Journal of Pathology and Translational Medicine (대한병리학회지)

The Korean Society of Pathologists (대한병리학회)
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Human Papillomavirus Prevalence in Gangwon Province Using Reverse Blot Hybridization Assay

Reverse Blot Hybridization Assay를 이용한 강원지역에서의 인유두종바이러스 유전형의 분포도 조사

  • Lee, Dong-Sup (Department of Biomedical Laboratory Science, College of Health Science, Yonsei University) ;
  • Kim, Sung-Hyun (Department of Biomedical Laboratory Science, College of Health Science, Yonsei University) ;
  • Park, Sang-Jung (Department of Biomedical Laboratory Science, College of Health Science, Yonsei University) ;
  • Jin, Hyun-Woo (Department of Biomedical Laboratory Science, College of Health Science, Yonsei University) ;
  • Kim, Tae-Ue (Department of Biomedical Laboratory Science, College of Health Science, Yonsei University) ;
  • Park, Kwang-Hwa (Department of Pathology, Yonsei University Wonju College of Medicine) ;
  • Lee, Hye-Young (Department of Biomedical Laboratory Science, College of Health Science, Yonsei University)
  • 이동섭 (연세대학교 보건과학대학 임상병리학과) ;
  • 김성현 (연세대학교 보건과학대학 임상병리학과) ;
  • 박상정 (연세대학교 보건과학대학 임상병리학과) ;
  • 진현우 (연세대학교 보건과학대학 임상병리학과) ;
  • 김태우 (연세대학교 보건과학대학 임상병리학과) ;
  • 박광화 (연세대학교 원주의과대학 병리학교실) ;
  • 이혜영 (연세대학교 보건과학대학 임상병리학과)
  • Published : 2011.08.25
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Abstract

Background: Human papillomavirus (HPV) plays an important role in the development of cervical carcinoma. Although there is a general agreement that high levels of HPV are related to cervical cancer, the prevalence and distribution of HPV genotypes seems to vary by geographical region. This study was designed to investigate the prevalence of HPV genotypes in Gangwon Province, Korea. Methods: In total, 342 samples were examined by Pap smear and $HPV-ID^{(R)}$ reverse blot hybridization assay (REBA) (M&D, Wonju, Korea). Results: Overall HPV positivity was 80.9% and 64.4% in women with abnormal and normal cytology by REBA, respectively. The five most common HPV types were: HPV 16, 53, 58, 56, and 33 in samples with abnormal cytology, and HPV 16, 53, 58, 70, and 18 in samples with normal cytology. Conclusions: The REBA can provide useful data regarding prevalence of HPV genotypes. Gangwon Province showed high prevalence of HPV infection in women. The most common HPV type in Gangwon Province was HPV16, and HPV 53, 58, 56, 70 were frequently present.

Keywords

References

  1. de Sanjose S, Diaz M, Castellsague X, et al. Worldwide prevalence and genotype distribution of cervical human papillomavirus DNA in women with normal cytology: a meta-analysis. Lancet Infect Dis 2007; 7: 453-9. https://doi.org/10.1016/S1473-3099(07)70158-5
  2. Bosch FX, Manos MM, Munoz N, et al. Prevalence of human papillomavirus in cervical cancer: a worldwide perspective. International biological study on cervical cancer (IBSCC) Study Group. J Natl Cancer Inst 1995; 87: 796-802. https://doi.org/10.1093/jnci/87.11.796
  3. Yugawa T, Kiyono T. Molecular mechanisms of cervical carcinogenesis by high-risk human papillomaviruses: novel functions of E6 and E7 oncoproteins. Rev Med Virol 2009; 19: 97-113. https://doi.org/10.1002/rmv.605
  4. Munoz N, Bosch FX, de Sanjose S, et al. Epidemiologic classification of human papillomavirus types associated with cervical cancer. N Engl J Med 2003; 348: 518-27. https://doi.org/10.1056/NEJMoa021641
  5. An HJ, Cho NH, Lee SY, et al. Correlation of cervical carcinoma and precancerous lesions with human papillomavirus (HPV) genotypes detected with the HPV DNA chip microarray method. Cancer 2003; 97: 1672-80. https://doi.org/10.1002/cncr.11235
  6. Hong SR, Kim IS, Kim DW, et al. Prevalence and genotype distribution of cervical human papillomavirus DNA in Korean women: a multicenter study. Korean J Pathol 2009; 43: 342-50. https://doi.org/10.4132/KoreanJPathol.2009.43.4.342
  7. Park TC, Kim CJ, Lee KH, et al. HPV genotyping in Korean women with cervical neoplasia. Korean J Gynecol Oncol Colposc 2003; 14: 40-8.
  8. Hwang TS, Jeong JK, Park M, Han HS, Choi HK, Park TS. Detection and typing of HPV genotypes in various cervical lesions by HPV oligonucleotide microarray. Gynecol Oncol 2003; 90: 51-6. https://doi.org/10.1016/S0090-8258(03)00201-4
  9. Kim YS, Lee HJ, Lee GG, et al. Detection of human papillomavirus type 16 and 18 in cervical specimens by nested polymerase chain reaction. Korean J Clin Pathol 2001; 21: 210-4.
  10. Vizcaino AP, Moreno V, Bosch FX, Munoz N, Barros-Dios XM, Parkin DM. International trends in the incidence of cervical cancer: I. Adenocarcinoma and adenosquamous cell carcinomas. Int J Cancer 1998; 75: 536-45. https://doi.org/10.1002/(SICI)1097-0215(19980209)75:4<536::AID-IJC8>3.0.CO;2-U
  11. Kwon HS, Kim YT, Kim JW, Kim SH. Comparison of oligonucleotide microarray-based test with hybrid capture-based test for detecting carcinogenic HPV in patients with CIN and invasive cervical cancer. Korean J Gynecol Oncol Colposc 2002; 13: 327-35.
  12. zur Hausen H. Papillomaviruses causing cancer: evasion from host-cell control in early events in carcinogenesis. J Natl Cancer Inst 2000; 92: 690-8. https://doi.org/10.1093/jnci/92.9.690
  13. Agarossi A, Ferrazzi E, Parazzini F, Perno CF, Ghisoni L. Prevalence and type distribution of high-risk human papillomavirus infection in women undergoing voluntary cervical cancer screening in Italy. J Med Virol 2009; 81: 529-35. https://doi.org/10.1002/jmv.21347
  14. Wells SI, Aronow BJ, Wise TM, Williams SS, Couget JA, Howley PM. Transcriptome signature of irreversible senescence in human papillomavirus-positive cervical cancer cells. Proc Natl Acad Sci U S A 2003; 100: 7093-8. https://doi.org/10.1073/pnas.1232309100
  15. Hutchinson DJ, Klein KC. Human papillomavirus disease and vaccines. Am J Health Syst Pharm 2008; 65: 2105-12. https://doi.org/10.2146/ajhp070627
  16. Berchtold A, Michaud PA, Nardelli-Haefliger D, Suris JC. Vaccination against human papillomavirus in Switzerland: simulation of the impact on infection rates. Int J Public Health 2010; 55: 25-34. https://doi.org/10.1007/s00038-009-0081-3
  17. Cento V, Ciccozzi M, Ronga L, Perno CF, Ciotti M. Genetic diversity of human papillomavirus type 16 E6, E7, and L1 genes in Italian women with different grades of cervical lesions. J Med Virol 2009; 81: 1627-34. https://doi.org/10.1002/jmv.21552
  18. Rambout L, Hopkins L, Hutton B, Fergusson D. Prophylactic vaccination against human papillomavirus infection and disease in women: a systematic review of randomized controlled trials. CMAJ 2007; 177: 469-79. https://doi.org/10.1503/cmaj.070948
  19. Lee HS, Kim KM, Kim SM, et al. Human papillomavirus genotyping using HPV DNA chip analysis in Korean women. Int J Gynecol Cancer 2007; 17: 497-501. https://doi.org/10.1111/j.1525-1438.2007.00871.x
  20. Clifford GM, Smith JS, Plummer M, Munoz N, Franceschi S. Human papillomavirus types in invasive cervical cancer worldwide: a meta-analysis. Br J Cancer 2003; 88: 63-73. https://doi.org/10.1038/sj.bjc.6600688
  21. Bae JH, Lee SJ, Kim CJ, et al. Human papillomavirus (HPV) type distribution in Korean women: a meta-analysis. J Microbiol Biotechnol 2008; 18: 788-94.
  22. Berek JS. Novak's gynecology. 13th ed. Philadelphia: Lippincott Williams and Wilkins, 2002.
  23. Ho GY, Burk RD, Klein S, et al. Persistent genital human papillomavirus infection as a risk factor for persistent cervical dysplasia. J Natl Cancer Inst 1995; 87: 1365-71. https://doi.org/10.1093/jnci/87.18.1365