Journal of stroke

Korean Stroke Society (대한뇌졸중학회)
권호 표지
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Rat Models for Ischemic Stroke

허혈성 뇌졸중의 동물 모델

  • Kim, Hyun-Young (Department of Neurology, College of Medicine, Hanyang University) ;
  • Koh, Seong-Ho (Department of Neurology, College of Medicine, Hanyang University) ;
  • Kim, Seung-Hyun (Department of Neurology, College of Medicine, Hanyang University)
  • 김현영 (한양대학교 의과대학 신경과학교실) ;
  • 고성호 (한양대학교 의과대학 신경과학교실) ;
  • 김승현 (한양대학교 의과대학 신경과학교실)
  • Published : 2011.12.31
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Abstract

Highly reproducible and consistent ischemic stroke models are critical for obtaining more confi dent data. To date, the infarct variation of several ischemic rat models is considerable. Therefore, many factors related to outcome variation and infarct growth must be controlled. Among various infarct models of rodents, intraluminal fi lament model is common by virtue of its consistency of the success rate and the outcomes. Recently more long-term evaluation of functional and imaging outcomes is considered in terms of clinical practice. Concise and subsequent outcome assessment could result in the improvement of translational stroke research. We recommend that the researchers should remember the guidelines addressed by the Stroke Therapy Academic Industry Roundtable (STAIR) and the Good Laboratory Practice (GLP).

Keywords

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