Incidences of Cancers in Diabetic and Non-diabetic Hospitalized Adult Patients in Taiwan

Chiou, Wen-Ko;Huang, Bie-Yu;Chou, Wei-Ying;Weng, Hsiao-Fen;Lin, Jen-Der

  • Published : 20110600

Abstract

Background: The study was to investigate the relationship between diabetes mellitus ( DM), specific cancers, age, and gender. Methods: This was a retrospective study that examined the frequency of different forms of cancer among male and female patients with or without DM admitted to a single hospital in Taiwan between January 2009 and June 2010. Results: Of 101,002 study patients admitted to the hospital, 15,901 (15.74%) were diagnosed with DM and 16,748 (16.58%) with a malignancy. The frequency of DM differed between males and females (17.5% vs 14.2%; P < 0.001), and males had a higher cancer incidence than females (20.2% vs 13.5%; P < 0.001). Patients with DM had a greater frequency of cancer diagnosis than non-DM patients (18.1% vs 16.3%, respectively), with pancreatic, liver, uterine, urinary tract, lung, and secondary cancers being more frequent in DM compared with non-DM patients. In contrast, the proportion of patients with thyroid, esophagus, breast, NPC, and other cancers was lower in DM versus non-DM patients. Conclusions: This study found that DM was associated with the incidence of specific cancers and that males had a higher frequency of cancer than females. The association of DM and cancer depended upon cancer type, gender, and age.

Keywords

References

  1. American Diabetes Association (2010). Diagnosis and classification of diabetes mellitus. Diabetes Care, 33 (Suppl. 1), S62-9. https://doi.org/10.2337/dc10-S062
  2. Atchison EA, Gridley G, Carreon JD, et al (2011). Risk of cancer in a large cohort of U.S. veterans with diabetes. Int J Cancer, 128, 635-43. https://doi.org/10.1002/ijc.25362
  3. Ben Q, Cai Q, Li Z, et al (2011). The relationship between new-onset diabetes mellitus and pancreatic cancer risk: a case-control study. Eur J Cancer, 47, 248-54. https://doi.org/10.1016/j.ejca.2010.07.010
  4. Bianchini F, Kaaks R, Vainio H (2002). Overweight, obesity, and cancer risk. Lancet Oncol, 3, 565-74. https://doi.org/10.1016/S1470-2045(02)00849-5
  5. Calle EE, Thun MJ (2004). Obesity and cancer. Oncogene, 23, 6365-78. https://doi.org/10.1038/sj.onc.1207751
  6. Campbell PT, Deka A, Jacobs EJ, et al (2010). Prospective study reveals associations between colorectal cancer and type 2 diabetes mellitus or insulin use in men. Gastroenerology, 139, 1138-46. https://doi.org/10.1053/j.gastro.2010.06.072
  7. Chari ST, Leibson CL, Rabe KG, et al (2005). Probability of pancreatic cancer following diabetes: a population-based study. Gastroenterology, 129, 504-11. https://doi.org/10.1016/j.gastro.2005.05.007
  8. Chu CK, Mazo AE, Goodman M, Egnatashvili V, et al (2010). Preoperative diabetes mellitus and long-term survival after resection of pancreatic adenocarcinoma. Ann Surg Oncol, 17, 502-13. https://doi.org/10.1245/s10434-009-0789-6
  9. Conover CA, Lee PD, Kanaley JA, et al (1992). Insulin regulation of insulin-like growth factor binding protein-1 in obese and nonobese humans. J Clin Endocrinol Metab, 74, 1355-60. https://doi.org/10.1210/jc.74.6.1355
  10. El-Serag HB, Richardson PA, Everhart JE (2001). The role of diabetes in hepatocellular carcinoma: a case-control study among United States Veterans. Am J Gastroenterol, 96, 2462-7. https://doi.org/10.1111/j.1572-0241.2001.04054.x
  11. Hung CH, Wang JH, Hu TH, et al (2010). Insulin resistance is associated with hepatocellular carcinoma in chronic hepatitis C infection. World J Gastroenterol, 16, 2265-71. https://doi.org/10.3748/wjg.v16.i18.2265
  12. Inoue M, Iwasaki M, Otani T, et al (2006). Diabetes mellitus and the risk of cancer: results from a large-scale population-based cohort study in Japan. Arch Intern Med, 166, 1871-7. https://doi.org/10.1001/archinte.166.17.1871
  13. Jamal MM, Yoon EJ, Vega KJ, et al (2009). Diabetes mellitus as a risk factor for gastrointestinal cancer among American veterans. World J Gastroenterol, 15, 5274-8. https://doi.org/10.3748/wjg.15.5274
  14. Jee SH, Yun JE, Park EJ, et al (2008). Body mass index and cancer risk in Korean men and women. Int J Cancer, 123, 1892-6. https://doi.org/10.1002/ijc.23719
  15. Johnson JA, Pollak M (2010). Insulin, glucose and the increased risk of cancer in patients with type 2 diabetes. Diabetologia, 53, 2086-8. https://doi.org/10.1007/s00125-010-1855-0
  16. Khan M, Mori M, Fujino Y, et al (2006). Japan Collaborative Cohort Study Group. Site-specific cancer risk due to diabetes mellitus history: evidence from the Japan Collaborative Cohort (JACC) Study. Asian Pac J Cancer Prev, 7, 253-9.
  17. Khandwala HM, McCutcheon IE, Flyvbjerg A, et al (2000). The effects of insulin-like growth factors on tumorigenesis and neoplastic growth. Endocr Rev, 21, 215-44. https://doi.org/10.1210/er.21.3.215
  18. Kuriyama S, Tsubono Y, Hozawa A, et al (2005). Obesity and risk of cancer in Japan. Int J Cancer, 113, 148-57. https://doi.org/10.1002/ijc.20529
  19. Larsson SC, Orsini N, Wolk A (2005). Diabetes mellitus and risk of colorectal cancer: a meta-analysis. J Natl Cancer Inst, 97, 1679-87. https://doi.org/10.1093/jnci/dji375
  20. Lee MS, Hsu CC, Wahlqvist ML, et al (2011). Type 2 diabetes increases and metformin reduces total, colorectal, liver and pancreatic cancer incidences in Taiwanese: a representative population prospective cohort study of 800,000 individuals. BMC Cancer, 11, 20. https://doi.org/10.1186/1471-2407-11-20
  21. Levesque R, SPSS (2007) Programming and Data Management for SPSS 16.0: A Guide for SPSS and SAS Users, SPSS Inc., Chicago Ill.
  22. Limburg PJ, Anderson KE, Johnson TW, et al (2005). Diabetes mellitus and subsite-specific colorectal cancer risks in the Iowa Women's Health Study. Cancer Epidemiol Biomarkers Prev, 14, 133-7.
  23. Michels KB, Terry KL, Willett WC (2006). Longitudinal study on the role of body size in premenopausal breast cancer. Arch Intern Med, 166, 2395-402. https://doi.org/10.1001/archinte.166.21.2395
  24. Mijovic T, How J, Pakdaman M, et al (2009). Body mass index in the evaluation of thyroid cancer risk. Thyroid, 19, 467-72. https://doi.org/10.1089/thy.2008.0386
  25. Paes JE, Hua K, Nagy R, et al (2010). The relationship between body mass index and thyroid cancer pathology features and outcomes: a clinicopathological cohort study. J Clin Endocrinol Metab, 95, 4244-50. https://doi.org/10.1210/jc.2010-0440
  26. Pannala R, Leirness JB, Bamlet WR, et al (2008). Prevalence and clinical profile of pancreatic cancer-associated diabetes mellitus. Gastroenterology, 134, 981-7. https://doi.org/10.1053/j.gastro.2008.01.039
  27. Polesel J, Zucchetto A, Montella M, et al (2009). The impact of obesity and diabetes mellitus on the risk of hepatocellular carcinoma. Ann Oncol, 20, 353-7.
  28. Tung HD, Wang JH, Tseng PL, et al (2010). Neither diabetes mellitus nor overweight is a risk factor for hepatocellular carcinoma in a dual HBV and HCV endemic area: community cross-sectional and case-control studies. Am J Gastroenterol, 105, 624-31. https://doi.org/10.1038/ajg.2009.711
  29. Vigneri P, Frasca F, Sciacca L, et al (2009). Diabetes and cancer. Endocr Relat Cancer, 16, 1103-23. https://doi.org/10.1677/ERC-09-0087
  30. Xue F, Michels KB (2007). Diabetes, metabolic syndrome, and breast cancer: a review of the current evidence. Am J Clin Nutr, 86, s823-35. https://doi.org/10.1093/ajcn/86.3.823S