Genes and Genomics

The Genetics Society of Korea (한국유전학회)
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Aged wild-type littermates and $APP_{swe}$+PS1/${\Delta}$E9 mice present similar deficits in associative learning and spatial memory independent of amyloid load

  • Park, Soo-Won (National Creative Research Initiative Center for Memory, Departments of Biological Sciences, College of Natural Sciences, Seoul National University) ;
  • Ko, Hyoung-Gon (National Creative Research Initiative Center for Memory, Departments of Biological Sciences, College of Natural Sciences, Seoul National University) ;
  • Lee, Nuri-Bal-Hae (National Creative Research Initiative Center for Memory, Departments of Biological Sciences, College of Natural Sciences, Seoul National University) ;
  • Lee, Hye-Ryeon (National Creative Research Initiative Center for Memory, Departments of Biological Sciences, College of Natural Sciences, Seoul National University) ;
  • Rim, Young-Soo (National Creative Research Initiative Center for Memory, Departments of Biological Sciences, College of Natural Sciences, Seoul National University) ;
  • Kim, Hyoung (National Creative Research Initiative Center for Memory, Departments of Biological Sciences, College of Natural Sciences, Seoul National University) ;
  • Lee, Kyung-Min (Department of Anatomy, School of Medicine, Kyungpook National University) ;
  • Kaang, Bong-Kiun (National Creative Research Initiative Center for Memory, Departments of Biological Sciences, College of Natural Sciences, Seoul National University)
  • Received : 2009.10.13
  • Accepted : 2009.12.11
  • Published : 2010.02.28
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Abstract

APPswe+PS1/${\Delta}$E9 transgenic (Tg) mice with A${\beta}$ plaque formation in neocortex and hippocampus were evaluated in tests measuring exploratory activity, anxiety, and memory ability using open field test (OFT), Y-maze, contextual fear conditioning (CFC), and Morris water maze (MWM). Wild type (WT) and Tg mice over eight months old showed same locomotion activity and anxiety level in novel stimulation, open field, and Y-maze contexts. In other experiments that measured associative memory and spatial memory in Tg mice and their littermates, the subjects also presented similar deficiencies in memory acquisition. These two aged groups showed abnormal freezing level variance especially in CFC test. In comparison to that in non-transgenic 8-week-old mice group, the acquisition of spatial memory in MWM task was impaired in aged WT and bigenic Tg mice. Taken together, aged wild-type littermates and Tg mice present similar deficits in associative learning and spatial memory independent of amyloid plaques.

Keywords

References

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