Journal of asthma, allergy and clinical immunology (천식및알레르기)

The Korean Academy of Asthma, Allergy and Clinical Immunology (대한천식알레르기학회)
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The Effect of the Extracts of Taraxacum platycarpum (AF-343) in Atopic Dermatitis

아토피피부염 환자에서 민들레 추출물 함유제(AF-343)의 효과에 관한 연구

  • Kim, Ji-Hyun (Department of Pediatrics, Chung-Ang University College of Medicine) ;
  • Lee, Hye-In (Department of Dermatology, Chung-Ang University College of Medicine) ;
  • Park, Ju-Hee (Department of Dermatology, Chung-Ang University College of Medicine) ;
  • Lim, Yun-Young (Department of Dermatology, Chung-Ang University College of Medicine) ;
  • Kim, Beom-Joon (Department of Dermatology, Chung-Ang University College of Medicine) ;
  • Lim, In-Seok (Department of Pediatrics, Chung-Ang University College of Medicine) ;
  • Kim, Myeung-Nam (Department of Dermatology, Chung-Ang University College of Medicine) ;
  • Kim, Hyun-Suck (Sung Kyun Biotech Co., Ltd.) ;
  • Kim, Jong-Keun (Sung Kyun Biotech Co., Ltd.) ;
  • Han, Sung-Hoon (Sung Kyun Biotech Co., Ltd.) ;
  • Cho, Soo-Muk (Functional Food & Nutrition Division, Department of Agrofood Resources, NAAS, RDA) ;
  • Kim, Jae-Hyun (Functional Food & Nutrition Division, Department of Agrofood Resources, NAAS, RDA) ;
  • Park, Ki-Moon (Department of Food Science and Biotechnology, Sungkyunkwan University)
  • 김지현 (중앙대학교 의과대학 소아과학교실) ;
  • 이혜인 (중앙대학교 의과대학 피부과학교실) ;
  • 박주희 (중앙대학교 의과대학 피부과학교실) ;
  • 임윤영 (중앙대학교 의과대학 피부과학교실) ;
  • 김범준 (중앙대학교 의과대학 피부과학교실) ;
  • 임인석 (중앙대학교 의과대학 소아과학교실) ;
  • 김명남 (중앙대학교 의과대학 피부과학교실) ;
  • 김현석 (성균바이오텍) ;
  • 김종근 (성균바이오텍) ;
  • 한성훈 (성균바이오텍) ;
  • 조수묵 (국립농업과학원) ;
  • 김재현 (국립농업과학원) ;
  • 박기문 (성균관대학교 식품생명공학과)
  • Received : 2009.12.23
  • Accepted : 2010.02.27
  • Published : 2010.03.25
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Abstract

Background: Taraxacum platycarpum has been investigated for its antiallergic activity in bronchial asthma, but few studies have been conducted to evaluate its efficacy for the treatment of atopic dermatitis (AD). Objective: This study was designed to evaluate the efficacy of the extracts of Taraxacum platycarpum (AF-343) for the treatment of AD. Method: Seventy-five patients with AD were randomly assigned either to a low-dose, high-dose or control groups. AF-343 and placebo were ingested for 8 weeks. The SCORing Atopic Dermatitis (SCORAD) scores, skin hydration, transepidermal water loss (TEWL), eosinophil, total IgE, eosinophil catinonic protein and cytokines were measured before and at the end of treatment. Result: A significant reduction in the SCORAD scores at the end of treatment were observed in the control, low-dose and high-dose groups when compared with the initial scores (P=0.028, P<0.001 and P<0.001, respectively). High-dose treatment increased the skin hydration (P=0.013), but no significant change was observed in the low-dose and control groups (P=0.056 and P=0.624, respectively). The low-dose and high-dose treatment groups showed a significant reduction of TEWL from baseline (P=0.002 and P=0.031, respectively). High-dose treatment induced an increase in eotaxin and a decrease in IL-5 (P=0.021 and P=0.028, respectively). Conclusion: These results show that AF-343 treatment can improve the severity and skin hydration in patients with mild AD.

Keywords

Acknowledgement

Supported by : 농촌진흥청

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