Diseases. Prevalences of allergic diseases in korean children; a nationwide questionnaire survey: asthma. Committee of The Korean Academy of Pediatric Allergy and Respiratory Disease for Epidemiologic Study. Pediatr Allergy Respir Dis 2002;12:S49-53
  7. Lee SI, Shin MH, Lee HB, Lee JS, Son BK, Koh YY, et al. Prevalences of symptoms of asthma and other allergic disease in Korean children; A nationwide questionnaire survey. J Korean Med Sci 2001;16:155-64 https://doi.org/10.3346/jkms.2001.16.2.155
  8. Gergen PJ, Turkeltaub PC, Kovar MG. The prevalence of allergic skin tests reactivity to eight common aeroallergens in the U.S. population: results from the second National Health and Nutrition Examination Survey. J Allergy Clin Immunol 1987;80: 669-79 https://doi.org/10.1016/0091-6749(87)90286-7
  9. Kim MK, Oh SW. Change of causative inhalant allergens in respiratory allergic patients in Chungbuk district. J Asthma Allergy Clin Immunol 1999;19:696-702
  10. Lee JY. Tyrophagus putrescentiae; an important allergen in Daejon. J Asthma Allergy Clin Immunol 2002;22:703-10
  11. Ko YH, Park SY, Lee JH, Koo GJ, Koo SK, Lee SH, et al. A clinical statistics on the offending allergens of allergic rhinitis. Korean J Otolaryngol 1998;41:42-7
  12. Kim TB, Kim KM, Kim SH, Kang HR, Chang YS, Kim CW, et al. Sensitization rates for inhalant allergens in Korea; a multi-center study. J Asthma Allergy Clin Immunol 2003;23: 483-93
  13. Lee MH, Hong SC, Kim YK, Cho SH, Min KU, Kim YY. Prevalence of atopic rhinitis and causative allergens in children living in rural area of Cheju island. J Asthma Allergy Clin Immunol 2001;21:198-204
  14. Min KU, Kim YK, Jang YS, Jung JW, Bahn JW, Lee BJ, et al. Prevalence of allergic rhinitis and its causative allergens in people in rural area of Cheju island. J Asthma Allergy Clin Immunol 1999;19:42-9
  15. http://www.bugsworms.org
  16. Kim WK, Park JK, Lee SR, Son JW, Kim YK, Lee YK, et al. Recent increase of atopy prevalence in Seoul: 1990-1994. Korean J Asthma Allergy Clin Immunol 1995;15:304-10
  17. Gortmaker SL, Must A, Sobol AM, Peterson K, Colditz GA, Di WH. Television viewing as a cause of increasing obesity among children in the United States, 1986-1990. Arch Pediatr Adolesc Med 1996;150:356-62 https://doi.org/10.1001/archpedi.1996.02170290022003
  18. Park HS, Lee MK, Hong CS. Cat-induced respiratory allergy: Relationship between cat allergen and commercial extracts of house dust. Korean J Asthma Allergy Clin Immunol 1989;9:10-9
  19. Nahm DH, Park HS, Kang SS, Hong CS. Seasonal variation of skin reactivity and specific IgE antibody to house dust mites. Ann Allergy Asthma Immunol 1997;78:589-93 https://doi.org/10.1016/S1081-1206(10)63221-8
  20. Kaneko Y, Motohashi Y, Nakamura H, Endo T, Eboshida A. Increasing prevalence of Japanese cedar pollinosis: a metaregression analysis. Int Arch Allergy Immunol 2005;136:365-71 https://doi.org/10.1159/000084256
  21. Kim KH, Kim KT, Lee SG, Park HS, Lee YM, Nam DH, et al. Sensitization rates for inhalant allergens in patients with respiratory allergy in Busan. J Asthma Allergy Clin Immunol 2005;25:59-63
  22. Min KU, Kim YY, Jang SI. Study of Japanese cedar pollen in Cheju island. J Asthma Allergy Clin Immunol 1996;16:308-14
  23. Kim YY: Genetic and enviromental factors and intrinsic asthma, In Progress in allergy and clinical immunology. 4th ed. p 219-22, Hogrefe & Huber Publishers, 1997.
  24. Lee H, Jeon BH, Jang EH, Kim M, Chung YB, Lee J. Sensitization rates to inhalent allergens in atopic individuals in Jeju, Korea. J Med Life Sci 2009;6:119-25
  25. Shea KM, Truckner RT, Weber RW, Peden DB. Climate change and allergic disease. J Allergy Clin Immunol 2008;122:443-53 https://doi.org/10.1016/j.jaci.2008.06.032
  26. Korea Meteorological Administration data: http://www.kma.or.kr/ sfc/sfc_03_02.jsp
  27. Moriguchi H, Matsumoto M, Nishimoto Y, Kuwada K. The development of a pollen information system for the improvement of QOL. J Med Invest 2001;48:198-209
  28. Nishiike S, Orino S, Irifune N, Arimoto H, Sakaguchi Y, Takeda M, et al. Measurement of quality of life during different clinical phases of Japanese cedar pollinosis. Auris Nasus Larynx 2004; 31:135-9 https://doi.org/10.1016/j.anl.2004.01.002